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Double Cross-Linked Chitosan/Bacterial Cellulose Dressing with Self-Healable Ability
Self-healing hydrogel products have attracted a great deal of interest in wound healing due to their ability to repair their own structural damage. Herein, an all-natural self-healing hydrogel based on methacrylated chitosan (CSMA) and dialdehyde bacterial cellulose (DABC) is developed. MA is used t...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606276/ https://www.ncbi.nlm.nih.gov/pubmed/37888346 http://dx.doi.org/10.3390/gels9100772 |
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author | Deng, Lili Ou, Kangkang Shen, Jiaxin Wang, Baoxiu Chen, Shiyan Wang, Huaping Gu, Song |
author_facet | Deng, Lili Ou, Kangkang Shen, Jiaxin Wang, Baoxiu Chen, Shiyan Wang, Huaping Gu, Song |
author_sort | Deng, Lili |
collection | PubMed |
description | Self-healing hydrogel products have attracted a great deal of interest in wound healing due to their ability to repair their own structural damage. Herein, an all-natural self-healing hydrogel based on methacrylated chitosan (CSMA) and dialdehyde bacterial cellulose (DABC) is developed. MA is used to modify CS and obtain water-soluble biomaterial-based CSMA with photo crosslinking effects. BC is modified through a simple oxidation method to gain dialdehyde on the polymer chain. The success of the modification is confirmed via FTIR. Hydrogels are formed within 11 min through the establishment of a Schiff base between the amino of CSMA and the aldehyde of DABC. A dynamically reversible Schiff base bond endows hydrogel with good self-healing properties through macroscopic and microscopic observations. We observe the uniform and porous structure in the hydrogel using SEM images, and DABC nanofibers are found to be well distributed in the hydrogel. The compressive strength of the hydrogel is more than 20 kPa and the swelling rate sees over a 10-fold increase. In addition, the CSMA/DABC hydrogel has good cytocompatibility, with cell viability exceeding 90%. These results indicate that the all-natural self-healable CSMA/DABC hydrogel demonstrates strong application potential in wound healing and tissue repair. |
format | Online Article Text |
id | pubmed-10606276 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106062762023-10-28 Double Cross-Linked Chitosan/Bacterial Cellulose Dressing with Self-Healable Ability Deng, Lili Ou, Kangkang Shen, Jiaxin Wang, Baoxiu Chen, Shiyan Wang, Huaping Gu, Song Gels Article Self-healing hydrogel products have attracted a great deal of interest in wound healing due to their ability to repair their own structural damage. Herein, an all-natural self-healing hydrogel based on methacrylated chitosan (CSMA) and dialdehyde bacterial cellulose (DABC) is developed. MA is used to modify CS and obtain water-soluble biomaterial-based CSMA with photo crosslinking effects. BC is modified through a simple oxidation method to gain dialdehyde on the polymer chain. The success of the modification is confirmed via FTIR. Hydrogels are formed within 11 min through the establishment of a Schiff base between the amino of CSMA and the aldehyde of DABC. A dynamically reversible Schiff base bond endows hydrogel with good self-healing properties through macroscopic and microscopic observations. We observe the uniform and porous structure in the hydrogel using SEM images, and DABC nanofibers are found to be well distributed in the hydrogel. The compressive strength of the hydrogel is more than 20 kPa and the swelling rate sees over a 10-fold increase. In addition, the CSMA/DABC hydrogel has good cytocompatibility, with cell viability exceeding 90%. These results indicate that the all-natural self-healable CSMA/DABC hydrogel demonstrates strong application potential in wound healing and tissue repair. MDPI 2023-09-22 /pmc/articles/PMC10606276/ /pubmed/37888346 http://dx.doi.org/10.3390/gels9100772 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Deng, Lili Ou, Kangkang Shen, Jiaxin Wang, Baoxiu Chen, Shiyan Wang, Huaping Gu, Song Double Cross-Linked Chitosan/Bacterial Cellulose Dressing with Self-Healable Ability |
title | Double Cross-Linked Chitosan/Bacterial Cellulose Dressing with Self-Healable Ability |
title_full | Double Cross-Linked Chitosan/Bacterial Cellulose Dressing with Self-Healable Ability |
title_fullStr | Double Cross-Linked Chitosan/Bacterial Cellulose Dressing with Self-Healable Ability |
title_full_unstemmed | Double Cross-Linked Chitosan/Bacterial Cellulose Dressing with Self-Healable Ability |
title_short | Double Cross-Linked Chitosan/Bacterial Cellulose Dressing with Self-Healable Ability |
title_sort | double cross-linked chitosan/bacterial cellulose dressing with self-healable ability |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606276/ https://www.ncbi.nlm.nih.gov/pubmed/37888346 http://dx.doi.org/10.3390/gels9100772 |
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