Cargando…
Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation
Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulation, and one of the key regulatory mechanisms invol...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607381/ https://www.ncbi.nlm.nih.gov/pubmed/37894842 http://dx.doi.org/10.3390/ijms242015162 |
_version_ | 1785127533074710528 |
---|---|
author | Vydra Bousova, Kristyna Zouharova, Monika Jiraskova, Katerina Vetyskova, Veronika |
author_facet | Vydra Bousova, Kristyna Zouharova, Monika Jiraskova, Katerina Vetyskova, Veronika |
author_sort | Vydra Bousova, Kristyna |
collection | PubMed |
description | Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulation, and one of the key regulatory mechanisms involves their interaction with calmodulin (CaM), a cytosol ubiquitous calcium-binding protein. The association between TRPM channels and CaM relies on the presence of specific CaM-binding domains in the channel structure. Upon CaM binding, the channel undergoes direct and/or allosteric structural changes and triggers down- or up-stream signaling pathways. According to current knowledge, ion channel members TRPM2, TRPM3, TRPM4, and TRPM6 are directly modulated by CaM, resulting in their activation or inhibition. This review specifically focuses on the interplay between TRPM channels and CaM and summarizes the current known effects of CaM interactions and modulations on TRPM channels in cellular physiology. |
format | Online Article Text |
id | pubmed-10607381 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106073812023-10-28 Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation Vydra Bousova, Kristyna Zouharova, Monika Jiraskova, Katerina Vetyskova, Veronika Int J Mol Sci Review Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulation, and one of the key regulatory mechanisms involves their interaction with calmodulin (CaM), a cytosol ubiquitous calcium-binding protein. The association between TRPM channels and CaM relies on the presence of specific CaM-binding domains in the channel structure. Upon CaM binding, the channel undergoes direct and/or allosteric structural changes and triggers down- or up-stream signaling pathways. According to current knowledge, ion channel members TRPM2, TRPM3, TRPM4, and TRPM6 are directly modulated by CaM, resulting in their activation or inhibition. This review specifically focuses on the interplay between TRPM channels and CaM and summarizes the current known effects of CaM interactions and modulations on TRPM channels in cellular physiology. MDPI 2023-10-13 /pmc/articles/PMC10607381/ /pubmed/37894842 http://dx.doi.org/10.3390/ijms242015162 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Vydra Bousova, Kristyna Zouharova, Monika Jiraskova, Katerina Vetyskova, Veronika Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation |
title | Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation |
title_full | Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation |
title_fullStr | Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation |
title_full_unstemmed | Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation |
title_short | Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation |
title_sort | interaction of calmodulin with trpm: an initiator of channel modulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607381/ https://www.ncbi.nlm.nih.gov/pubmed/37894842 http://dx.doi.org/10.3390/ijms242015162 |
work_keys_str_mv | AT vydrabousovakristyna interactionofcalmodulinwithtrpmaninitiatorofchannelmodulation AT zouharovamonika interactionofcalmodulinwithtrpmaninitiatorofchannelmodulation AT jiraskovakaterina interactionofcalmodulinwithtrpmaninitiatorofchannelmodulation AT vetyskovaveronika interactionofcalmodulinwithtrpmaninitiatorofchannelmodulation |