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Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration

Increased prevalence of cardiovascular disease and potentially life-threatening complications of myocardial infarction (MI) has led to emerging therapeutic approaches focusing on myocardial regeneration and restoration of physiologic function following infarction. Extracellular vesicle (EV) technolo...

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Autores principales: Ghassemi, Kaitlyn, Inouye, Keiko, Takhmazyan, Tatevik, Bonavida, Victor, Yang, Jia-Wei, de Barros, Natan Roberto, Thankam, Finosh G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606880/
https://www.ncbi.nlm.nih.gov/pubmed/37888397
http://dx.doi.org/10.3390/gels9100824
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author Ghassemi, Kaitlyn
Inouye, Keiko
Takhmazyan, Tatevik
Bonavida, Victor
Yang, Jia-Wei
de Barros, Natan Roberto
Thankam, Finosh G.
author_facet Ghassemi, Kaitlyn
Inouye, Keiko
Takhmazyan, Tatevik
Bonavida, Victor
Yang, Jia-Wei
de Barros, Natan Roberto
Thankam, Finosh G.
author_sort Ghassemi, Kaitlyn
collection PubMed
description Increased prevalence of cardiovascular disease and potentially life-threatening complications of myocardial infarction (MI) has led to emerging therapeutic approaches focusing on myocardial regeneration and restoration of physiologic function following infarction. Extracellular vesicle (EV) technology has gained attention owing to the biological potential to modulate cellular immune responses and promote the repair of damaged tissue. Also, EVs are involved in local and distant cellular communication following damage and play an important role in initiating the repair process. Vesicles derived from stem cells and cardiomyocytes (CM) are of particular interest due to their ability to promote cell growth, proliferation, and angiogenesis following MI. Although a promising candidate for myocardial repair, EV technology is limited by the short retention time of vesicles and rapid elimination by the body. There have been several successful attempts to address this shortcoming, which includes hydrogel technology for the sustained bioavailability of EVs. This review discusses and summarizes current understanding regarding EV technology in the context of myocardial repair.
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spelling pubmed-106068802023-10-28 Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration Ghassemi, Kaitlyn Inouye, Keiko Takhmazyan, Tatevik Bonavida, Victor Yang, Jia-Wei de Barros, Natan Roberto Thankam, Finosh G. Gels Review Increased prevalence of cardiovascular disease and potentially life-threatening complications of myocardial infarction (MI) has led to emerging therapeutic approaches focusing on myocardial regeneration and restoration of physiologic function following infarction. Extracellular vesicle (EV) technology has gained attention owing to the biological potential to modulate cellular immune responses and promote the repair of damaged tissue. Also, EVs are involved in local and distant cellular communication following damage and play an important role in initiating the repair process. Vesicles derived from stem cells and cardiomyocytes (CM) are of particular interest due to their ability to promote cell growth, proliferation, and angiogenesis following MI. Although a promising candidate for myocardial repair, EV technology is limited by the short retention time of vesicles and rapid elimination by the body. There have been several successful attempts to address this shortcoming, which includes hydrogel technology for the sustained bioavailability of EVs. This review discusses and summarizes current understanding regarding EV technology in the context of myocardial repair. MDPI 2023-10-18 /pmc/articles/PMC10606880/ /pubmed/37888397 http://dx.doi.org/10.3390/gels9100824 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ghassemi, Kaitlyn
Inouye, Keiko
Takhmazyan, Tatevik
Bonavida, Victor
Yang, Jia-Wei
de Barros, Natan Roberto
Thankam, Finosh G.
Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration
title Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration
title_full Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration
title_fullStr Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration
title_full_unstemmed Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration
title_short Engineered Vesicles and Hydrogel Technologies for Myocardial Regeneration
title_sort engineered vesicles and hydrogel technologies for myocardial regeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606880/
https://www.ncbi.nlm.nih.gov/pubmed/37888397
http://dx.doi.org/10.3390/gels9100824
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