Computational Investigations on Reaction Mechanisms of the Covalent Inhibitors Ponatinib and Analogs Targeting the Extracellular Signal-Regulated Kinases

As an important cancer therapeutic target, extracellular signal-regulated kinases (ERK) are involved in triggering various cellular responses in tumors. Regulation of the ERK signaling pathway by the small molecular inhibitors is highly desired for the sake of cancer therapy. In contrast to the rout...

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Detalles Bibliográficos
Autores principales: Tian, Yafeng, Zhang, Mi, Heng, Panpan, Hou, Hua, Wang, Baoshan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607051/
https://www.ncbi.nlm.nih.gov/pubmed/37894903
http://dx.doi.org/10.3390/ijms242015223

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607051/
https://www.ncbi.nlm.nih.gov/pubmed/37894903
http://dx.doi.org/10.3390/ijms242015223

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