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Exploring Utilization and Establishing Reference Intervals for the Apolipoprotein B Test in the Korean Population

We investigated the reference intervals for Apolipoprotein B (ApoB), a valuable biomarker for cardiovascular diseases, in Korean adults who had undergone health check-ups and showed normal lipid levels under traditional lipid tests, including total cholesterol, triglyceride, and high-density lipopro...

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Autores principales: Choi, Rihwa, Lee, Sang Gon, Lee, Eun Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605768/
https://www.ncbi.nlm.nih.gov/pubmed/37892015
http://dx.doi.org/10.3390/diagnostics13203194
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author Choi, Rihwa
Lee, Sang Gon
Lee, Eun Hee
author_facet Choi, Rihwa
Lee, Sang Gon
Lee, Eun Hee
author_sort Choi, Rihwa
collection PubMed
description We investigated the reference intervals for Apolipoprotein B (ApoB), a valuable biomarker for cardiovascular diseases, in Korean adults who had undergone health check-ups and showed normal lipid levels under traditional lipid tests, including total cholesterol, triglyceride, and high-density lipoprotein cholesterol, along with ApoB. We compared the findings with different cutoffs for ApoB from international clinical guidelines. Among a total of 264,105 traditional lipid test sets, only 464 (0.2%) included ApoB tests, indicating underutilization of this test in health check-up clinics in Korea. From these 464 samples, 334 ApoB results (164 men and 170 women) with normal traditional lipid test results were used to establish reference intervals. Using the parametric method (mean ± 2 SD), the reference intervals ranged from 46 to 134 mg/dL for men and 49 to 129 mg/dL for women. Employing the non-parametric method (central 95th percentile value), the reference intervals ranged from 50 to 131 mg/dL for men and 51 to 127 mg/dL for women. The prevalence of high ApoB did not significantly differ by sex when considering the established reference intervals for each sex and the cutoffs recommended by international clinical guidelines. This study enhances knowledge on ApoB reference intervals in the Korean population, and it will in aid test result interpretation for clinicians and laboratories.
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spelling pubmed-106057682023-10-28 Exploring Utilization and Establishing Reference Intervals for the Apolipoprotein B Test in the Korean Population Choi, Rihwa Lee, Sang Gon Lee, Eun Hee Diagnostics (Basel) Communication We investigated the reference intervals for Apolipoprotein B (ApoB), a valuable biomarker for cardiovascular diseases, in Korean adults who had undergone health check-ups and showed normal lipid levels under traditional lipid tests, including total cholesterol, triglyceride, and high-density lipoprotein cholesterol, along with ApoB. We compared the findings with different cutoffs for ApoB from international clinical guidelines. Among a total of 264,105 traditional lipid test sets, only 464 (0.2%) included ApoB tests, indicating underutilization of this test in health check-up clinics in Korea. From these 464 samples, 334 ApoB results (164 men and 170 women) with normal traditional lipid test results were used to establish reference intervals. Using the parametric method (mean ± 2 SD), the reference intervals ranged from 46 to 134 mg/dL for men and 49 to 129 mg/dL for women. Employing the non-parametric method (central 95th percentile value), the reference intervals ranged from 50 to 131 mg/dL for men and 51 to 127 mg/dL for women. The prevalence of high ApoB did not significantly differ by sex when considering the established reference intervals for each sex and the cutoffs recommended by international clinical guidelines. This study enhances knowledge on ApoB reference intervals in the Korean population, and it will in aid test result interpretation for clinicians and laboratories. MDPI 2023-10-12 /pmc/articles/PMC10605768/ /pubmed/37892015 http://dx.doi.org/10.3390/diagnostics13203194 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Choi, Rihwa
Lee, Sang Gon
Lee, Eun Hee
Exploring Utilization and Establishing Reference Intervals for the Apolipoprotein B Test in the Korean Population
title Exploring Utilization and Establishing Reference Intervals for the Apolipoprotein B Test in the Korean Population
title_full Exploring Utilization and Establishing Reference Intervals for the Apolipoprotein B Test in the Korean Population
title_fullStr Exploring Utilization and Establishing Reference Intervals for the Apolipoprotein B Test in the Korean Population
title_full_unstemmed Exploring Utilization and Establishing Reference Intervals for the Apolipoprotein B Test in the Korean Population
title_short Exploring Utilization and Establishing Reference Intervals for the Apolipoprotein B Test in the Korean Population
title_sort exploring utilization and establishing reference intervals for the apolipoprotein b test in the korean population
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10605768/
https://www.ncbi.nlm.nih.gov/pubmed/37892015
http://dx.doi.org/10.3390/diagnostics13203194
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