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Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy—An Updated Review of Diagnostic Approaches and Treatments

Food-dependent exercise-induced allergic reactions (FDEIA) represent a distinct clinical phenomenon where symptoms arise during exercise following the consumption of specific trigger foods, with the most severe manifestation being anaphylaxis—a condition distinct from typical exercise-induced or foo...

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Autores principales: Srisuwatchari, Witchaya, Kanchanaphoomi, Kantima, Nawiboonwong, Jutamard, Thongngarm, Torpong, Sompornrattanaphan, Mongkhon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606284/
https://www.ncbi.nlm.nih.gov/pubmed/37893663
http://dx.doi.org/10.3390/foods12203768
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author Srisuwatchari, Witchaya
Kanchanaphoomi, Kantima
Nawiboonwong, Jutamard
Thongngarm, Torpong
Sompornrattanaphan, Mongkhon
author_facet Srisuwatchari, Witchaya
Kanchanaphoomi, Kantima
Nawiboonwong, Jutamard
Thongngarm, Torpong
Sompornrattanaphan, Mongkhon
author_sort Srisuwatchari, Witchaya
collection PubMed
description Food-dependent exercise-induced allergic reactions (FDEIA) represent a distinct clinical phenomenon where symptoms arise during exercise following the consumption of specific trigger foods, with the most severe manifestation being anaphylaxis—a condition distinct from typical exercise-induced or food-induced anaphylaxis. In FDEIA, patients can either exercise or tolerate specific foods separately without experiencing any allergic reactions. Diagnosis relies on patient history and provocation testing, requiring rigorous implementation within a supervised hospital environment. Positive symptoms and clinical signs during testing confirm FDEIA, while negative outcomes do not preclude its presence. Exercise stands as the primary trigger, followed by nonsteroidal anti-inflammatory drugs (NSAIDs) and alcohol. The utilization of various protocols for food cofactor challenges to confirm FDEIA yields differing diagnostic outcomes. We highlight the updated concept of food cofactor challenges, incorporating protocols reported in the literature, and summarize current recommendations and comprehensive management approaches for FDEIA patients.
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spelling pubmed-106062842023-10-28 Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy—An Updated Review of Diagnostic Approaches and Treatments Srisuwatchari, Witchaya Kanchanaphoomi, Kantima Nawiboonwong, Jutamard Thongngarm, Torpong Sompornrattanaphan, Mongkhon Foods Review Food-dependent exercise-induced allergic reactions (FDEIA) represent a distinct clinical phenomenon where symptoms arise during exercise following the consumption of specific trigger foods, with the most severe manifestation being anaphylaxis—a condition distinct from typical exercise-induced or food-induced anaphylaxis. In FDEIA, patients can either exercise or tolerate specific foods separately without experiencing any allergic reactions. Diagnosis relies on patient history and provocation testing, requiring rigorous implementation within a supervised hospital environment. Positive symptoms and clinical signs during testing confirm FDEIA, while negative outcomes do not preclude its presence. Exercise stands as the primary trigger, followed by nonsteroidal anti-inflammatory drugs (NSAIDs) and alcohol. The utilization of various protocols for food cofactor challenges to confirm FDEIA yields differing diagnostic outcomes. We highlight the updated concept of food cofactor challenges, incorporating protocols reported in the literature, and summarize current recommendations and comprehensive management approaches for FDEIA patients. MDPI 2023-10-13 /pmc/articles/PMC10606284/ /pubmed/37893663 http://dx.doi.org/10.3390/foods12203768 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Srisuwatchari, Witchaya
Kanchanaphoomi, Kantima
Nawiboonwong, Jutamard
Thongngarm, Torpong
Sompornrattanaphan, Mongkhon
Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy—An Updated Review of Diagnostic Approaches and Treatments
title Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy—An Updated Review of Diagnostic Approaches and Treatments
title_full Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy—An Updated Review of Diagnostic Approaches and Treatments
title_fullStr Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy—An Updated Review of Diagnostic Approaches and Treatments
title_full_unstemmed Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy—An Updated Review of Diagnostic Approaches and Treatments
title_short Food-Dependent Exercise-Induced Anaphylaxis: A Distinct Form of Food Allergy—An Updated Review of Diagnostic Approaches and Treatments
title_sort food-dependent exercise-induced anaphylaxis: a distinct form of food allergy—an updated review of diagnostic approaches and treatments
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606284/
https://www.ncbi.nlm.nih.gov/pubmed/37893663
http://dx.doi.org/10.3390/foods12203768
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