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Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from Hizikia fusiforme

Hizikia fusiforme has a long history of consumption and medicinal use in China. It has been found that natural plants containing polyphenol–polysaccharide complexes have better activity compared with polyphenols and polysaccharides. Therefore, in this study on enzymatic hydrolysis and fractional alc...

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Autores principales: Li, Shangkun, He, Yunhai, Zhong, Saiyi, Li, Yutong, Di, Yuan, Wang, Qiukuan, Ren, Dandan, Liu, Shu, Li, Di, Cao, Fangjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606324/
https://www.ncbi.nlm.nih.gov/pubmed/37893618
http://dx.doi.org/10.3390/foods12203725
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author Li, Shangkun
He, Yunhai
Zhong, Saiyi
Li, Yutong
Di, Yuan
Wang, Qiukuan
Ren, Dandan
Liu, Shu
Li, Di
Cao, Fangjie
author_facet Li, Shangkun
He, Yunhai
Zhong, Saiyi
Li, Yutong
Di, Yuan
Wang, Qiukuan
Ren, Dandan
Liu, Shu
Li, Di
Cao, Fangjie
author_sort Li, Shangkun
collection PubMed
description Hizikia fusiforme has a long history of consumption and medicinal use in China. It has been found that natural plants containing polyphenol–polysaccharide complexes have better activity compared with polyphenols and polysaccharides. Therefore, in this study on enzymatic hydrolysis and fractional alcohol precipitation, two kinds of polyphenol–polysaccharide complexes (PPC), PPC1 and PPC2, were initially obtained from Hizikia fusiforme, while the dephenolization of PPC1 and PPC2 produced PPC3 and PPC4. Through in vitro assays, PPC2 and PPC4 were found to have higher antioxidant activity, and thus were selected for testing the PPCs’ anti-aging activity in a subsequent in vivo experiment with D-gal-induced aging in mice. The results indicated that PPCs could regulate the expressions of antioxidant enzymes and products of oxidation, elevate the expressions of genes and proteins related to the Nrf2 pathway in the mouse brain, enrich the gut microbiota species and increase the Bacteroidota–Firmicute (B/F) ratio. Above all, the Hizikia fusiforme polyphenol–polysaccharide complex has potential in the development of natural anti-aging drugs.
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spelling pubmed-106063242023-10-28 Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from Hizikia fusiforme Li, Shangkun He, Yunhai Zhong, Saiyi Li, Yutong Di, Yuan Wang, Qiukuan Ren, Dandan Liu, Shu Li, Di Cao, Fangjie Foods Article Hizikia fusiforme has a long history of consumption and medicinal use in China. It has been found that natural plants containing polyphenol–polysaccharide complexes have better activity compared with polyphenols and polysaccharides. Therefore, in this study on enzymatic hydrolysis and fractional alcohol precipitation, two kinds of polyphenol–polysaccharide complexes (PPC), PPC1 and PPC2, were initially obtained from Hizikia fusiforme, while the dephenolization of PPC1 and PPC2 produced PPC3 and PPC4. Through in vitro assays, PPC2 and PPC4 were found to have higher antioxidant activity, and thus were selected for testing the PPCs’ anti-aging activity in a subsequent in vivo experiment with D-gal-induced aging in mice. The results indicated that PPCs could regulate the expressions of antioxidant enzymes and products of oxidation, elevate the expressions of genes and proteins related to the Nrf2 pathway in the mouse brain, enrich the gut microbiota species and increase the Bacteroidota–Firmicute (B/F) ratio. Above all, the Hizikia fusiforme polyphenol–polysaccharide complex has potential in the development of natural anti-aging drugs. MDPI 2023-10-10 /pmc/articles/PMC10606324/ /pubmed/37893618 http://dx.doi.org/10.3390/foods12203725 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Shangkun
He, Yunhai
Zhong, Saiyi
Li, Yutong
Di, Yuan
Wang, Qiukuan
Ren, Dandan
Liu, Shu
Li, Di
Cao, Fangjie
Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from Hizikia fusiforme
title Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from Hizikia fusiforme
title_full Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from Hizikia fusiforme
title_fullStr Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from Hizikia fusiforme
title_full_unstemmed Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from Hizikia fusiforme
title_short Antioxidant and Anti-Aging Properties of Polyphenol–Polysaccharide Complex Extract from Hizikia fusiforme
title_sort antioxidant and anti-aging properties of polyphenol–polysaccharide complex extract from hizikia fusiforme
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606324/
https://www.ncbi.nlm.nih.gov/pubmed/37893618
http://dx.doi.org/10.3390/foods12203725
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