Cargando…

PACAP–Sirtuin3 alleviates cognitive impairment through autophagy in Alzheimer’s disease

BACKGROUND: Autophagy is vital in the pathogenesis of neurodegeneration. Thus far, no studies have specifically investigated the relationship between pituitary adenylate cyclase-activating polypeptide (PACAP) and autophagy, particularly in the context of Alzheimer’s disease (AD). This study used in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Qing, Wang, Yue, Li, Shiping, Shi, Jiong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605376/ https://www.ncbi.nlm.nih.gov/pubmed/37891608 http://dx.doi.org/10.1186/s13195-023-01334-2

Ejemplares similares

Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway
por: Yin, Junxiang, et al.
Publicado: (2019)

The neuropeptide PACAP alleviates T. gondii infection-induced neuroinflammation and neuronal impairment
por: Figueiredo, Caio Andreeta, et al.
Publicado: (2022)

Sirtuin 3 promotes microglia migration by upregulating CX3CR1
por: Cao, Runjing, et al.
Publicado: (2019)

Sirtuin 3 attenuates amyloid-β induced neuronal hypometabolism
por: Yin, Junxiang, et al.
Publicado: (2018)

Ketones improves Apolipoprotein E4-related memory deficiency via sirtuin 3
por: Yin, Junxiang, et al.
Publicado: (2019)

Suppression of sirtuin 1 alleviates airway inflammation through mTOR-mediated autophagy
por: Wu, Yuanyuan, et al.
Publicado: (2020)

The effects of blood pressure on post stroke cognitive impairment: BP and PSCI
por: Wang, Yue, et al.
Publicado: (2021)

The role of sirtuins in Alzheimer's disease
por: Lalla, Rakhee, et al.
Publicado: (2013)

PACAP Modulates the Autophagy Process in an In Vitro Model of Amyotrophic Lateral Sclerosis
por: D’Amico, Agata Grazia, et al.
Publicado: (2020)

Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer’s Disease-Like Pathology and Cognitive Impairments
por: Mahaman, Yacoubou Abdoul Razak, et al.
Publicado: (2018)

Expression Patterns of PACAP and PAC1R Genes and Anorexigenic Action of PACAP1 and PACAP2 in Zebrafish
por: Nakamachi, Tomoya, et al.
Publicado: (2019)

Intermedin Alleviates Vascular Calcification in CKD through Sirtuin 3-Mediated Inhibition of Mitochondrial Oxidative Stress
por: Liu, Shi-Meng, et al.
Publicado: (2022)

Necroptosis Inhibition by Hydrogen Sulfide Alleviated Hypoxia-Induced Cardiac Fibroblasts Proliferation via Sirtuin 3
por: Zhang, Yue, et al.
Publicado: (2021)

MEX3C induces cognitive impairment in mice through autophagy inhibition
por: Wang, Kai, et al.
Publicado: (2023)

Inhibition of aerobic glycolysis alleviates sepsis-induced acute kidney injury by promoting lactate/Sirtuin 3/AMPK-regulated autophagy
por: Tan, Chuyi, et al.
Publicado: (2021)

Alterations in mitochondrial dynamics with age‐related Sirtuin1/Sirtuin3 deficiency impair cardiomyocyte contractility
por: Zhang, Jingwen, et al.
Publicado: (2021)

The Current State of Research on Sirtuin-Mediated Autophagy in Cardiovascular Diseases
por: Wang, Yuqin, et al.
Publicado: (2023)

Methylprednisolone alleviates cognitive functions through the regulation of neuroinflammation in Alzheimer’s disease
por: Sun, Yuan, et al.
Publicado: (2023)

Sirtuin 3 Alleviates Diabetic Cardiomyopathy by Regulating TIGAR and Cardiomyocyte Metabolism
por: Li, Lanfang, et al.
Publicado: (2021)

RTN4B‐mediated suppression of Sirtuin 2 activity ameliorates β‐amyloid pathology and cognitive impairment in Alzheimer's disease mouse model
por: Wang, Yan, et al.
Publicado: (2020)

MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models
por: Du, Yehong, et al.
Publicado: (2019)

Sirtuins promote brain homeostasis, preventing Alzheimer’s disease through targeting neuroinflammation
por: Watroba, Mateusz, et al.
Publicado: (2022)

Caspase-1 inhibition alleviates cognitive impairment and neuropathology in an Alzheimer’s disease mouse model
por: Flores, Joseph, et al.
Publicado: (2018)

Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR
por: Blagosklonny, M V
Publicado: (2010)

Seizing the Alzheimer’s Brain: A Role for Sirtuin 3 in Hyperexcitability
por: Aroor, Alisha, et al.
Publicado: (2020)

PACAP is Implicated in the Stress Axes
por: Hashimoto, Hitoshi, et al.
Publicado: (2011)

Protective effects of PACAP in ischemia
por: Reglodi, Dora, et al.
Publicado: (2018)

Multimodal Role of PACAP in Glioblastoma
por: D’Amico, Agata Grazia, et al.
Publicado: (2021)

Effect of PACAP on Heat Exposure
por: Suzuki, Keisuke, et al.
Publicado: (2023)

Sirtuin 2 Alleviates Chronic Neuropathic Pain by Suppressing Ferroptosis in Rats
por: Zhang, Xiaojiao, et al.
Publicado: (2022)

Targeting VIP and PACAP Receptor Signaling: New Insights into Designing Drugs for the PACAP Subfamily of Receptors
por: Lu, Jessica, et al.
Publicado: (2022)

Autophagy and mitophagy biomarkers are reduced in sera of patients with Alzheimer’s disease and mild cognitive impairment
por: Castellazzi, Massimiliano, et al.
Publicado: (2019)

PACAP-38 and PACAP(6–38) Degranulate Rat Meningeal Mast Cells via the Orphan MrgB(3)-Receptor
por: Pedersen, Sara Hougaard, et al.
Publicado: (2019)

Reading activities compensate for low education-related cognitive deficits
por: Wang, Yue, et al.
Publicado: (2022)

Sleep, Sirtuin 1 and Alzheimer’s disease: A review
por: Mehramiz, Mehrane, et al.
Publicado: (2022)

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
por: Morselli, E, et al.
Publicado: (2010)

Dynamic changes in CGRP, PACAP, and PACAP receptors in the trigeminovascular system of a novel repetitive electrical stimulation rat model: Relevant to migraine
por: Zhang, Qing, et al.
Publicado: (2019)

Characteristics of Agraphia in Chinese Patients with Alzheimer's Disease and Amnestic Mild Cognitive Impairment
por: Zhou, Jiong, et al.
Publicado: (2016)

Role of endocrine PACAP in age-related diseases
por: Toth, Denes, et al.
Publicado: (2023)

Enhancement of oligodendrocyte autophagy alleviates white matter injury and cognitive impairment induced by chronic cerebral hypoperfusion in rats
por: Wang, Huiyang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_teo6uvlaf4gvpb51csppp7f4bo