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Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas

SIMPLE SUMMARY: Curative-intent definitive treatment for chordoma and chondrosarcoma includes surgery, radiotherapy, or both. In patients with high-volume tumors, unresectable tumors, or recurrent disease, carbon ion radiotherapy has been used to reduce both relapse and treatment sequelae. Because o...

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Autores principales: Holtzman, Adam L., Seidensaal, Katharina, Iannalfi, Alberto, Kim, Kyung Hwan, Koto, Masashi, Yang, Wan-Chin, Shiau, Cheng-Ying, Mahajan, Anita, Ahmed, Safia K., Trifiletti, Daniel M., Peterson, Jennifer L., Koffler, Daniel M., Vallow, Laura A., Hoppe, Bradford S., Rutenberg, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605639/
https://www.ncbi.nlm.nih.gov/pubmed/37894388
http://dx.doi.org/10.3390/cancers15205021
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author Holtzman, Adam L.
Seidensaal, Katharina
Iannalfi, Alberto
Kim, Kyung Hwan
Koto, Masashi
Yang, Wan-Chin
Shiau, Cheng-Ying
Mahajan, Anita
Ahmed, Safia K.
Trifiletti, Daniel M.
Peterson, Jennifer L.
Koffler, Daniel M.
Vallow, Laura A.
Hoppe, Bradford S.
Rutenberg, Michael S.
author_facet Holtzman, Adam L.
Seidensaal, Katharina
Iannalfi, Alberto
Kim, Kyung Hwan
Koto, Masashi
Yang, Wan-Chin
Shiau, Cheng-Ying
Mahajan, Anita
Ahmed, Safia K.
Trifiletti, Daniel M.
Peterson, Jennifer L.
Koffler, Daniel M.
Vallow, Laura A.
Hoppe, Bradford S.
Rutenberg, Michael S.
author_sort Holtzman, Adam L.
collection PubMed
description SIMPLE SUMMARY: Curative-intent definitive treatment for chordoma and chondrosarcoma includes surgery, radiotherapy, or both. In patients with high-volume tumors, unresectable tumors, or recurrent disease, carbon ion radiotherapy has been used to reduce both relapse and treatment sequelae. Because of the limited number of carbon centers worldwide, there is difficulty in accumulating data and providing consensus guidance for its clinical use. Herein, we describe the clinical evidence to date and provide both a graded review of the available evidence and international summary recommendations for the indications of carbon ion radiotherapy in skull-base chordoma and chondrosarcoma. ABSTRACT: Skull-base chordoma and chondrosarcoma are rare radioresistant tumors treated with surgical resection and/or radiotherapy. Because of the established dosimetric and biological benefits of heavy particle therapy, we performed a systematic and evidence-based review of the clinical outcomes of patients with skull-base chordoma and chondrosarcoma treated with carbon ion radiotherapy (CIRT). A literature review was performed using a MEDLINE search of all articles to date. We identified 227 studies as appropriate for review, and 24 were ultimately included. The published data illustrate that CIRT provides benchmark disease control outcomes for skull-base chordoma and chondrosarcoma, respectively, with acceptable toxicity. CIRT is an advanced treatment technique that may provide not only dosimetric benefits over conventional photon therapy but also biologic intensification to overcome mechanisms of radioresistance. Ongoing research is needed to define the magnitude of benefit, patient selection, and cost-effectiveness of CIRT compared to other forms of radiotherapy.
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spelling pubmed-106056392023-10-28 Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas Holtzman, Adam L. Seidensaal, Katharina Iannalfi, Alberto Kim, Kyung Hwan Koto, Masashi Yang, Wan-Chin Shiau, Cheng-Ying Mahajan, Anita Ahmed, Safia K. Trifiletti, Daniel M. Peterson, Jennifer L. Koffler, Daniel M. Vallow, Laura A. Hoppe, Bradford S. Rutenberg, Michael S. Cancers (Basel) Systematic Review SIMPLE SUMMARY: Curative-intent definitive treatment for chordoma and chondrosarcoma includes surgery, radiotherapy, or both. In patients with high-volume tumors, unresectable tumors, or recurrent disease, carbon ion radiotherapy has been used to reduce both relapse and treatment sequelae. Because of the limited number of carbon centers worldwide, there is difficulty in accumulating data and providing consensus guidance for its clinical use. Herein, we describe the clinical evidence to date and provide both a graded review of the available evidence and international summary recommendations for the indications of carbon ion radiotherapy in skull-base chordoma and chondrosarcoma. ABSTRACT: Skull-base chordoma and chondrosarcoma are rare radioresistant tumors treated with surgical resection and/or radiotherapy. Because of the established dosimetric and biological benefits of heavy particle therapy, we performed a systematic and evidence-based review of the clinical outcomes of patients with skull-base chordoma and chondrosarcoma treated with carbon ion radiotherapy (CIRT). A literature review was performed using a MEDLINE search of all articles to date. We identified 227 studies as appropriate for review, and 24 were ultimately included. The published data illustrate that CIRT provides benchmark disease control outcomes for skull-base chordoma and chondrosarcoma, respectively, with acceptable toxicity. CIRT is an advanced treatment technique that may provide not only dosimetric benefits over conventional photon therapy but also biologic intensification to overcome mechanisms of radioresistance. Ongoing research is needed to define the magnitude of benefit, patient selection, and cost-effectiveness of CIRT compared to other forms of radiotherapy. MDPI 2023-10-17 /pmc/articles/PMC10605639/ /pubmed/37894388 http://dx.doi.org/10.3390/cancers15205021 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Holtzman, Adam L.
Seidensaal, Katharina
Iannalfi, Alberto
Kim, Kyung Hwan
Koto, Masashi
Yang, Wan-Chin
Shiau, Cheng-Ying
Mahajan, Anita
Ahmed, Safia K.
Trifiletti, Daniel M.
Peterson, Jennifer L.
Koffler, Daniel M.
Vallow, Laura A.
Hoppe, Bradford S.
Rutenberg, Michael S.
Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas
title Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas
title_full Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas
title_fullStr Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas
title_full_unstemmed Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas
title_short Carbon Ion Radiotherapy: An Evidence-Based Review and Summary Recommendations of Clinical Outcomes for Skull-Base Chordomas and Chondrosarcomas
title_sort carbon ion radiotherapy: an evidence-based review and summary recommendations of clinical outcomes for skull-base chordomas and chondrosarcomas
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605639/
https://www.ncbi.nlm.nih.gov/pubmed/37894388
http://dx.doi.org/10.3390/cancers15205021
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