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Effect of Lipids on Diabetic Retinopathy in a Large Cohort of Diabetic Patients after 10 Years of Follow-Up
(1) Background: Diabetic retinopathy (DR) remains the leading cause of low vision and blindness in young adults of working age. Although the most important risk factors—such as the duration of diabetes mellitus (DM) and glycemic control measured by HbA1c—are known, the effects of lipids are not as c...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607322/ https://www.ncbi.nlm.nih.gov/pubmed/37892811 http://dx.doi.org/10.3390/jcm12206674 |
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author | Romero-Aroca, Pedro Verges, Raquel Pascual-Fontanilles, Jordi Valls, Aida Franch, Josep Barrot, Joan Mundet, Xavier La Torre, Alex Moreno, Antonio Sagarra, Ramon Basora, Josep Garcia-Curto, Eugeni Baget-Bernaldiz, Marc |
author_facet | Romero-Aroca, Pedro Verges, Raquel Pascual-Fontanilles, Jordi Valls, Aida Franch, Josep Barrot, Joan Mundet, Xavier La Torre, Alex Moreno, Antonio Sagarra, Ramon Basora, Josep Garcia-Curto, Eugeni Baget-Bernaldiz, Marc |
author_sort | Romero-Aroca, Pedro |
collection | PubMed |
description | (1) Background: Diabetic retinopathy (DR) remains the leading cause of low vision and blindness in young adults of working age. Although the most important risk factors—such as the duration of diabetes mellitus (DM) and glycemic control measured by HbA1c—are known, the effects of lipids are not as clear. The aim of the present study is to analyze the effects of lipids on the development of DR. (2) Methods: This is a retrospective study of a population of 175,645 DM2 patients, during the period 2010 to 2020, in which the effects of different lipid factors are studied. (3) Results: The variables that most influenced the development of DR in our study, based on significance and cumulative hazard (CH), were arterial hypertension (CH 1.217, p < 0.001), HbA1c levels (CH 1.162, p = 0.001), microalbuminuria (CH 1.012, p < 0.001), LDL-C cholesterol (CH 1.007, p = 0.012), TC/HDL-C index (CH 1.092, p < 0.001), No-HDL-C/HDL-C index (CH 1.065, p = 0.002), the use of statins (CH 1.001, p = 0.005), and body mass index (CH 1.007, p < 0.001). (4) Conclusions: LDL-cholesterol, TC/HDL-C, and No-HDL-C/HDL-C indices are related to the development of DR, and there is a protective effect of HDL-cholesterol and the use of fibrates. |
format | Online Article Text |
id | pubmed-10607322 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106073222023-10-28 Effect of Lipids on Diabetic Retinopathy in a Large Cohort of Diabetic Patients after 10 Years of Follow-Up Romero-Aroca, Pedro Verges, Raquel Pascual-Fontanilles, Jordi Valls, Aida Franch, Josep Barrot, Joan Mundet, Xavier La Torre, Alex Moreno, Antonio Sagarra, Ramon Basora, Josep Garcia-Curto, Eugeni Baget-Bernaldiz, Marc J Clin Med Article (1) Background: Diabetic retinopathy (DR) remains the leading cause of low vision and blindness in young adults of working age. Although the most important risk factors—such as the duration of diabetes mellitus (DM) and glycemic control measured by HbA1c—are known, the effects of lipids are not as clear. The aim of the present study is to analyze the effects of lipids on the development of DR. (2) Methods: This is a retrospective study of a population of 175,645 DM2 patients, during the period 2010 to 2020, in which the effects of different lipid factors are studied. (3) Results: The variables that most influenced the development of DR in our study, based on significance and cumulative hazard (CH), were arterial hypertension (CH 1.217, p < 0.001), HbA1c levels (CH 1.162, p = 0.001), microalbuminuria (CH 1.012, p < 0.001), LDL-C cholesterol (CH 1.007, p = 0.012), TC/HDL-C index (CH 1.092, p < 0.001), No-HDL-C/HDL-C index (CH 1.065, p = 0.002), the use of statins (CH 1.001, p = 0.005), and body mass index (CH 1.007, p < 0.001). (4) Conclusions: LDL-cholesterol, TC/HDL-C, and No-HDL-C/HDL-C indices are related to the development of DR, and there is a protective effect of HDL-cholesterol and the use of fibrates. MDPI 2023-10-22 /pmc/articles/PMC10607322/ /pubmed/37892811 http://dx.doi.org/10.3390/jcm12206674 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Romero-Aroca, Pedro Verges, Raquel Pascual-Fontanilles, Jordi Valls, Aida Franch, Josep Barrot, Joan Mundet, Xavier La Torre, Alex Moreno, Antonio Sagarra, Ramon Basora, Josep Garcia-Curto, Eugeni Baget-Bernaldiz, Marc Effect of Lipids on Diabetic Retinopathy in a Large Cohort of Diabetic Patients after 10 Years of Follow-Up |
title | Effect of Lipids on Diabetic Retinopathy in a Large Cohort of Diabetic Patients after 10 Years of Follow-Up |
title_full | Effect of Lipids on Diabetic Retinopathy in a Large Cohort of Diabetic Patients after 10 Years of Follow-Up |
title_fullStr | Effect of Lipids on Diabetic Retinopathy in a Large Cohort of Diabetic Patients after 10 Years of Follow-Up |
title_full_unstemmed | Effect of Lipids on Diabetic Retinopathy in a Large Cohort of Diabetic Patients after 10 Years of Follow-Up |
title_short | Effect of Lipids on Diabetic Retinopathy in a Large Cohort of Diabetic Patients after 10 Years of Follow-Up |
title_sort | effect of lipids on diabetic retinopathy in a large cohort of diabetic patients after 10 years of follow-up |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607322/ https://www.ncbi.nlm.nih.gov/pubmed/37892811 http://dx.doi.org/10.3390/jcm12206674 |
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