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Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation

Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulation, and one of the key regulatory mechanisms invol...

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Autores principales: Vydra Bousova, Kristyna, Zouharova, Monika, Jiraskova, Katerina, Vetyskova, Veronika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607381/
https://www.ncbi.nlm.nih.gov/pubmed/37894842
http://dx.doi.org/10.3390/ijms242015162
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author Vydra Bousova, Kristyna
Zouharova, Monika
Jiraskova, Katerina
Vetyskova, Veronika
author_facet Vydra Bousova, Kristyna
Zouharova, Monika
Jiraskova, Katerina
Vetyskova, Veronika
author_sort Vydra Bousova, Kristyna
collection PubMed
description Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulation, and one of the key regulatory mechanisms involves their interaction with calmodulin (CaM), a cytosol ubiquitous calcium-binding protein. The association between TRPM channels and CaM relies on the presence of specific CaM-binding domains in the channel structure. Upon CaM binding, the channel undergoes direct and/or allosteric structural changes and triggers down- or up-stream signaling pathways. According to current knowledge, ion channel members TRPM2, TRPM3, TRPM4, and TRPM6 are directly modulated by CaM, resulting in their activation or inhibition. This review specifically focuses on the interplay between TRPM channels and CaM and summarizes the current known effects of CaM interactions and modulations on TRPM channels in cellular physiology.
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spelling pubmed-106073812023-10-28 Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation Vydra Bousova, Kristyna Zouharova, Monika Jiraskova, Katerina Vetyskova, Veronika Int J Mol Sci Review Transient receptor potential melastatin (TRPM) channels, a subfamily of the TRP superfamily, constitute a diverse group of ion channels involved in mediating crucial cellular processes like calcium homeostasis. These channels exhibit complex regulation, and one of the key regulatory mechanisms involves their interaction with calmodulin (CaM), a cytosol ubiquitous calcium-binding protein. The association between TRPM channels and CaM relies on the presence of specific CaM-binding domains in the channel structure. Upon CaM binding, the channel undergoes direct and/or allosteric structural changes and triggers down- or up-stream signaling pathways. According to current knowledge, ion channel members TRPM2, TRPM3, TRPM4, and TRPM6 are directly modulated by CaM, resulting in their activation or inhibition. This review specifically focuses on the interplay between TRPM channels and CaM and summarizes the current known effects of CaM interactions and modulations on TRPM channels in cellular physiology. MDPI 2023-10-13 /pmc/articles/PMC10607381/ /pubmed/37894842 http://dx.doi.org/10.3390/ijms242015162 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Vydra Bousova, Kristyna
Zouharova, Monika
Jiraskova, Katerina
Vetyskova, Veronika
Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation
title Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation
title_full Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation
title_fullStr Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation
title_full_unstemmed Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation
title_short Interaction of Calmodulin with TRPM: An Initiator of Channel Modulation
title_sort interaction of calmodulin with trpm: an initiator of channel modulation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607381/
https://www.ncbi.nlm.nih.gov/pubmed/37894842
http://dx.doi.org/10.3390/ijms242015162
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