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Recent Advances in Biomimetic Nanocarrier-Based Photothermal Therapy for Cancer Treatment

Nanomedicine presents innovative solutions for cancer treatment, including photothermal therapy (PTT). PTT centers on the design of photoactivatable nanoparticles capable of absorbing non-toxic near-infrared light, generating heat within target cells to induce cell death. The successful transition f...

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Detalles Bibliográficos
Autores principales: Gallo, Juan, Villasante, Aranzazu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607206/
https://www.ncbi.nlm.nih.gov/pubmed/37895165
http://dx.doi.org/10.3390/ijms242015484
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author Gallo, Juan
Villasante, Aranzazu
author_facet Gallo, Juan
Villasante, Aranzazu
author_sort Gallo, Juan
collection PubMed
description Nanomedicine presents innovative solutions for cancer treatment, including photothermal therapy (PTT). PTT centers on the design of photoactivatable nanoparticles capable of absorbing non-toxic near-infrared light, generating heat within target cells to induce cell death. The successful transition from benchside to bedside application of PTT critically depends on the core properties of nanoparticles responsible for converting light into heat and the surface properties for precise cell-specific targeting. Precisely targeting the intended cells remains a primary challenge in PTT. In recent years, a groundbreaking approach has emerged to address this challenge by functionalizing nanocarriers and enhancing cell targeting. This strategy involves the creation of biomimetic nanoparticles that combine desired biocompatibility properties with the immune evasion mechanisms of natural materials. This review comprehensively outlines various strategies for designing biomimetic photoactivatable nanocarriers for PTT, with a primary focus on its application in cancer therapy. Additionally, we shed light on the hurdles involved in translating PTT from research to clinical practice, along with an overview of current clinical applications.
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spelling pubmed-106072062023-10-28 Recent Advances in Biomimetic Nanocarrier-Based Photothermal Therapy for Cancer Treatment Gallo, Juan Villasante, Aranzazu Int J Mol Sci Review Nanomedicine presents innovative solutions for cancer treatment, including photothermal therapy (PTT). PTT centers on the design of photoactivatable nanoparticles capable of absorbing non-toxic near-infrared light, generating heat within target cells to induce cell death. The successful transition from benchside to bedside application of PTT critically depends on the core properties of nanoparticles responsible for converting light into heat and the surface properties for precise cell-specific targeting. Precisely targeting the intended cells remains a primary challenge in PTT. In recent years, a groundbreaking approach has emerged to address this challenge by functionalizing nanocarriers and enhancing cell targeting. This strategy involves the creation of biomimetic nanoparticles that combine desired biocompatibility properties with the immune evasion mechanisms of natural materials. This review comprehensively outlines various strategies for designing biomimetic photoactivatable nanocarriers for PTT, with a primary focus on its application in cancer therapy. Additionally, we shed light on the hurdles involved in translating PTT from research to clinical practice, along with an overview of current clinical applications. MDPI 2023-10-23 /pmc/articles/PMC10607206/ /pubmed/37895165 http://dx.doi.org/10.3390/ijms242015484 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gallo, Juan
Villasante, Aranzazu
Recent Advances in Biomimetic Nanocarrier-Based Photothermal Therapy for Cancer Treatment
title Recent Advances in Biomimetic Nanocarrier-Based Photothermal Therapy for Cancer Treatment
title_full Recent Advances in Biomimetic Nanocarrier-Based Photothermal Therapy for Cancer Treatment
title_fullStr Recent Advances in Biomimetic Nanocarrier-Based Photothermal Therapy for Cancer Treatment
title_full_unstemmed Recent Advances in Biomimetic Nanocarrier-Based Photothermal Therapy for Cancer Treatment
title_short Recent Advances in Biomimetic Nanocarrier-Based Photothermal Therapy for Cancer Treatment
title_sort recent advances in biomimetic nanocarrier-based photothermal therapy for cancer treatment
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607206/
https://www.ncbi.nlm.nih.gov/pubmed/37895165
http://dx.doi.org/10.3390/ijms242015484
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