Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes
Autism spectrum disorder (ASD) has recently been linked to neuroinflammation and an aberrant immune response within the central nervous system. The intricate relationship between immune response and ASD remains elusive, with a gap in understanding the connection between specific immune mechanisms an...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606637/ https://www.ncbi.nlm.nih.gov/pubmed/37894761 http://dx.doi.org/10.3390/ijms242015080 |
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author | Maric, Dusan M. Vojvodic, Danilo Maric, Dusica L. Velikic, Gordana Radomir, Mihajlo Sokolovac, Ivana Stefik, Debora Ivkovic, Nemanja Susnjevic, Sonja Puletic, Miljan Dulic, Oliver Abazovic, Dzihan |
author_facet | Maric, Dusan M. Vojvodic, Danilo Maric, Dusica L. Velikic, Gordana Radomir, Mihajlo Sokolovac, Ivana Stefik, Debora Ivkovic, Nemanja Susnjevic, Sonja Puletic, Miljan Dulic, Oliver Abazovic, Dzihan |
author_sort | Maric, Dusan M. |
collection | PubMed |
description | Autism spectrum disorder (ASD) has recently been linked to neuroinflammation and an aberrant immune response within the central nervous system. The intricate relationship between immune response and ASD remains elusive, with a gap in understanding the connection between specific immune mechanisms and neural manifestations in autism. In this study, we employed a comprehensive statistical approach, fusing both overarching and granular methods to examine the concentration of 16 cytokines in the cerebrospinal fluid (CSF) across each autologous bone marrow aspirate concentrate (BMAC) intrathecal administration in 63 male and 17 female autism patients. Following a six-month period post the third administration, patients were stratified into three categories based on clinical improvement: Group 1- no/mild (28 subjects), Group 2—moderate (16 subjects), and Group 3—major improvement (15 subjects). Our integrated analysis revealed pronounced disparities in CSF cytokine patterns and clinical outcomes in autism subjects pre- and post-BMAC transplantation. Crucially, our results suggest that these cytokine profiles hold promise as predictive markers, pinpointing ASD individuals who might not exhibit notable clinical amelioration post-BMAC therapy. |
format | Online Article Text |
id | pubmed-10606637 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106066372023-10-28 Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes Maric, Dusan M. Vojvodic, Danilo Maric, Dusica L. Velikic, Gordana Radomir, Mihajlo Sokolovac, Ivana Stefik, Debora Ivkovic, Nemanja Susnjevic, Sonja Puletic, Miljan Dulic, Oliver Abazovic, Dzihan Int J Mol Sci Article Autism spectrum disorder (ASD) has recently been linked to neuroinflammation and an aberrant immune response within the central nervous system. The intricate relationship between immune response and ASD remains elusive, with a gap in understanding the connection between specific immune mechanisms and neural manifestations in autism. In this study, we employed a comprehensive statistical approach, fusing both overarching and granular methods to examine the concentration of 16 cytokines in the cerebrospinal fluid (CSF) across each autologous bone marrow aspirate concentrate (BMAC) intrathecal administration in 63 male and 17 female autism patients. Following a six-month period post the third administration, patients were stratified into three categories based on clinical improvement: Group 1- no/mild (28 subjects), Group 2—moderate (16 subjects), and Group 3—major improvement (15 subjects). Our integrated analysis revealed pronounced disparities in CSF cytokine patterns and clinical outcomes in autism subjects pre- and post-BMAC transplantation. Crucially, our results suggest that these cytokine profiles hold promise as predictive markers, pinpointing ASD individuals who might not exhibit notable clinical amelioration post-BMAC therapy. MDPI 2023-10-11 /pmc/articles/PMC10606637/ /pubmed/37894761 http://dx.doi.org/10.3390/ijms242015080 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Maric, Dusan M. Vojvodic, Danilo Maric, Dusica L. Velikic, Gordana Radomir, Mihajlo Sokolovac, Ivana Stefik, Debora Ivkovic, Nemanja Susnjevic, Sonja Puletic, Miljan Dulic, Oliver Abazovic, Dzihan Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes |
title | Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes |
title_full | Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes |
title_fullStr | Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes |
title_full_unstemmed | Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes |
title_short | Cytokine Dynamics in Autism: Analysis of BMAC Therapy Outcomes |
title_sort | cytokine dynamics in autism: analysis of bmac therapy outcomes |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606637/ https://www.ncbi.nlm.nih.gov/pubmed/37894761 http://dx.doi.org/10.3390/ijms242015080 |
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