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The Value of Micro-CT in the Diagnosis of Lung Carcinoma: A Radio-Histopathological Perspective

Micro-computed tomography (micro-CT) is a relatively new imaging modality and the three-dimensional (3D) images obtained via micro-CT allow researchers to collect both quantitative and qualitative information on various types of samples. Micro-CT could potentially be used to examine human diseases a...

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Autores principales: Dizbay Sak, Serpil, Sevim, Selim, Buyuksungur, Arda, Kayı Cangır, Ayten, Orhan, Kaan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606474/
https://www.ncbi.nlm.nih.gov/pubmed/37892083
http://dx.doi.org/10.3390/diagnostics13203262
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author Dizbay Sak, Serpil
Sevim, Selim
Buyuksungur, Arda
Kayı Cangır, Ayten
Orhan, Kaan
author_facet Dizbay Sak, Serpil
Sevim, Selim
Buyuksungur, Arda
Kayı Cangır, Ayten
Orhan, Kaan
author_sort Dizbay Sak, Serpil
collection PubMed
description Micro-computed tomography (micro-CT) is a relatively new imaging modality and the three-dimensional (3D) images obtained via micro-CT allow researchers to collect both quantitative and qualitative information on various types of samples. Micro-CT could potentially be used to examine human diseases and several studies have been published on this topic in the last decade. In this study, the potential uses of micro-CT in understanding and evaluating lung carcinoma and the relevant studies conducted on lung and other tumors are summarized. Currently, the resolution of benchtop laboratory micro-CT units has not reached the levels that can be obtained with light microscopy, and it is not possible to detect the histopathological features (e.g., tumor type, adenocarcinoma pattern, spread through air spaces) required for lung cancer management. However, its ability to provide 3D images in any plane of section, without disturbing the integrity of the specimen, suggests that it can be used as an auxiliary technique, especially in surgical margin examination, the evaluation of tumor invasion in the entire specimen, and calculation of primary and metastatic tumor volume. Along with future developments in micro-CT technology, it can be expected that the image resolution will gradually improve, the examination time will decrease, and the relevant software will be more user friendly. As a result of these developments, micro-CT may enter pathology laboratories as an auxiliary method in the pathological evaluation of lung tumors. However, the safety, performance, and cost effectiveness of micro-CT in the areas of possible clinical application should be investigated. If micro-CT passes all these tests, it may lead to the convergence of radiology and pathology applications performed independently in separate units today, and the birth of a new type of diagnostician who has equal knowledge of the histological and radiological features of tumors.
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spelling pubmed-106064742023-10-28 The Value of Micro-CT in the Diagnosis of Lung Carcinoma: A Radio-Histopathological Perspective Dizbay Sak, Serpil Sevim, Selim Buyuksungur, Arda Kayı Cangır, Ayten Orhan, Kaan Diagnostics (Basel) Review Micro-computed tomography (micro-CT) is a relatively new imaging modality and the three-dimensional (3D) images obtained via micro-CT allow researchers to collect both quantitative and qualitative information on various types of samples. Micro-CT could potentially be used to examine human diseases and several studies have been published on this topic in the last decade. In this study, the potential uses of micro-CT in understanding and evaluating lung carcinoma and the relevant studies conducted on lung and other tumors are summarized. Currently, the resolution of benchtop laboratory micro-CT units has not reached the levels that can be obtained with light microscopy, and it is not possible to detect the histopathological features (e.g., tumor type, adenocarcinoma pattern, spread through air spaces) required for lung cancer management. However, its ability to provide 3D images in any plane of section, without disturbing the integrity of the specimen, suggests that it can be used as an auxiliary technique, especially in surgical margin examination, the evaluation of tumor invasion in the entire specimen, and calculation of primary and metastatic tumor volume. Along with future developments in micro-CT technology, it can be expected that the image resolution will gradually improve, the examination time will decrease, and the relevant software will be more user friendly. As a result of these developments, micro-CT may enter pathology laboratories as an auxiliary method in the pathological evaluation of lung tumors. However, the safety, performance, and cost effectiveness of micro-CT in the areas of possible clinical application should be investigated. If micro-CT passes all these tests, it may lead to the convergence of radiology and pathology applications performed independently in separate units today, and the birth of a new type of diagnostician who has equal knowledge of the histological and radiological features of tumors. MDPI 2023-10-20 /pmc/articles/PMC10606474/ /pubmed/37892083 http://dx.doi.org/10.3390/diagnostics13203262 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Dizbay Sak, Serpil
Sevim, Selim
Buyuksungur, Arda
Kayı Cangır, Ayten
Orhan, Kaan
The Value of Micro-CT in the Diagnosis of Lung Carcinoma: A Radio-Histopathological Perspective
title The Value of Micro-CT in the Diagnosis of Lung Carcinoma: A Radio-Histopathological Perspective
title_full The Value of Micro-CT in the Diagnosis of Lung Carcinoma: A Radio-Histopathological Perspective
title_fullStr The Value of Micro-CT in the Diagnosis of Lung Carcinoma: A Radio-Histopathological Perspective
title_full_unstemmed The Value of Micro-CT in the Diagnosis of Lung Carcinoma: A Radio-Histopathological Perspective
title_short The Value of Micro-CT in the Diagnosis of Lung Carcinoma: A Radio-Histopathological Perspective
title_sort value of micro-ct in the diagnosis of lung carcinoma: a radio-histopathological perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606474/
https://www.ncbi.nlm.nih.gov/pubmed/37892083
http://dx.doi.org/10.3390/diagnostics13203262
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