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Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats

Febrile seizure (FS), which occurs as a response to fever, is the most common seizure that occurs in infants and young children. FS is usually accompanied by diverse neuropsychiatric symptoms, including impaired social behaviors; however, research on neuropsychiatric disorders and hippocampal inflam...

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Autores principales: Yu, Yeon Hee, Kim, Seong-Wook, Im, Hyuna, Lee, Yu Ran, Kim, Gun Woo, Ryu, Seongho, Park, Dae-Kyoon, Kim, Duk-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605585/
https://www.ncbi.nlm.nih.gov/pubmed/37887290
http://dx.doi.org/10.3390/cells12202446
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author Yu, Yeon Hee
Kim, Seong-Wook
Im, Hyuna
Lee, Yu Ran
Kim, Gun Woo
Ryu, Seongho
Park, Dae-Kyoon
Kim, Duk-Soo
author_facet Yu, Yeon Hee
Kim, Seong-Wook
Im, Hyuna
Lee, Yu Ran
Kim, Gun Woo
Ryu, Seongho
Park, Dae-Kyoon
Kim, Duk-Soo
author_sort Yu, Yeon Hee
collection PubMed
description Febrile seizure (FS), which occurs as a response to fever, is the most common seizure that occurs in infants and young children. FS is usually accompanied by diverse neuropsychiatric symptoms, including impaired social behaviors; however, research on neuropsychiatric disorders and hippocampal inflammatory changes following febrile seizure occurrences is very limited. Here, we provide evidence linking FS occurrence with ASD pathogenesis in rats. We developed an FS juvenile rats model and found ASD-like abnormal behaviors including deficits in social novelty, repetitive behaviors, and hyperlocomotion. In addition, FS model juvenile rats showed enhanced levels of gliosis and inflammation in the hippocampal CA2 region and cerebellum. Furthermore, abnormal levels of social and repetitive behaviors persisted in adults FS model rats. These findings suggest that the inflammatory response triggered by febrile seizures in young children could potentially serve as a mediator of social cognitive impairments.
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spelling pubmed-106055852023-10-28 Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats Yu, Yeon Hee Kim, Seong-Wook Im, Hyuna Lee, Yu Ran Kim, Gun Woo Ryu, Seongho Park, Dae-Kyoon Kim, Duk-Soo Cells Article Febrile seizure (FS), which occurs as a response to fever, is the most common seizure that occurs in infants and young children. FS is usually accompanied by diverse neuropsychiatric symptoms, including impaired social behaviors; however, research on neuropsychiatric disorders and hippocampal inflammatory changes following febrile seizure occurrences is very limited. Here, we provide evidence linking FS occurrence with ASD pathogenesis in rats. We developed an FS juvenile rats model and found ASD-like abnormal behaviors including deficits in social novelty, repetitive behaviors, and hyperlocomotion. In addition, FS model juvenile rats showed enhanced levels of gliosis and inflammation in the hippocampal CA2 region and cerebellum. Furthermore, abnormal levels of social and repetitive behaviors persisted in adults FS model rats. These findings suggest that the inflammatory response triggered by febrile seizures in young children could potentially serve as a mediator of social cognitive impairments. MDPI 2023-10-13 /pmc/articles/PMC10605585/ /pubmed/37887290 http://dx.doi.org/10.3390/cells12202446 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Yu, Yeon Hee
Kim, Seong-Wook
Im, Hyuna
Lee, Yu Ran
Kim, Gun Woo
Ryu, Seongho
Park, Dae-Kyoon
Kim, Duk-Soo
Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats
title Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats
title_full Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats
title_fullStr Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats
title_full_unstemmed Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats
title_short Febrile Seizure Causes Deficit in Social Novelty, Gliosis, and Proinflammatory Cytokine Response in the Hippocampal CA2 Region in Rats
title_sort febrile seizure causes deficit in social novelty, gliosis, and proinflammatory cytokine response in the hippocampal ca2 region in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605585/
https://www.ncbi.nlm.nih.gov/pubmed/37887290
http://dx.doi.org/10.3390/cells12202446
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