MTH1 Inhibition Alleviates Immune Suppression and Enhances the Efficacy of Anti-PD-L1 Immunotherapy in Experimental Mesothelioma

SIMPLE SUMMARY: The role of MTH1 in the tumor-related immune responses in mesothelioma remains unknown. We hypothesized that MTH1 regulates immune responses and enhances the efficacy of anti-PD-L1 immunotherapy. We focused on central immune players such as tumor-associated macrophages. MTH1 inhibiti...

Descripción completa

Detalles Bibliográficos
Autores principales: Magkouta, Sophia F., Vaitsi, Photene C., Iliopoulou, Marianthi P., Pappas, Apostolos G., Kosti, Chrysavgi N., Psarra, Katherina, Kalomenidis, Ioannis T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605650/
https://www.ncbi.nlm.nih.gov/pubmed/37894329
http://dx.doi.org/10.3390/cancers15204962

Ejemplares similares

Ejemplares similares