Cargando…
Stimuli-Responsive Hydrogels for Protein Delivery
Proteins and peptides are potential therapeutic agents, but their physiochemical properties make their use as drug substances challenging. Hydrogels are hydrophilic polymeric networks that can swell and retain high amounts of water or biological fluids without being dissolved. Due to their biocompat...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606693/ https://www.ncbi.nlm.nih.gov/pubmed/37888375 http://dx.doi.org/10.3390/gels9100802 |
_version_ | 1785127376942792704 |
---|---|
author | Malta, Rafaela Marques, Ana Camila da Costa, Paulo Cardoso Amaral, Maria Helena |
author_facet | Malta, Rafaela Marques, Ana Camila da Costa, Paulo Cardoso Amaral, Maria Helena |
author_sort | Malta, Rafaela |
collection | PubMed |
description | Proteins and peptides are potential therapeutic agents, but their physiochemical properties make their use as drug substances challenging. Hydrogels are hydrophilic polymeric networks that can swell and retain high amounts of water or biological fluids without being dissolved. Due to their biocompatibility, their porous structure, which enables the transport of various peptides and proteins, and their protective effect against degradation, hydrogels have gained prominence as ideal carriers for these molecules’ delivery. Particularly, stimuli-responsive hydrogels exhibit physicochemical transitions in response to subtle modifications in the surrounding environment, leading to the controlled release of entrapped proteins or peptides. This review is focused on the application of these hydrogels in protein and peptide delivery, including a brief overview of therapeutic proteins and types of stimuli-responsive polymers. |
format | Online Article Text |
id | pubmed-10606693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106066932023-10-28 Stimuli-Responsive Hydrogels for Protein Delivery Malta, Rafaela Marques, Ana Camila da Costa, Paulo Cardoso Amaral, Maria Helena Gels Review Proteins and peptides are potential therapeutic agents, but their physiochemical properties make their use as drug substances challenging. Hydrogels are hydrophilic polymeric networks that can swell and retain high amounts of water or biological fluids without being dissolved. Due to their biocompatibility, their porous structure, which enables the transport of various peptides and proteins, and their protective effect against degradation, hydrogels have gained prominence as ideal carriers for these molecules’ delivery. Particularly, stimuli-responsive hydrogels exhibit physicochemical transitions in response to subtle modifications in the surrounding environment, leading to the controlled release of entrapped proteins or peptides. This review is focused on the application of these hydrogels in protein and peptide delivery, including a brief overview of therapeutic proteins and types of stimuli-responsive polymers. MDPI 2023-10-06 /pmc/articles/PMC10606693/ /pubmed/37888375 http://dx.doi.org/10.3390/gels9100802 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Malta, Rafaela Marques, Ana Camila da Costa, Paulo Cardoso Amaral, Maria Helena Stimuli-Responsive Hydrogels for Protein Delivery |
title | Stimuli-Responsive Hydrogels for Protein Delivery |
title_full | Stimuli-Responsive Hydrogels for Protein Delivery |
title_fullStr | Stimuli-Responsive Hydrogels for Protein Delivery |
title_full_unstemmed | Stimuli-Responsive Hydrogels for Protein Delivery |
title_short | Stimuli-Responsive Hydrogels for Protein Delivery |
title_sort | stimuli-responsive hydrogels for protein delivery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606693/ https://www.ncbi.nlm.nih.gov/pubmed/37888375 http://dx.doi.org/10.3390/gels9100802 |
work_keys_str_mv | AT maltarafaela stimuliresponsivehydrogelsforproteindelivery AT marquesanacamila stimuliresponsivehydrogelsforproteindelivery AT dacostapaulocardoso stimuliresponsivehydrogelsforproteindelivery AT amaralmariahelena stimuliresponsivehydrogelsforproteindelivery |