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Regulatory Elements Outside Established Pou5f1 Gene Boundaries Are Required for Multilineage Differentiation of Embryonic Stem Cells

The transcription factor Oct4 can rightfully be considered a pivotal element in maintaining pluripotency. In addition, its ability to function as a pioneer factor enables the reprogramming of somatic cells back into a pluripotent state. To better understand the regulation of the Oct4-encoding gene (...

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Detalles Bibliográficos
Autores principales: Ermakova, Veronika V., Fokin, Nikita P., Aksenov, Nikolay D., Bakhmet, Evgeny I., Aleksandrova, Ekaterina V., Kuzmin, Andrey A., Tomilin, Alexey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607089/
https://www.ncbi.nlm.nih.gov/pubmed/37895112
http://dx.doi.org/10.3390/ijms242015434