The W101C KCNJ5 Mutation Induces Slower Pacing by Constitutively Active GIRK Channels in hiPSC-Derived Cardiomyocytes

Mutations in the KCNJ5 gene, encoding one of the major subunits of cardiac G-protein-gated inwardly rectifying K(+) (GIRK) channels, have been recently linked to inherited forms of sinus node dysfunction. Here, the pathogenic mechanism of the W101C KCNJ5 mutation underlying sinus bradycardia in a pa...

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Detalles Bibliográficos
Autores principales: Kayser, Anne, Dittmann, Sven, Šarić, Tomo, Mearini, Giulia, Verkerk, Arie O., Schulze-Bahr, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607318/
https://www.ncbi.nlm.nih.gov/pubmed/37894977
http://dx.doi.org/10.3390/ijms242015290

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607318/
https://www.ncbi.nlm.nih.gov/pubmed/37894977
http://dx.doi.org/10.3390/ijms242015290

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