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Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior
The transient receptor potential cation channel, subfamily C, member 6 (TRPC6), has been believed to adjust the formation of an excitatory synapse. The positive regulation of TRPC6 engenders synapse enlargement and improved learning and memory in animal models. TRPC6 is involved in different synapto...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607207/ https://www.ncbi.nlm.nih.gov/pubmed/37895105 http://dx.doi.org/10.3390/ijms242015415 |
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author | Zernov, Nikita Popugaeva, Elena |
author_facet | Zernov, Nikita Popugaeva, Elena |
author_sort | Zernov, Nikita |
collection | PubMed |
description | The transient receptor potential cation channel, subfamily C, member 6 (TRPC6), has been believed to adjust the formation of an excitatory synapse. The positive regulation of TRPC6 engenders synapse enlargement and improved learning and memory in animal models. TRPC6 is involved in different synaptoprotective signaling pathways, including antagonism of N-methyl-D-aspartate receptor (NMDAR), activation of brain-derived neurotrophic factor (BDNF) and postsynaptic store-operated calcium entry. Positive regulation of TRPC6 channels has been repeatedly shown to be good for memory formation and storage. TRPC6 is mainly expressed in the hippocampus, particularly in the dentate granule cells, cornu Ammonis 3 (CA3) pyramidal cells and gamma-aminobutyric acid (GABA)ergic interneurons. It has been observed that TRPC6 agonists have a great influence on animal behavior including memory formation and storage The purpose of this review is to collect the available information on the role of TRPC6 in memory formation in various parts of the brain to understand how TRPC6-specific pharmaceutical agents will affect memory in distinct parts of the central nervous system (CNS). |
format | Online Article Text |
id | pubmed-10607207 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106072072023-10-28 Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior Zernov, Nikita Popugaeva, Elena Int J Mol Sci Review The transient receptor potential cation channel, subfamily C, member 6 (TRPC6), has been believed to adjust the formation of an excitatory synapse. The positive regulation of TRPC6 engenders synapse enlargement and improved learning and memory in animal models. TRPC6 is involved in different synaptoprotective signaling pathways, including antagonism of N-methyl-D-aspartate receptor (NMDAR), activation of brain-derived neurotrophic factor (BDNF) and postsynaptic store-operated calcium entry. Positive regulation of TRPC6 channels has been repeatedly shown to be good for memory formation and storage. TRPC6 is mainly expressed in the hippocampus, particularly in the dentate granule cells, cornu Ammonis 3 (CA3) pyramidal cells and gamma-aminobutyric acid (GABA)ergic interneurons. It has been observed that TRPC6 agonists have a great influence on animal behavior including memory formation and storage The purpose of this review is to collect the available information on the role of TRPC6 in memory formation in various parts of the brain to understand how TRPC6-specific pharmaceutical agents will affect memory in distinct parts of the central nervous system (CNS). MDPI 2023-10-21 /pmc/articles/PMC10607207/ /pubmed/37895105 http://dx.doi.org/10.3390/ijms242015415 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zernov, Nikita Popugaeva, Elena Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior |
title | Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior |
title_full | Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior |
title_fullStr | Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior |
title_full_unstemmed | Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior |
title_short | Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior |
title_sort | role of neuronal trpc6 channels in synapse development, memory formation and animal behavior |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607207/ https://www.ncbi.nlm.nih.gov/pubmed/37895105 http://dx.doi.org/10.3390/ijms242015415 |
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