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Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior

The transient receptor potential cation channel, subfamily C, member 6 (TRPC6), has been believed to adjust the formation of an excitatory synapse. The positive regulation of TRPC6 engenders synapse enlargement and improved learning and memory in animal models. TRPC6 is involved in different synapto...

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Detalles Bibliográficos
Autores principales: Zernov, Nikita, Popugaeva, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607207/
https://www.ncbi.nlm.nih.gov/pubmed/37895105
http://dx.doi.org/10.3390/ijms242015415
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author Zernov, Nikita
Popugaeva, Elena
author_facet Zernov, Nikita
Popugaeva, Elena
author_sort Zernov, Nikita
collection PubMed
description The transient receptor potential cation channel, subfamily C, member 6 (TRPC6), has been believed to adjust the formation of an excitatory synapse. The positive regulation of TRPC6 engenders synapse enlargement and improved learning and memory in animal models. TRPC6 is involved in different synaptoprotective signaling pathways, including antagonism of N-methyl-D-aspartate receptor (NMDAR), activation of brain-derived neurotrophic factor (BDNF) and postsynaptic store-operated calcium entry. Positive regulation of TRPC6 channels has been repeatedly shown to be good for memory formation and storage. TRPC6 is mainly expressed in the hippocampus, particularly in the dentate granule cells, cornu Ammonis 3 (CA3) pyramidal cells and gamma-aminobutyric acid (GABA)ergic interneurons. It has been observed that TRPC6 agonists have a great influence on animal behavior including memory formation and storage The purpose of this review is to collect the available information on the role of TRPC6 in memory formation in various parts of the brain to understand how TRPC6-specific pharmaceutical agents will affect memory in distinct parts of the central nervous system (CNS).
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spelling pubmed-106072072023-10-28 Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior Zernov, Nikita Popugaeva, Elena Int J Mol Sci Review The transient receptor potential cation channel, subfamily C, member 6 (TRPC6), has been believed to adjust the formation of an excitatory synapse. The positive regulation of TRPC6 engenders synapse enlargement and improved learning and memory in animal models. TRPC6 is involved in different synaptoprotective signaling pathways, including antagonism of N-methyl-D-aspartate receptor (NMDAR), activation of brain-derived neurotrophic factor (BDNF) and postsynaptic store-operated calcium entry. Positive regulation of TRPC6 channels has been repeatedly shown to be good for memory formation and storage. TRPC6 is mainly expressed in the hippocampus, particularly in the dentate granule cells, cornu Ammonis 3 (CA3) pyramidal cells and gamma-aminobutyric acid (GABA)ergic interneurons. It has been observed that TRPC6 agonists have a great influence on animal behavior including memory formation and storage The purpose of this review is to collect the available information on the role of TRPC6 in memory formation in various parts of the brain to understand how TRPC6-specific pharmaceutical agents will affect memory in distinct parts of the central nervous system (CNS). MDPI 2023-10-21 /pmc/articles/PMC10607207/ /pubmed/37895105 http://dx.doi.org/10.3390/ijms242015415 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zernov, Nikita
Popugaeva, Elena
Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior
title Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior
title_full Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior
title_fullStr Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior
title_full_unstemmed Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior
title_short Role of Neuronal TRPC6 Channels in Synapse Development, Memory Formation and Animal Behavior
title_sort role of neuronal trpc6 channels in synapse development, memory formation and animal behavior
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607207/
https://www.ncbi.nlm.nih.gov/pubmed/37895105
http://dx.doi.org/10.3390/ijms242015415
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