High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia

The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally i...

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Autores principales: Uricoechea Patiño, Daniel, Collins, Andrew, García, Oscar Julián Romero, Santos Vecino, Gustavo, Cuenca, José Vicente Rodríguez, Bernal, Jaime E., Benavides Benítez, Escilda, Vergara Muñoz, Saray, Briceño Balcázar, Ignacio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606881/
https://www.ncbi.nlm.nih.gov/pubmed/37895202
http://dx.doi.org/10.3390/genes14101853
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author Uricoechea Patiño, Daniel
Collins, Andrew
García, Oscar Julián Romero
Santos Vecino, Gustavo
Cuenca, José Vicente Rodríguez
Bernal, Jaime E.
Benavides Benítez, Escilda
Vergara Muñoz, Saray
Briceño Balcázar, Ignacio
author_facet Uricoechea Patiño, Daniel
Collins, Andrew
García, Oscar Julián Romero
Santos Vecino, Gustavo
Cuenca, José Vicente Rodríguez
Bernal, Jaime E.
Benavides Benítez, Escilda
Vergara Muñoz, Saray
Briceño Balcázar, Ignacio
author_sort Uricoechea Patiño, Daniel
collection PubMed
description The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia.
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spelling pubmed-106068812023-10-28 High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia Uricoechea Patiño, Daniel Collins, Andrew García, Oscar Julián Romero Santos Vecino, Gustavo Cuenca, José Vicente Rodríguez Bernal, Jaime E. Benavides Benítez, Escilda Vergara Muñoz, Saray Briceño Balcázar, Ignacio Genes (Basel) Article The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia. MDPI 2023-09-23 /pmc/articles/PMC10606881/ /pubmed/37895202 http://dx.doi.org/10.3390/genes14101853 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Uricoechea Patiño, Daniel
Collins, Andrew
García, Oscar Julián Romero
Santos Vecino, Gustavo
Cuenca, José Vicente Rodríguez
Bernal, Jaime E.
Benavides Benítez, Escilda
Vergara Muñoz, Saray
Briceño Balcázar, Ignacio
High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia
title High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia
title_full High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia
title_fullStr High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia
title_full_unstemmed High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia
title_short High Mitochondrial Haplotype Diversity Found in Three Pre-Hispanic Groups from Colombia
title_sort high mitochondrial haplotype diversity found in three pre-hispanic groups from colombia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10606881/
https://www.ncbi.nlm.nih.gov/pubmed/37895202
http://dx.doi.org/10.3390/genes14101853
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