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Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression

Metabolism and the immunological state are intimately intertwined, as defense responses are bioenergetically expensive. Metabolic homeostasis is a key requirement for the proper function of immune cell subsets, and the perturbation of the immune–metabolic balance is a recurrent event in many human d...

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Autores principales: Flati, Irene, Di Vito Nolfi, Mauro, Dall’Aglio, Francesca, Vecchiotti, Davide, Verzella, Daniela, Alesse, Edoardo, Capece, Daria, Zazzeroni, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606647/
https://www.ncbi.nlm.nih.gov/pubmed/37895302
http://dx.doi.org/10.3390/genes14101953
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author Flati, Irene
Di Vito Nolfi, Mauro
Dall’Aglio, Francesca
Vecchiotti, Davide
Verzella, Daniela
Alesse, Edoardo
Capece, Daria
Zazzeroni, Francesca
author_facet Flati, Irene
Di Vito Nolfi, Mauro
Dall’Aglio, Francesca
Vecchiotti, Davide
Verzella, Daniela
Alesse, Edoardo
Capece, Daria
Zazzeroni, Francesca
author_sort Flati, Irene
collection PubMed
description Metabolism and the immunological state are intimately intertwined, as defense responses are bioenergetically expensive. Metabolic homeostasis is a key requirement for the proper function of immune cell subsets, and the perturbation of the immune–metabolic balance is a recurrent event in many human diseases, including cancer, due to nutrient fluctuation, hypoxia and additional metabolic changes occurring in the tumor microenvironment (TME). Although much remains to be understood in the field of immunometabolism, here, we report the current knowledge on both physiological and cancer-associated metabolic profiles of immune cells, and the main molecular circuits involved in their regulation, highlighting similarities and differences, and emphasizing immune metabolic liabilities that could be exploited in cancer therapy to overcome immune resistance.
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spelling pubmed-106066472023-10-28 Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression Flati, Irene Di Vito Nolfi, Mauro Dall’Aglio, Francesca Vecchiotti, Davide Verzella, Daniela Alesse, Edoardo Capece, Daria Zazzeroni, Francesca Genes (Basel) Review Metabolism and the immunological state are intimately intertwined, as defense responses are bioenergetically expensive. Metabolic homeostasis is a key requirement for the proper function of immune cell subsets, and the perturbation of the immune–metabolic balance is a recurrent event in many human diseases, including cancer, due to nutrient fluctuation, hypoxia and additional metabolic changes occurring in the tumor microenvironment (TME). Although much remains to be understood in the field of immunometabolism, here, we report the current knowledge on both physiological and cancer-associated metabolic profiles of immune cells, and the main molecular circuits involved in their regulation, highlighting similarities and differences, and emphasizing immune metabolic liabilities that could be exploited in cancer therapy to overcome immune resistance. MDPI 2023-10-17 /pmc/articles/PMC10606647/ /pubmed/37895302 http://dx.doi.org/10.3390/genes14101953 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Flati, Irene
Di Vito Nolfi, Mauro
Dall’Aglio, Francesca
Vecchiotti, Davide
Verzella, Daniela
Alesse, Edoardo
Capece, Daria
Zazzeroni, Francesca
Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression
title Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression
title_full Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression
title_fullStr Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression
title_full_unstemmed Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression
title_short Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression
title_sort molecular mechanisms underpinning immunometabolic reprogramming: how the wind changes during cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606647/
https://www.ncbi.nlm.nih.gov/pubmed/37895302
http://dx.doi.org/10.3390/genes14101953
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