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Depression in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis

Polycystic ovary syndrome (PCOS) is an endocrine disorder with a broad spectrum of clinical symptoms. Some of the serious complications of PCOS are mental disorders including depression. Therefore, the aim of the meta-analysis was to determine the prevalence, mean level, standardized mean difference...

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Autores principales: Dybciak, Paweł, Raczkiewicz, Dorota, Humeniuk, Ewa, Powrózek, Tomasz, Gujski, Mariusz, Małecka-Massalska, Teresa, Wdowiak, Artur, Bojar, Iwona
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607337/
https://www.ncbi.nlm.nih.gov/pubmed/37892583
http://dx.doi.org/10.3390/jcm12206446
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author Dybciak, Paweł
Raczkiewicz, Dorota
Humeniuk, Ewa
Powrózek, Tomasz
Gujski, Mariusz
Małecka-Massalska, Teresa
Wdowiak, Artur
Bojar, Iwona
author_facet Dybciak, Paweł
Raczkiewicz, Dorota
Humeniuk, Ewa
Powrózek, Tomasz
Gujski, Mariusz
Małecka-Massalska, Teresa
Wdowiak, Artur
Bojar, Iwona
author_sort Dybciak, Paweł
collection PubMed
description Polycystic ovary syndrome (PCOS) is an endocrine disorder with a broad spectrum of clinical symptoms. Some of the serious complications of PCOS are mental disorders including depression. Therefore, the aim of the meta-analysis was to determine the prevalence, mean level, standardized mean difference and probability of depression based on the research conducted with the Hospital Anxiety and Depression Scale (HADS). A systematic literature search was performed using the following databases: PubMed, EMBASE, Scopus, ClinicalTrials.gov and Google for research published until January 2023. The meta-analysis was conducted on a group of 4002 patients obtained from 19 studies, which met the inclusion criteria (adult pre-menopausal women diagnosed with PCOS, papers on the prevalence of depression or the HADS scoring). According to the research performed, the mean prevalence of depression was 31% (I2 = 93%; p < 0.001), whereas the mean HADS depression score in patients with PCOS was 6.31 (I2 = 93%; p < 0.001). The standardized difference of mean depression scores was SMD = 0.421 (95% confidence interval = 0.17–0.68, I2 = 67%). The overall probability of depression in PCOS patients was more than 2.5-fold higher than in healthy women ((RR: 2.58), confidence interval [1.38–4.85]; I2 = 90%, p < 0.001). The research results imply an increased risk of depressive symptoms in women with PCOS.
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spelling pubmed-106073372023-10-28 Depression in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis Dybciak, Paweł Raczkiewicz, Dorota Humeniuk, Ewa Powrózek, Tomasz Gujski, Mariusz Małecka-Massalska, Teresa Wdowiak, Artur Bojar, Iwona J Clin Med Systematic Review Polycystic ovary syndrome (PCOS) is an endocrine disorder with a broad spectrum of clinical symptoms. Some of the serious complications of PCOS are mental disorders including depression. Therefore, the aim of the meta-analysis was to determine the prevalence, mean level, standardized mean difference and probability of depression based on the research conducted with the Hospital Anxiety and Depression Scale (HADS). A systematic literature search was performed using the following databases: PubMed, EMBASE, Scopus, ClinicalTrials.gov and Google for research published until January 2023. The meta-analysis was conducted on a group of 4002 patients obtained from 19 studies, which met the inclusion criteria (adult pre-menopausal women diagnosed with PCOS, papers on the prevalence of depression or the HADS scoring). According to the research performed, the mean prevalence of depression was 31% (I2 = 93%; p < 0.001), whereas the mean HADS depression score in patients with PCOS was 6.31 (I2 = 93%; p < 0.001). The standardized difference of mean depression scores was SMD = 0.421 (95% confidence interval = 0.17–0.68, I2 = 67%). The overall probability of depression in PCOS patients was more than 2.5-fold higher than in healthy women ((RR: 2.58), confidence interval [1.38–4.85]; I2 = 90%, p < 0.001). The research results imply an increased risk of depressive symptoms in women with PCOS. MDPI 2023-10-10 /pmc/articles/PMC10607337/ /pubmed/37892583 http://dx.doi.org/10.3390/jcm12206446 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Dybciak, Paweł
Raczkiewicz, Dorota
Humeniuk, Ewa
Powrózek, Tomasz
Gujski, Mariusz
Małecka-Massalska, Teresa
Wdowiak, Artur
Bojar, Iwona
Depression in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
title Depression in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
title_full Depression in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
title_fullStr Depression in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
title_full_unstemmed Depression in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
title_short Depression in Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis
title_sort depression in polycystic ovary syndrome: a systematic review and meta-analysis
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607337/
https://www.ncbi.nlm.nih.gov/pubmed/37892583
http://dx.doi.org/10.3390/jcm12206446
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