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Mortality in Patients with Acute Coronary Syndrome—A Prospective 5-Year Follow-Up Study

Our objective was to compare long-term outcomes in patients with non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) between two time periods in Southern Norway. There are limited contemporary data comparing long-term follow-up after revascularization in th...

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Autores principales: Nguyen, Thuy Mi, Melichova, Daniela, Aabel, Eivind W., Lie, Øyvind H., Klæboe, Lars Gunnar, Grenne, Bjørnar, Sjøli, Benthe, Brunvand, Harald, Haugaa, Kristina, Edvardsen, Thor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607017/
https://www.ncbi.nlm.nih.gov/pubmed/37892735
http://dx.doi.org/10.3390/jcm12206598
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author Nguyen, Thuy Mi
Melichova, Daniela
Aabel, Eivind W.
Lie, Øyvind H.
Klæboe, Lars Gunnar
Grenne, Bjørnar
Sjøli, Benthe
Brunvand, Harald
Haugaa, Kristina
Edvardsen, Thor
author_facet Nguyen, Thuy Mi
Melichova, Daniela
Aabel, Eivind W.
Lie, Øyvind H.
Klæboe, Lars Gunnar
Grenne, Bjørnar
Sjøli, Benthe
Brunvand, Harald
Haugaa, Kristina
Edvardsen, Thor
author_sort Nguyen, Thuy Mi
collection PubMed
description Our objective was to compare long-term outcomes in patients with non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) between two time periods in Southern Norway. There are limited contemporary data comparing long-term follow-up after revascularization in the last decades. This prospective follow-up study consecutively included both NSTEMI and STEMI patients during two time periods, 2014–2015 and 2004–2009. Patients were followed up for a period of 5 years. The primary outcome was all-cause mortality after 1 and 5 years. A total of 539 patients with acute myocardial infarction (AMI), 316 with NSTEMI (234 included in 2014 and 82 included in 2007) and 223 with STEMI (160 included in 2014 and 63 included in 2004). Mortality after NSTEMI was high and remained unchanged during the two time periods (mortality rate at 1 year: 3.5% versus 4.9%, p = 0.50; and 5 years: 11.4% versus 14.6%, p = 0.40). Among STEMI patients, all-cause mortality at 1 year was reduced in 2014 compared to 2004 (1.3% versus 11.1%, p < 0.001; and 5 years: 7.0% versus 22.2%, p = 0.004, respectively). Time to coronary angiography in NSTEMI patients remained unchanged between 2014 and 2007 (28.2 h [IQR 18.1–46.3] versus 30.3 h [IQR 18.0–48.3], p = 0.20), while time to coronary angiography in STEMI patients was improved in 2014 compared with 2004 (2.8 h [IQR 2.0–4.8] versus 21.7 h [IQR 5.4–27.1], p < 0.001), respectively. During one decade of AMI treatment, mortality in patients with NSTEMI remained unchanged while mortality in STEMI patients decreased, both at 1 and 5 years.
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spelling pubmed-106070172023-10-28 Mortality in Patients with Acute Coronary Syndrome—A Prospective 5-Year Follow-Up Study Nguyen, Thuy Mi Melichova, Daniela Aabel, Eivind W. Lie, Øyvind H. Klæboe, Lars Gunnar Grenne, Bjørnar Sjøli, Benthe Brunvand, Harald Haugaa, Kristina Edvardsen, Thor J Clin Med Article Our objective was to compare long-term outcomes in patients with non-ST-elevation myocardial infarction (NSTEMI) and ST-elevation myocardial infarction (STEMI) between two time periods in Southern Norway. There are limited contemporary data comparing long-term follow-up after revascularization in the last decades. This prospective follow-up study consecutively included both NSTEMI and STEMI patients during two time periods, 2014–2015 and 2004–2009. Patients were followed up for a period of 5 years. The primary outcome was all-cause mortality after 1 and 5 years. A total of 539 patients with acute myocardial infarction (AMI), 316 with NSTEMI (234 included in 2014 and 82 included in 2007) and 223 with STEMI (160 included in 2014 and 63 included in 2004). Mortality after NSTEMI was high and remained unchanged during the two time periods (mortality rate at 1 year: 3.5% versus 4.9%, p = 0.50; and 5 years: 11.4% versus 14.6%, p = 0.40). Among STEMI patients, all-cause mortality at 1 year was reduced in 2014 compared to 2004 (1.3% versus 11.1%, p < 0.001; and 5 years: 7.0% versus 22.2%, p = 0.004, respectively). Time to coronary angiography in NSTEMI patients remained unchanged between 2014 and 2007 (28.2 h [IQR 18.1–46.3] versus 30.3 h [IQR 18.0–48.3], p = 0.20), while time to coronary angiography in STEMI patients was improved in 2014 compared with 2004 (2.8 h [IQR 2.0–4.8] versus 21.7 h [IQR 5.4–27.1], p < 0.001), respectively. During one decade of AMI treatment, mortality in patients with NSTEMI remained unchanged while mortality in STEMI patients decreased, both at 1 and 5 years. MDPI 2023-10-18 /pmc/articles/PMC10607017/ /pubmed/37892735 http://dx.doi.org/10.3390/jcm12206598 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nguyen, Thuy Mi
Melichova, Daniela
Aabel, Eivind W.
Lie, Øyvind H.
Klæboe, Lars Gunnar
Grenne, Bjørnar
Sjøli, Benthe
Brunvand, Harald
Haugaa, Kristina
Edvardsen, Thor
Mortality in Patients with Acute Coronary Syndrome—A Prospective 5-Year Follow-Up Study
title Mortality in Patients with Acute Coronary Syndrome—A Prospective 5-Year Follow-Up Study
title_full Mortality in Patients with Acute Coronary Syndrome—A Prospective 5-Year Follow-Up Study
title_fullStr Mortality in Patients with Acute Coronary Syndrome—A Prospective 5-Year Follow-Up Study
title_full_unstemmed Mortality in Patients with Acute Coronary Syndrome—A Prospective 5-Year Follow-Up Study
title_short Mortality in Patients with Acute Coronary Syndrome—A Prospective 5-Year Follow-Up Study
title_sort mortality in patients with acute coronary syndrome—a prospective 5-year follow-up study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607017/
https://www.ncbi.nlm.nih.gov/pubmed/37892735
http://dx.doi.org/10.3390/jcm12206598
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