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Study on Mechanical Properties and Degradation Behavior of Magnesium Alloy Vascular Clip

The Mg alloy vascular clip has biodegradability and good biocompatibility, which can improve the convenience and safety of clinical application. However, the Mg alloy vascular clip also has some disadvantages, such as an unreasonable structure design and a degradation rate which is too fast. In this...

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Autores principales: Zhang, Hongxu, Gao, Ming, Tian, Xiaoying, Cao, Dali, Tan, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607122/
https://www.ncbi.nlm.nih.gov/pubmed/37888166
http://dx.doi.org/10.3390/jfb14100501
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author Zhang, Hongxu
Gao, Ming
Tian, Xiaoying
Cao, Dali
Tan, Lili
author_facet Zhang, Hongxu
Gao, Ming
Tian, Xiaoying
Cao, Dali
Tan, Lili
author_sort Zhang, Hongxu
collection PubMed
description The Mg alloy vascular clip has biodegradability and good biocompatibility, which can improve the convenience and safety of clinical application. However, the Mg alloy vascular clip also has some disadvantages, such as an unreasonable structure design and a degradation rate which is too fast. In this study, the process of clamping blood vessels with a biodegradable Mg alloy (Mg-Zn-Nd-Zr and Mg-Zn-Nd) general V-type vascular clip was simulated by finite element simulation software (Abaqus). A new type of vascular clip, the P-type vascular clip, was analyzed and investigated through simulation. The differences between Mg alloy vascular clips of V-type and P-type were analyzed by finite element simulation. In addition, the effects of Zr element on the mechanical properties and corrosion resistance of P-type vascular clips were also investigated to improve the mechanical stability. The results show that during the V-type vascular clip closure of Mg-Zn-Nd-Zr alloy, this clip has some problems, such as uneven distribution of blood vessel stress, crevices in blood vessels and stress concentration. The improved P-type vascular clip has uniform closure, and there is no gap in the blood vessel, which can effectively avoid stress concentration. The improved P-type vascular clip is well closed and can effectively avoid stress concentration. The corrosion resistance of the Mg-Zn-Nd-Zr alloy P-type clip was better than that of the Mg-Zn-Nd alloy P-type clip (degradation rate of 2.02 mm/y and 2.61 mm/y on the 7th day, respectively). Mg-Zn-Nd-Zr alloy The P-type vascular clip remained closed even on the 7th day, which could meet the requirements of clinical application.
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spelling pubmed-106071222023-10-28 Study on Mechanical Properties and Degradation Behavior of Magnesium Alloy Vascular Clip Zhang, Hongxu Gao, Ming Tian, Xiaoying Cao, Dali Tan, Lili J Funct Biomater Article The Mg alloy vascular clip has biodegradability and good biocompatibility, which can improve the convenience and safety of clinical application. However, the Mg alloy vascular clip also has some disadvantages, such as an unreasonable structure design and a degradation rate which is too fast. In this study, the process of clamping blood vessels with a biodegradable Mg alloy (Mg-Zn-Nd-Zr and Mg-Zn-Nd) general V-type vascular clip was simulated by finite element simulation software (Abaqus). A new type of vascular clip, the P-type vascular clip, was analyzed and investigated through simulation. The differences between Mg alloy vascular clips of V-type and P-type were analyzed by finite element simulation. In addition, the effects of Zr element on the mechanical properties and corrosion resistance of P-type vascular clips were also investigated to improve the mechanical stability. The results show that during the V-type vascular clip closure of Mg-Zn-Nd-Zr alloy, this clip has some problems, such as uneven distribution of blood vessel stress, crevices in blood vessels and stress concentration. The improved P-type vascular clip has uniform closure, and there is no gap in the blood vessel, which can effectively avoid stress concentration. The improved P-type vascular clip is well closed and can effectively avoid stress concentration. The corrosion resistance of the Mg-Zn-Nd-Zr alloy P-type clip was better than that of the Mg-Zn-Nd alloy P-type clip (degradation rate of 2.02 mm/y and 2.61 mm/y on the 7th day, respectively). Mg-Zn-Nd-Zr alloy The P-type vascular clip remained closed even on the 7th day, which could meet the requirements of clinical application. MDPI 2023-10-09 /pmc/articles/PMC10607122/ /pubmed/37888166 http://dx.doi.org/10.3390/jfb14100501 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhang, Hongxu
Gao, Ming
Tian, Xiaoying
Cao, Dali
Tan, Lili
Study on Mechanical Properties and Degradation Behavior of Magnesium Alloy Vascular Clip
title Study on Mechanical Properties and Degradation Behavior of Magnesium Alloy Vascular Clip
title_full Study on Mechanical Properties and Degradation Behavior of Magnesium Alloy Vascular Clip
title_fullStr Study on Mechanical Properties and Degradation Behavior of Magnesium Alloy Vascular Clip
title_full_unstemmed Study on Mechanical Properties and Degradation Behavior of Magnesium Alloy Vascular Clip
title_short Study on Mechanical Properties and Degradation Behavior of Magnesium Alloy Vascular Clip
title_sort study on mechanical properties and degradation behavior of magnesium alloy vascular clip
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607122/
https://www.ncbi.nlm.nih.gov/pubmed/37888166
http://dx.doi.org/10.3390/jfb14100501
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