Intranasal Delivery of Oncolytic Adenovirus XVir-N-31 via Optimized Shuttle Cells Significantly Extends Survival of Glioblastoma-Bearing Mice

SIMPLE SUMMARY: Glioblastomas (GBMs) are difficult-to-treat, deadly brain tumors and may infiltrate the whole brain. Cancer-killing (oncolytic) viruses have been used to treat GBMs. However, oncolytic virotherapy needs surgery, as the viruses have to be injected directly into the tumor. Human hepati...

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Detalles Bibliográficos
Autores principales: El-Ayoubi, Ali, Klawitter, Moritz, Rüttinger, Jakob, Wellhäusser, Giulia, Holm, Per Sonne, Danielyan, Lusine, Naumann, Ulrike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605419/
https://www.ncbi.nlm.nih.gov/pubmed/37894279
http://dx.doi.org/10.3390/cancers15204912

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