The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma

Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here...

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Autores principales: Irshad, Khushboo, Huang, Yu-Kai, Rodriguez, Paul, Lo, Jung, Aghoghovwia, Benjamin E., Pan, Yuan, Chang, Kun-Che
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605541/
https://www.ncbi.nlm.nih.gov/pubmed/37891793
http://dx.doi.org/10.3390/brainsci13101424
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author Irshad, Khushboo
Huang, Yu-Kai
Rodriguez, Paul
Lo, Jung
Aghoghovwia, Benjamin E.
Pan, Yuan
Chang, Kun-Che
author_facet Irshad, Khushboo
Huang, Yu-Kai
Rodriguez, Paul
Lo, Jung
Aghoghovwia, Benjamin E.
Pan, Yuan
Chang, Kun-Che
author_sort Irshad, Khushboo
collection PubMed
description Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration.
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spelling pubmed-106055412023-10-28 The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma Irshad, Khushboo Huang, Yu-Kai Rodriguez, Paul Lo, Jung Aghoghovwia, Benjamin E. Pan, Yuan Chang, Kun-Che Brain Sci Review Optic pathway glioma (OPG) is one of the causes of pediatric visual impairment. Unfortunately, there is as yet no cure for such a disease. Understanding the underlying mechanisms and the potential therapeutic strategies may help to delay the progression of OPG and rescue the visual morbidities. Here, we provide an overview of preclinical OPG studies and the regulatory pathways controlling OPG pathophysiology. We next discuss the role of microenvironmental cells (neurons, T cells, and tumor-associated microglia and macrophages) in OPG development. Last, we provide insight into potential therapeutic strategies for treating OPG and promoting axon regeneration. MDPI 2023-10-07 /pmc/articles/PMC10605541/ /pubmed/37891793 http://dx.doi.org/10.3390/brainsci13101424 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Irshad, Khushboo
Huang, Yu-Kai
Rodriguez, Paul
Lo, Jung
Aghoghovwia, Benjamin E.
Pan, Yuan
Chang, Kun-Che
The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma
title The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma
title_full The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma
title_fullStr The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma
title_full_unstemmed The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma
title_short The Neuroimmune Regulation and Potential Therapeutic Strategies of Optic Pathway Glioma
title_sort neuroimmune regulation and potential therapeutic strategies of optic pathway glioma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605541/
https://www.ncbi.nlm.nih.gov/pubmed/37891793
http://dx.doi.org/10.3390/brainsci13101424
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