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Optimizing Inference Distribution for Efficient Kidney Tumor Segmentation Using a UNet-PWP Deep-Learning Model with XAI on CT Scan Images

Kidney tumors represent a significant medical challenge, characterized by their often-asymptomatic nature and the need for early detection to facilitate timely and effective intervention. Although neural networks have shown great promise in disease prediction, their computational demands have limite...

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Autores principales: Rao, P. Kiran, Chatterjee, Subarna, Janardhan, M., Nagaraju, K., Khan, Surbhi Bhatia, Almusharraf, Ahlam, Alharbe, Abdullah I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606269/
https://www.ncbi.nlm.nih.gov/pubmed/37892065
http://dx.doi.org/10.3390/diagnostics13203244
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author Rao, P. Kiran
Chatterjee, Subarna
Janardhan, M.
Nagaraju, K.
Khan, Surbhi Bhatia
Almusharraf, Ahlam
Alharbe, Abdullah I.
author_facet Rao, P. Kiran
Chatterjee, Subarna
Janardhan, M.
Nagaraju, K.
Khan, Surbhi Bhatia
Almusharraf, Ahlam
Alharbe, Abdullah I.
author_sort Rao, P. Kiran
collection PubMed
description Kidney tumors represent a significant medical challenge, characterized by their often-asymptomatic nature and the need for early detection to facilitate timely and effective intervention. Although neural networks have shown great promise in disease prediction, their computational demands have limited their practicality in clinical settings. This study introduces a novel methodology, the UNet-PWP architecture, tailored explicitly for kidney tumor segmentation, designed to optimize resource utilization and overcome computational complexity constraints. A key novelty in our approach is the application of adaptive partitioning, which deconstructs the intricate UNet architecture into smaller submodels. This partitioning strategy reduces computational requirements and enhances the model’s efficiency in processing kidney tumor images. Additionally, we augment the UNet’s depth by incorporating pre-trained weights, therefore significantly boosting its capacity to handle intricate and detailed segmentation tasks. Furthermore, we employ weight-pruning techniques to eliminate redundant zero-weighted parameters, further streamlining the UNet-PWP model without compromising its performance. To rigorously assess the effectiveness of our proposed UNet-PWP model, we conducted a comparative evaluation alongside the DeepLab V3+ model, both trained on the “KiTs 19, 21, and 23” kidney tumor dataset. Our results are optimistic, with the UNet-PWP model achieving an exceptional accuracy rate of 97.01% on both the training and test datasets, surpassing the DeepLab V3+ model in performance. Furthermore, to ensure our model’s results are easily understandable and explainable. We included a fusion of the attention and Grad-CAM XAI methods. This approach provides valuable insights into the decision-making process of our model and the regions of interest that affect its predictions. In the medical field, this interpretability aspect is crucial for healthcare professionals to trust and comprehend the model’s reasoning.
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spelling pubmed-106062692023-10-28 Optimizing Inference Distribution for Efficient Kidney Tumor Segmentation Using a UNet-PWP Deep-Learning Model with XAI on CT Scan Images Rao, P. Kiran Chatterjee, Subarna Janardhan, M. Nagaraju, K. Khan, Surbhi Bhatia Almusharraf, Ahlam Alharbe, Abdullah I. Diagnostics (Basel) Article Kidney tumors represent a significant medical challenge, characterized by their often-asymptomatic nature and the need for early detection to facilitate timely and effective intervention. Although neural networks have shown great promise in disease prediction, their computational demands have limited their practicality in clinical settings. This study introduces a novel methodology, the UNet-PWP architecture, tailored explicitly for kidney tumor segmentation, designed to optimize resource utilization and overcome computational complexity constraints. A key novelty in our approach is the application of adaptive partitioning, which deconstructs the intricate UNet architecture into smaller submodels. This partitioning strategy reduces computational requirements and enhances the model’s efficiency in processing kidney tumor images. Additionally, we augment the UNet’s depth by incorporating pre-trained weights, therefore significantly boosting its capacity to handle intricate and detailed segmentation tasks. Furthermore, we employ weight-pruning techniques to eliminate redundant zero-weighted parameters, further streamlining the UNet-PWP model without compromising its performance. To rigorously assess the effectiveness of our proposed UNet-PWP model, we conducted a comparative evaluation alongside the DeepLab V3+ model, both trained on the “KiTs 19, 21, and 23” kidney tumor dataset. Our results are optimistic, with the UNet-PWP model achieving an exceptional accuracy rate of 97.01% on both the training and test datasets, surpassing the DeepLab V3+ model in performance. Furthermore, to ensure our model’s results are easily understandable and explainable. We included a fusion of the attention and Grad-CAM XAI methods. This approach provides valuable insights into the decision-making process of our model and the regions of interest that affect its predictions. In the medical field, this interpretability aspect is crucial for healthcare professionals to trust and comprehend the model’s reasoning. MDPI 2023-10-18 /pmc/articles/PMC10606269/ /pubmed/37892065 http://dx.doi.org/10.3390/diagnostics13203244 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rao, P. Kiran
Chatterjee, Subarna
Janardhan, M.
Nagaraju, K.
Khan, Surbhi Bhatia
Almusharraf, Ahlam
Alharbe, Abdullah I.
Optimizing Inference Distribution for Efficient Kidney Tumor Segmentation Using a UNet-PWP Deep-Learning Model with XAI on CT Scan Images
title Optimizing Inference Distribution for Efficient Kidney Tumor Segmentation Using a UNet-PWP Deep-Learning Model with XAI on CT Scan Images
title_full Optimizing Inference Distribution for Efficient Kidney Tumor Segmentation Using a UNet-PWP Deep-Learning Model with XAI on CT Scan Images
title_fullStr Optimizing Inference Distribution for Efficient Kidney Tumor Segmentation Using a UNet-PWP Deep-Learning Model with XAI on CT Scan Images
title_full_unstemmed Optimizing Inference Distribution for Efficient Kidney Tumor Segmentation Using a UNet-PWP Deep-Learning Model with XAI on CT Scan Images
title_short Optimizing Inference Distribution for Efficient Kidney Tumor Segmentation Using a UNet-PWP Deep-Learning Model with XAI on CT Scan Images
title_sort optimizing inference distribution for efficient kidney tumor segmentation using a unet-pwp deep-learning model with xai on ct scan images
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606269/
https://www.ncbi.nlm.nih.gov/pubmed/37892065
http://dx.doi.org/10.3390/diagnostics13203244
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