Readthrough Approach Using NV Translational Readthrough-Inducing Drugs (TRIDs): A Study of the Possible Off-Target Effects on Natural Termination Codons (NTCs) on TP53 and Housekeeping Gene Expression

Nonsense mutations cause several genetic diseases such as cystic fibrosis, Duchenne muscular dystrophy, β-thalassemia, and Shwachman–Diamond syndrome. These mutations induce the formation of a premature termination codon (PTC) inside the mRNA sequence, resulting in the synthesis of truncated polypep...

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Detalles Bibliográficos
Autores principales: Perriera, Riccardo, Vitale, Emanuele, Pibiri, Ivana, Carollo, Pietro Salvatore, Ricci, Davide, Corrao, Federica, Fiduccia, Ignazio, Melfi, Raffaella, Zizzo, Maria Grazia, Tutone, Marco, Pace, Andrea, Lentini, Laura
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606485/
https://www.ncbi.nlm.nih.gov/pubmed/37894764
http://dx.doi.org/10.3390/ijms242015084

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