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S100 Proteins in the Pathogenesis of Psoriasis and Atopic Dermatitis

The skin, the outermost layer of the human body, is exposed to various external stimuli that cause inflammatory skin reactions. These external stimulants trigger external epithelial cell damage and the release of intracellular substances. Following cellular damage or death, intracellular molecules a...

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Detalles Bibliográficos
Autores principales: Saito-Sasaki, Natsuko, Sawada, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606049/
https://www.ncbi.nlm.nih.gov/pubmed/37891988
http://dx.doi.org/10.3390/diagnostics13203167
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author Saito-Sasaki, Natsuko
Sawada, Yu
author_facet Saito-Sasaki, Natsuko
Sawada, Yu
author_sort Saito-Sasaki, Natsuko
collection PubMed
description The skin, the outermost layer of the human body, is exposed to various external stimuli that cause inflammatory skin reactions. These external stimulants trigger external epithelial cell damage and the release of intracellular substances. Following cellular damage or death, intracellular molecules are released that enhance tissue inflammation. As an important substance released from damaged cells, the S100 protein is a low-molecular-weight acidic protein with two calcium-binding sites and EF-hand motif domains. S100 proteins are widely present in systemic organs and interact with other proteins. Recent studies revealed the involvement of S100 in cutaneous inflammatory disorders, psoriasis, and atopic dermatitis. This review provides detailed information on the interactions among various S100 proteins in inflammatory diseases.
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spelling pubmed-106060492023-10-28 S100 Proteins in the Pathogenesis of Psoriasis and Atopic Dermatitis Saito-Sasaki, Natsuko Sawada, Yu Diagnostics (Basel) Review The skin, the outermost layer of the human body, is exposed to various external stimuli that cause inflammatory skin reactions. These external stimulants trigger external epithelial cell damage and the release of intracellular substances. Following cellular damage or death, intracellular molecules are released that enhance tissue inflammation. As an important substance released from damaged cells, the S100 protein is a low-molecular-weight acidic protein with two calcium-binding sites and EF-hand motif domains. S100 proteins are widely present in systemic organs and interact with other proteins. Recent studies revealed the involvement of S100 in cutaneous inflammatory disorders, psoriasis, and atopic dermatitis. This review provides detailed information on the interactions among various S100 proteins in inflammatory diseases. MDPI 2023-10-10 /pmc/articles/PMC10606049/ /pubmed/37891988 http://dx.doi.org/10.3390/diagnostics13203167 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saito-Sasaki, Natsuko
Sawada, Yu
S100 Proteins in the Pathogenesis of Psoriasis and Atopic Dermatitis
title S100 Proteins in the Pathogenesis of Psoriasis and Atopic Dermatitis
title_full S100 Proteins in the Pathogenesis of Psoriasis and Atopic Dermatitis
title_fullStr S100 Proteins in the Pathogenesis of Psoriasis and Atopic Dermatitis
title_full_unstemmed S100 Proteins in the Pathogenesis of Psoriasis and Atopic Dermatitis
title_short S100 Proteins in the Pathogenesis of Psoriasis and Atopic Dermatitis
title_sort s100 proteins in the pathogenesis of psoriasis and atopic dermatitis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606049/
https://www.ncbi.nlm.nih.gov/pubmed/37891988
http://dx.doi.org/10.3390/diagnostics13203167
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