Cargando…

Suppressors of lapC Mutation Identify New Regulators of LpxC, Which Mediates the First Committed Step in Lipopolysaccharide Biosynthesis

Gram-negative bacteria, such as Escherichia coli, are characterized by an asymmetric outer membrane (OM) with lipopolysaccharide (LPS) located in the outer leaflet and phospholipids facing the inner leaflet. E. coli recruits LPS assembly proteins LapB, LapC and LapD in concert with FtsH protease to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maniyeri, Akshay, Wieczorek, Alicja, Ayyolath, Aravind, Sugalska, Weronika, Klein, Gracjana, Raina, Satish
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607373/ https://www.ncbi.nlm.nih.gov/pubmed/37894855 http://dx.doi.org/10.3390/ijms242015174

Ejemplares similares

A New Factor LapD Is Required for the Regulation of LpxC Amounts and Lipopolysaccharide Trafficking
por: Wieczorek, Alicja, et al.
Publicado: (2022)

Regulation of the First Committed Step in Lipopolysaccharide Biosynthesis Catalyzed by LpxC Requires the Essential Protein LapC (YejM) and HslVU Protease
por: Biernacka, Daria, et al.
Publicado: (2020)

The nucleotide-binding site of Aquifex aeolicus LpxC
por: Buetow, Lori, et al.
Publicado: (2006)

Interplay of Klebsiella pneumoniae fabZ and lpxC Mutations Leads to LpxC Inhibitor-Dependent Growth Resulting from Loss of Membrane Homeostasis
por: Mostafavi, Mina, et al.
Publicado: (2018)

An Essential Membrane Protein Modulates the Proteolysis of LpxC to Control Lipopolysaccharide Synthesis in Escherichia coli
por: Fivenson, Elayne M., et al.
Publicado: (2020)

Regulated Expression of lpxC Allows for Reduction of Endotoxicity in Bordetella pertussis
por: Pérez-Ortega, Jesús, et al.
Publicado: (2022)

Molecular Basis of Essentiality of Early Critical Steps in the Lipopolysaccharide Biogenesis in Escherichia coli K-12: Requirement of MsbA, Cardiolipin, LpxL, LpxM and GcvB
por: Gorzelak, Patrycja, et al.
Publicado: (2021)

Intricate Crosstalk Between Lipopolysaccharide, Phospholipid and Fatty Acid Metabolism in Escherichia coli Modulates Proteolysis of LpxC
por: Thomanek, Nikolas, et al.
Publicado: (2019)

Machine learning approaches to study the structure-activity relationships of LpxC inhibitors
por: Yu, Tianshi, et al.
Publicado: (2023)

Chlamydia spp. development is differentially altered by treatment with the LpxC inhibitor LPC-011
por: Cram, Erik D., et al.
Publicado: (2017)

Inhibition of LpxC Protects Mice from Resistant Acinetobacter baumannii by Modulating Inflammation and Enhancing Phagocytosis
por: Lin, Lin, et al.
Publicado: (2012)

3D-QSAR, Molecular Docking and Molecular Dynamics Simulation of Pseudomonas aeruginosa LpxC Inhibitors
por: Zuo, Ke, et al.
Publicado: (2017)

Inhibition of LpxC Increases the Activity of Iron Chelators and Gallium Nitrate in Multidrug-Resistant Acinetobacter baumannii
por: Vinuesa, Víctor, et al.
Publicado: (2021)

Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC
por: Lemaître, Nadine, et al.
Publicado: (2017)

Application of LpxC enzyme inhibitor to inhibit some fast-growing bacteria in human gut bacterial culturomics
por: Hou, Fengyi, et al.
Publicado: (2019)

LpxC Inhibitors as New Antibacterial Agents and Tools for Studying Regulation of Lipid A Biosynthesis in Gram-Negative Pathogens
por: Tomaras, Andrew P., et al.
Publicado: (2014)

Checkpoints That Regulate Balanced Biosynthesis of Lipopolysaccharide and Its Essentiality in Escherichia coli
por: Klein, Gracjana, et al.
Publicado: (2021)

Application of mouse model for evaluation of recombinant LpxC and GmhA as novel antigenic vaccine candidates of Glaesserella parasuis serotype 13
por: JIA, Yong C., et al.
Publicado: (2021)

TP0586532, a non-hydroxamate LpxC inhibitor, reduces LPS release and IL-6 production both in vitro and in vivo
por: Fujita, Kiyoko, et al.
Publicado: (2022)

lpxC and yafS are the Most Suitable Internal Controls to Normalize Real Time RT-qPCR Expression in the Phytopathogenic Bacteria Dickeya dadantii
por: Hommais, Florence, et al.
Publicado: (2011)

TP0586532, a Novel Non-Hydroxamate LpxC Inhibitor: Potentiating Effect on In Vitro Activity of Meropenem against Carbapenem-Resistant Enterobacteriaceae
por: Yoshida, Ippei, et al.
Publicado: (2022)

Regulated Control of the Assembly and Diversity of LPS by Noncoding sRNAs
por: Klein, Gracjana, et al.
Publicado: (2015)

Small regulatory bacterial RNAs regulating the envelope stress response
por: Klein, Gracjana, et al.
Publicado: (2017)

Regulated Assembly of LPS, Its Structural Alterations and Cellular Response to LPS Defects
por: Klein, Gracjana, et al.
Publicado: (2019)

Identification of lptA, lpxE, and lpxO, Three Genes Involved in the Remodeling of Brucella Cell Envelope
por: Conde-Álvarez, Raquel, et al.
Publicado: (2018)

The Possible Role of Staphylococcus epidermidis LPxTG Surface Protein SesC in Biofilm Formation
por: Khodaparast, Laleh, et al.
Publicado: (2016)

Ablative Radiotherapy (ART) for Locally Advanced Pancreatic Cancer (LAPC): Toward a New Paradigm?
por: Simoni, Nicola, et al.
Publicado: (2022)

Discovery of dual-activity small-molecule ligands of Pseudomonas aeruginosa LpxA and LpxD using SPR and X-ray crystallography
por: Kroeck, Kyle G., et al.
Publicado: (2019)

Combined loss of LAP1B and LAP1C results in an early onset multisystemic nuclear envelopathy
por: Fichtman, Boris, et al.
Publicado: (2019)

Homologs of the LapD-LapG c-di-GMP Effector System Control Biofilm Formation by Bordetella bronchiseptica
por: Ambrosis, Nicolás, et al.
Publicado: (2016)

Lipopolysaccharides: Regulated Biosynthesis and Structural Diversity
por: Raina, Satish
Publicado: (2023)

Efficacy and feasibility of stereotactic radiotherapy after folfirinox in patients with locally advanced pancreatic cancer (LAPC-1 trial)
por: Suker, Mustafa, et al.
Publicado: (2019)

Reliability, Validity, and Responsiveness of the Chinese Learning Accomplishment Profile (C-LAP)
por: Chen, Deng, et al.
Publicado: (2021)

LAPCs promote follicular helper T cell differentiation of Ag-primed CD4(+) T cells during respiratory virus infection
por: Yoo, Jae-Kwang, et al.
Publicado: (2012)

Dose escalation with an IMRT technique in 15 to 28 fractions is better tolerated than standard doses of 3DCRT for LAPC
por: Colbert, Lauren E., et al.
Publicado: (2017)

Prediction of the Closed Conformation and Insights into the Mechanism of the Membrane Enzyme LpxR
por: Saunders, Graham M., et al.
Publicado: (2018)

The final lap…
por: Manohar, Balaji
Publicado: (2013)

Lap-Robotics
Publicado: (2015)

Rigid and Flexible Double Shear Lap Adhesive Joint at Elevated Temperature—An Experimental Study
por: Śliwa-Wieczorek, Klaudia, et al.
Publicado: (2021)

PD-1 blockade plus chemoradiotherapy as preoperative therapy for patients with BRPC/LAPC: A biomolecular exploratory, phase II trial
por: Du, Juan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kin445va1fjiplcm5qd4fhk08p