Cargando…
Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression
Metabolism and the immunological state are intimately intertwined, as defense responses are bioenergetically expensive. Metabolic homeostasis is a key requirement for the proper function of immune cell subsets, and the perturbation of the immune–metabolic balance is a recurrent event in many human d...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606647/ https://www.ncbi.nlm.nih.gov/pubmed/37895302 http://dx.doi.org/10.3390/genes14101953 |
_version_ | 1785127366084788224 |
---|---|
author | Flati, Irene Di Vito Nolfi, Mauro Dall’Aglio, Francesca Vecchiotti, Davide Verzella, Daniela Alesse, Edoardo Capece, Daria Zazzeroni, Francesca |
author_facet | Flati, Irene Di Vito Nolfi, Mauro Dall’Aglio, Francesca Vecchiotti, Davide Verzella, Daniela Alesse, Edoardo Capece, Daria Zazzeroni, Francesca |
author_sort | Flati, Irene |
collection | PubMed |
description | Metabolism and the immunological state are intimately intertwined, as defense responses are bioenergetically expensive. Metabolic homeostasis is a key requirement for the proper function of immune cell subsets, and the perturbation of the immune–metabolic balance is a recurrent event in many human diseases, including cancer, due to nutrient fluctuation, hypoxia and additional metabolic changes occurring in the tumor microenvironment (TME). Although much remains to be understood in the field of immunometabolism, here, we report the current knowledge on both physiological and cancer-associated metabolic profiles of immune cells, and the main molecular circuits involved in their regulation, highlighting similarities and differences, and emphasizing immune metabolic liabilities that could be exploited in cancer therapy to overcome immune resistance. |
format | Online Article Text |
id | pubmed-10606647 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106066472023-10-28 Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression Flati, Irene Di Vito Nolfi, Mauro Dall’Aglio, Francesca Vecchiotti, Davide Verzella, Daniela Alesse, Edoardo Capece, Daria Zazzeroni, Francesca Genes (Basel) Review Metabolism and the immunological state are intimately intertwined, as defense responses are bioenergetically expensive. Metabolic homeostasis is a key requirement for the proper function of immune cell subsets, and the perturbation of the immune–metabolic balance is a recurrent event in many human diseases, including cancer, due to nutrient fluctuation, hypoxia and additional metabolic changes occurring in the tumor microenvironment (TME). Although much remains to be understood in the field of immunometabolism, here, we report the current knowledge on both physiological and cancer-associated metabolic profiles of immune cells, and the main molecular circuits involved in their regulation, highlighting similarities and differences, and emphasizing immune metabolic liabilities that could be exploited in cancer therapy to overcome immune resistance. MDPI 2023-10-17 /pmc/articles/PMC10606647/ /pubmed/37895302 http://dx.doi.org/10.3390/genes14101953 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Flati, Irene Di Vito Nolfi, Mauro Dall’Aglio, Francesca Vecchiotti, Davide Verzella, Daniela Alesse, Edoardo Capece, Daria Zazzeroni, Francesca Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression |
title | Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression |
title_full | Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression |
title_fullStr | Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression |
title_full_unstemmed | Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression |
title_short | Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression |
title_sort | molecular mechanisms underpinning immunometabolic reprogramming: how the wind changes during cancer progression |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606647/ https://www.ncbi.nlm.nih.gov/pubmed/37895302 http://dx.doi.org/10.3390/genes14101953 |
work_keys_str_mv | AT flatiirene molecularmechanismsunderpinningimmunometabolicreprogramminghowthewindchangesduringcancerprogression AT divitonolfimauro molecularmechanismsunderpinningimmunometabolicreprogramminghowthewindchangesduringcancerprogression AT dallagliofrancesca molecularmechanismsunderpinningimmunometabolicreprogramminghowthewindchangesduringcancerprogression AT vecchiottidavide molecularmechanismsunderpinningimmunometabolicreprogramminghowthewindchangesduringcancerprogression AT verzelladaniela molecularmechanismsunderpinningimmunometabolicreprogramminghowthewindchangesduringcancerprogression AT alesseedoardo molecularmechanismsunderpinningimmunometabolicreprogramminghowthewindchangesduringcancerprogression AT capecedaria molecularmechanismsunderpinningimmunometabolicreprogramminghowthewindchangesduringcancerprogression AT zazzeronifrancesca molecularmechanismsunderpinningimmunometabolicreprogramminghowthewindchangesduringcancerprogression |