Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential

Galectin-3 (Gal-3) plays a multifaceted role in the development, progression, and prognosis of pancreatic ductal adenocarcinoma (PDAC). This review offers a comprehensive examination of its expression in PDAC, its interaction with various immune cells, signaling pathways, effects on apoptosis, and t...

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Autores principales: Dimitrijevic Stojanovic, Milica, Stojanovic, Bojan, Radosavljevic, Ivan, Kovacevic, Vojin, Jovanovic, Ivan, Stojanovic, Bojana S., Prodanovic, Nikola, Stankovic, Vesna, Jocic, Miodrag, Jovanovic, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605315/
https://www.ncbi.nlm.nih.gov/pubmed/37892182
http://dx.doi.org/10.3390/biom13101500
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author Dimitrijevic Stojanovic, Milica
Stojanovic, Bojan
Radosavljevic, Ivan
Kovacevic, Vojin
Jovanovic, Ivan
Stojanovic, Bojana S.
Prodanovic, Nikola
Stankovic, Vesna
Jocic, Miodrag
Jovanovic, Marina
author_facet Dimitrijevic Stojanovic, Milica
Stojanovic, Bojan
Radosavljevic, Ivan
Kovacevic, Vojin
Jovanovic, Ivan
Stojanovic, Bojana S.
Prodanovic, Nikola
Stankovic, Vesna
Jocic, Miodrag
Jovanovic, Marina
author_sort Dimitrijevic Stojanovic, Milica
collection PubMed
description Galectin-3 (Gal-3) plays a multifaceted role in the development, progression, and prognosis of pancreatic ductal adenocarcinoma (PDAC). This review offers a comprehensive examination of its expression in PDAC, its interaction with various immune cells, signaling pathways, effects on apoptosis, and therapeutic resistance. Additionally, the prognostic significance of serum levels of Gal-3 is discussed, providing insights into its potential utilization as a biomarker. Critical analysis is also extended to the inhibitors of Gal-3 and their potential therapeutic applications in PDAC, offering new avenues for targeted treatments. The intricate nature of Gal-3’s role in PDAC reveals a complex landscape that demands a nuanced understanding for potential therapeutic interventions and monitoring.
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spelling pubmed-106053152023-10-28 Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential Dimitrijevic Stojanovic, Milica Stojanovic, Bojan Radosavljevic, Ivan Kovacevic, Vojin Jovanovic, Ivan Stojanovic, Bojana S. Prodanovic, Nikola Stankovic, Vesna Jocic, Miodrag Jovanovic, Marina Biomolecules Review Galectin-3 (Gal-3) plays a multifaceted role in the development, progression, and prognosis of pancreatic ductal adenocarcinoma (PDAC). This review offers a comprehensive examination of its expression in PDAC, its interaction with various immune cells, signaling pathways, effects on apoptosis, and therapeutic resistance. Additionally, the prognostic significance of serum levels of Gal-3 is discussed, providing insights into its potential utilization as a biomarker. Critical analysis is also extended to the inhibitors of Gal-3 and their potential therapeutic applications in PDAC, offering new avenues for targeted treatments. The intricate nature of Gal-3’s role in PDAC reveals a complex landscape that demands a nuanced understanding for potential therapeutic interventions and monitoring. MDPI 2023-10-10 /pmc/articles/PMC10605315/ /pubmed/37892182 http://dx.doi.org/10.3390/biom13101500 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dimitrijevic Stojanovic, Milica
Stojanovic, Bojan
Radosavljevic, Ivan
Kovacevic, Vojin
Jovanovic, Ivan
Stojanovic, Bojana S.
Prodanovic, Nikola
Stankovic, Vesna
Jocic, Miodrag
Jovanovic, Marina
Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential
title Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential
title_full Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential
title_fullStr Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential
title_full_unstemmed Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential
title_short Galectin-3’s Complex Interactions in Pancreatic Ductal Adenocarcinoma: From Cellular Signaling to Therapeutic Potential
title_sort galectin-3’s complex interactions in pancreatic ductal adenocarcinoma: from cellular signaling to therapeutic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605315/
https://www.ncbi.nlm.nih.gov/pubmed/37892182
http://dx.doi.org/10.3390/biom13101500
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