A Humanized and Defucosylated Antibody against Podoplanin (humLpMab-23-f) Exerts Antitumor Activities in Human Lung Cancer and Glioblastoma Xenograft Models

SIMPLE SUMMARY: Podoplanin (PDPN), also known as T1α/Aggrus/gp36, is a type I transmembrane sialo-glycoprotein that plays essential roles in cancer progression and metastasis. PDPN-expressing cancers show aggressive phenotypes, including increased stemness, invasiveness, and epithelial-to-mesenchyma...

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Detalles Bibliográficos
Autores principales: Suzuki, Hiroyuki, Ohishi, Tomokazu, Kaneko, Mika K., Kato, Yukinari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605305/
https://www.ncbi.nlm.nih.gov/pubmed/37894446
http://dx.doi.org/10.3390/cancers15205080

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605305/
https://www.ncbi.nlm.nih.gov/pubmed/37894446
http://dx.doi.org/10.3390/cancers15205080

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