High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia

The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally i...

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Detalles Bibliográficos
Autores principales: Uricoechea Patiño, Daniel, Collins, Andrew, García, Oscar Julián Romero, Santos Vecino, Gustavo, Cuenca, José Vicente Rodríguez, Bernal, Jaime E., Benavides Benítez, Escilda, Vergara Muñoz, Saray, Briceño Balcázar, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606881/
https://www.ncbi.nlm.nih.gov/pubmed/37895202
http://dx.doi.org/10.3390/genes14101853
Descripción
Sumario:The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia.

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