The T Cell Immunoscore as a Reference for Biomarker Development Utilizing Real-World Data from Patients with Advanced Malignancies Treated with Immune Checkpoint Inhibitors †

SIMPLE SUMMARY: This study utilized real-world data from patients with advanced malignancies who underwent immune checkpoint inhibitor (ICI) treatment. We used transcriptomic data to derive an immunoscore based on CD3+ and CD8+ T cell densities using CIBERSORTx and the LM22 gene signature matrix. Th...

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Detalles Bibliográficos
Autores principales: Eljilany, Islam, Saghand, Payman Ghasemi, Chen, James, Ratan, Aakrosh, McCarter, Martin, Carpten, John, Colman, Howard, Ikeguchi, Alexandra P., Puzanov, Igor, Arnold, Susanne, Churchman, Michelle, Hwu, Patrick, Conejo-Garcia, Jose, Dalton, William S., Weiner, George J., El Naqa, Issam M., Tarhini, Ahmad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605389/
https://www.ncbi.nlm.nih.gov/pubmed/37894280
http://dx.doi.org/10.3390/cancers15204913

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