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Stimuli-Responsive Hydrogels for Protein Delivery

Proteins and peptides are potential therapeutic agents, but their physiochemical properties make their use as drug substances challenging. Hydrogels are hydrophilic polymeric networks that can swell and retain high amounts of water or biological fluids without being dissolved. Due to their biocompat...

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Detalles Bibliográficos
Autores principales: Malta, Rafaela, Marques, Ana Camila, da Costa, Paulo Cardoso, Amaral, Maria Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606693/
https://www.ncbi.nlm.nih.gov/pubmed/37888375
http://dx.doi.org/10.3390/gels9100802
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author Malta, Rafaela
Marques, Ana Camila
da Costa, Paulo Cardoso
Amaral, Maria Helena
author_facet Malta, Rafaela
Marques, Ana Camila
da Costa, Paulo Cardoso
Amaral, Maria Helena
author_sort Malta, Rafaela
collection PubMed
description Proteins and peptides are potential therapeutic agents, but their physiochemical properties make their use as drug substances challenging. Hydrogels are hydrophilic polymeric networks that can swell and retain high amounts of water or biological fluids without being dissolved. Due to their biocompatibility, their porous structure, which enables the transport of various peptides and proteins, and their protective effect against degradation, hydrogels have gained prominence as ideal carriers for these molecules’ delivery. Particularly, stimuli-responsive hydrogels exhibit physicochemical transitions in response to subtle modifications in the surrounding environment, leading to the controlled release of entrapped proteins or peptides. This review is focused on the application of these hydrogels in protein and peptide delivery, including a brief overview of therapeutic proteins and types of stimuli-responsive polymers.
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spelling pubmed-106066932023-10-28 Stimuli-Responsive Hydrogels for Protein Delivery Malta, Rafaela Marques, Ana Camila da Costa, Paulo Cardoso Amaral, Maria Helena Gels Review Proteins and peptides are potential therapeutic agents, but their physiochemical properties make their use as drug substances challenging. Hydrogels are hydrophilic polymeric networks that can swell and retain high amounts of water or biological fluids without being dissolved. Due to their biocompatibility, their porous structure, which enables the transport of various peptides and proteins, and their protective effect against degradation, hydrogels have gained prominence as ideal carriers for these molecules’ delivery. Particularly, stimuli-responsive hydrogels exhibit physicochemical transitions in response to subtle modifications in the surrounding environment, leading to the controlled release of entrapped proteins or peptides. This review is focused on the application of these hydrogels in protein and peptide delivery, including a brief overview of therapeutic proteins and types of stimuli-responsive polymers. MDPI 2023-10-06 /pmc/articles/PMC10606693/ /pubmed/37888375 http://dx.doi.org/10.3390/gels9100802 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Malta, Rafaela
Marques, Ana Camila
da Costa, Paulo Cardoso
Amaral, Maria Helena
Stimuli-Responsive Hydrogels for Protein Delivery
title Stimuli-Responsive Hydrogels for Protein Delivery
title_full Stimuli-Responsive Hydrogels for Protein Delivery
title_fullStr Stimuli-Responsive Hydrogels for Protein Delivery
title_full_unstemmed Stimuli-Responsive Hydrogels for Protein Delivery
title_short Stimuli-Responsive Hydrogels for Protein Delivery
title_sort stimuli-responsive hydrogels for protein delivery
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606693/
https://www.ncbi.nlm.nih.gov/pubmed/37888375
http://dx.doi.org/10.3390/gels9100802
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