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Peritoneal Carcinoma Unveiling a Hidden Threat: A Case of Malignant Pericardial Effusion

Malignant pericardial effusion (MPE) is a slowly progressive and potentially clinically silent condition. Pericardial effusion can arise in oncology patients due to several factors, including disease spreading directly or metastatically, anticancer therapy side effects, or both. Solid and hematologi...

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Autores principales: Abusuliman, Mohammed, Mohamed, Amr M, Mahmoud, Anas, Beliani, Tala, Ismail-Sayed, Ibrahim M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605546/
https://www.ncbi.nlm.nih.gov/pubmed/37900376
http://dx.doi.org/10.7759/cureus.46059
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author Abusuliman, Mohammed
Mohamed, Amr M
Mahmoud, Anas
Beliani, Tala
Ismail-Sayed, Ibrahim M
author_facet Abusuliman, Mohammed
Mohamed, Amr M
Mahmoud, Anas
Beliani, Tala
Ismail-Sayed, Ibrahim M
author_sort Abusuliman, Mohammed
collection PubMed
description Malignant pericardial effusion (MPE) is a slowly progressive and potentially clinically silent condition. Pericardial effusion can arise in oncology patients due to several factors, including disease spreading directly or metastatically, anticancer therapy side effects, or both. Solid and hematological malignancy metastasis more frequently involves the pericardium than primary tumors, with lung cancer being the most common metastatic tumor to involve the pericardium. While 5%-20% of all patients with metastatic neoplasms have pericardial involvement, MPE rarely appears with hemodynamic instability. Occasionally, MPE constitutes the initial manifestation of an underlying malignancy. Diagnosis and treatment require a multidisciplinary approach and a high degree of clinical suspicion. We present a case of a 59-year-old female with a history of peritoneal carcinoma who presented with persistent dyspnea on exertion following an episode of pneumonia that was treated with antibiotics. Physical examination and bedside point-of-care ultrasound (POCUS) revealed fluid in the pericardial sac. The cytological examination of the fluid revealed it to be of malignant origin, resulting from metastasis from gynecologic adenocarcinoma. Pericardiocentesis was done, and symptoms improved after fluid drainage.
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spelling pubmed-106055462023-10-28 Peritoneal Carcinoma Unveiling a Hidden Threat: A Case of Malignant Pericardial Effusion Abusuliman, Mohammed Mohamed, Amr M Mahmoud, Anas Beliani, Tala Ismail-Sayed, Ibrahim M Cureus Internal Medicine Malignant pericardial effusion (MPE) is a slowly progressive and potentially clinically silent condition. Pericardial effusion can arise in oncology patients due to several factors, including disease spreading directly or metastatically, anticancer therapy side effects, or both. Solid and hematological malignancy metastasis more frequently involves the pericardium than primary tumors, with lung cancer being the most common metastatic tumor to involve the pericardium. While 5%-20% of all patients with metastatic neoplasms have pericardial involvement, MPE rarely appears with hemodynamic instability. Occasionally, MPE constitutes the initial manifestation of an underlying malignancy. Diagnosis and treatment require a multidisciplinary approach and a high degree of clinical suspicion. We present a case of a 59-year-old female with a history of peritoneal carcinoma who presented with persistent dyspnea on exertion following an episode of pneumonia that was treated with antibiotics. Physical examination and bedside point-of-care ultrasound (POCUS) revealed fluid in the pericardial sac. The cytological examination of the fluid revealed it to be of malignant origin, resulting from metastasis from gynecologic adenocarcinoma. Pericardiocentesis was done, and symptoms improved after fluid drainage. Cureus 2023-09-27 /pmc/articles/PMC10605546/ /pubmed/37900376 http://dx.doi.org/10.7759/cureus.46059 Text en Copyright © 2023, Abusuliman et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Abusuliman, Mohammed
Mohamed, Amr M
Mahmoud, Anas
Beliani, Tala
Ismail-Sayed, Ibrahim M
Peritoneal Carcinoma Unveiling a Hidden Threat: A Case of Malignant Pericardial Effusion
title Peritoneal Carcinoma Unveiling a Hidden Threat: A Case of Malignant Pericardial Effusion
title_full Peritoneal Carcinoma Unveiling a Hidden Threat: A Case of Malignant Pericardial Effusion
title_fullStr Peritoneal Carcinoma Unveiling a Hidden Threat: A Case of Malignant Pericardial Effusion
title_full_unstemmed Peritoneal Carcinoma Unveiling a Hidden Threat: A Case of Malignant Pericardial Effusion
title_short Peritoneal Carcinoma Unveiling a Hidden Threat: A Case of Malignant Pericardial Effusion
title_sort peritoneal carcinoma unveiling a hidden threat: a case of malignant pericardial effusion
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605546/
https://www.ncbi.nlm.nih.gov/pubmed/37900376
http://dx.doi.org/10.7759/cureus.46059
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