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Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units

Purpose: Recent years have seen a clear link established between elevated ferritin levels and COVID-19 prognosis. However, the impact of heightened ferritin levels on the prognosis of individuals with severe ischemic heart disease remains uncertain. Methods: We utilized the MIMIC IV database to iden...

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Autores principales: Liu, Shun, Chen, Mingxian, Tang, Liang, Li, Xuping, Zhou, Shenghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607098/
https://www.ncbi.nlm.nih.gov/pubmed/37892684
http://dx.doi.org/10.3390/jcm12206547
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author Liu, Shun
Chen, Mingxian
Tang, Liang
Li, Xuping
Zhou, Shenghua
author_facet Liu, Shun
Chen, Mingxian
Tang, Liang
Li, Xuping
Zhou, Shenghua
author_sort Liu, Shun
collection PubMed
description Purpose: Recent years have seen a clear link established between elevated ferritin levels and COVID-19 prognosis. However, the impact of heightened ferritin levels on the prognosis of individuals with severe ischemic heart disease remains uncertain. Methods: We utilized the MIMIC IV database to identify a cohort of ischemic heart disease patients who underwent serum ferritin testing. We conducted regression analyses, employed the overlap propensity score weighting model, and utilized the restricted cubic splines model to comprehensively investigate the associations between serum ferritin levels and clinical outcomes. Results: Our cohort included 1173 patients with diagnosed ischemic heart disease, categorized into high and low serum ferritin groups. After meticulous adjustment for confounding factors in a fully adjusted model, the hazard ratios (HRs) for 90-day and 1-year mortality were 1.63 (95% CI: 1.27–2.09) and 1.49 (95% CI: 1.19–1.86), respectively, in the high-ferritin group compared to the low-ferritin group. Subsequent analyses with propensity score weighting confirmed these results. Remarkably, restricted cubic spline analysis revealed an almost linear relationship between log-transformed serum ferritin levels and the risk of both 90-day and 1-year all-cause mortality. Moreover, incorporating ferritin into conventional severity of illness scores significantly improved the area under the curve for both 90-day and 1-year mortality. Conclusions: This study provides compelling evidence regarding the prognostic significance of serum ferritin in predicting 90-day and one-year mortality rates among patients diagnosed with ischemic heart disease.
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spelling pubmed-106070982023-10-28 Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units Liu, Shun Chen, Mingxian Tang, Liang Li, Xuping Zhou, Shenghua J Clin Med Article Purpose: Recent years have seen a clear link established between elevated ferritin levels and COVID-19 prognosis. However, the impact of heightened ferritin levels on the prognosis of individuals with severe ischemic heart disease remains uncertain. Methods: We utilized the MIMIC IV database to identify a cohort of ischemic heart disease patients who underwent serum ferritin testing. We conducted regression analyses, employed the overlap propensity score weighting model, and utilized the restricted cubic splines model to comprehensively investigate the associations between serum ferritin levels and clinical outcomes. Results: Our cohort included 1173 patients with diagnosed ischemic heart disease, categorized into high and low serum ferritin groups. After meticulous adjustment for confounding factors in a fully adjusted model, the hazard ratios (HRs) for 90-day and 1-year mortality were 1.63 (95% CI: 1.27–2.09) and 1.49 (95% CI: 1.19–1.86), respectively, in the high-ferritin group compared to the low-ferritin group. Subsequent analyses with propensity score weighting confirmed these results. Remarkably, restricted cubic spline analysis revealed an almost linear relationship between log-transformed serum ferritin levels and the risk of both 90-day and 1-year all-cause mortality. Moreover, incorporating ferritin into conventional severity of illness scores significantly improved the area under the curve for both 90-day and 1-year mortality. Conclusions: This study provides compelling evidence regarding the prognostic significance of serum ferritin in predicting 90-day and one-year mortality rates among patients diagnosed with ischemic heart disease. MDPI 2023-10-16 /pmc/articles/PMC10607098/ /pubmed/37892684 http://dx.doi.org/10.3390/jcm12206547 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Shun
Chen, Mingxian
Tang, Liang
Li, Xuping
Zhou, Shenghua
Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units
title Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units
title_full Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units
title_fullStr Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units
title_full_unstemmed Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units
title_short Association between Serum Ferritin and Prognosis in Patients with Ischemic Heart Disease in Intensive Care Units
title_sort association between serum ferritin and prognosis in patients with ischemic heart disease in intensive care units
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607098/
https://www.ncbi.nlm.nih.gov/pubmed/37892684
http://dx.doi.org/10.3390/jcm12206547
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