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Knee Cartilage Lesion Management—Current Trends in Clinical Practice
Many patients, particularly those aged above 40, experience knee joint pain, which hampers both sports activities and daily living. Treating isolated chondral and osteochondral defects in the knee poses a significant clinical challenge, particularly in younger patients who are not typically recommen...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607427/ https://www.ncbi.nlm.nih.gov/pubmed/37892577 http://dx.doi.org/10.3390/jcm12206434 |
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author | Jarecki, Jaromir Waśko, Marcin Krzysztof Widuchowski, Wojciech Tomczyk-Warunek, Agnieszka Wójciak, Magdalena Sowa, Ireneusz Blicharski, Tomasz |
author_facet | Jarecki, Jaromir Waśko, Marcin Krzysztof Widuchowski, Wojciech Tomczyk-Warunek, Agnieszka Wójciak, Magdalena Sowa, Ireneusz Blicharski, Tomasz |
author_sort | Jarecki, Jaromir |
collection | PubMed |
description | Many patients, particularly those aged above 40, experience knee joint pain, which hampers both sports activities and daily living. Treating isolated chondral and osteochondral defects in the knee poses a significant clinical challenge, particularly in younger patients who are not typically recommended partial or total knee arthroplasty as alternatives. Several surgical approaches have been developed to address focal cartilage defects. The treatment strategies are characterized as palliation (e.g., chondroplasty and debridement), repair (e.g., drilling and microfracture), or restoration (e.g., autologous chondrocyte implantation, osteochondral autograft, and osteochondral allograft). This review offers an overview of the commonly employed clinical methods for treating articular cartilage defects, with a specific focus on the clinical trials conducted in the last decade. Our study reveals that, currently, no single technology fully meets the essential requirements for effective cartilage healing while remaining easily applicable during surgical procedures. Nevertheless, numerous methods are available, and the choice of treatment should consider factors such as the location and size of the cartilage lesion, patient preferences, and whether it is chondral or osteochondral in nature. Promising directions for the future include tissue engineering, stem cell therapies, and the development of pre-formed scaffolds from hyaline cartilage, offering hope for improved outcomes. |
format | Online Article Text |
id | pubmed-10607427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106074272023-10-28 Knee Cartilage Lesion Management—Current Trends in Clinical Practice Jarecki, Jaromir Waśko, Marcin Krzysztof Widuchowski, Wojciech Tomczyk-Warunek, Agnieszka Wójciak, Magdalena Sowa, Ireneusz Blicharski, Tomasz J Clin Med Review Many patients, particularly those aged above 40, experience knee joint pain, which hampers both sports activities and daily living. Treating isolated chondral and osteochondral defects in the knee poses a significant clinical challenge, particularly in younger patients who are not typically recommended partial or total knee arthroplasty as alternatives. Several surgical approaches have been developed to address focal cartilage defects. The treatment strategies are characterized as palliation (e.g., chondroplasty and debridement), repair (e.g., drilling and microfracture), or restoration (e.g., autologous chondrocyte implantation, osteochondral autograft, and osteochondral allograft). This review offers an overview of the commonly employed clinical methods for treating articular cartilage defects, with a specific focus on the clinical trials conducted in the last decade. Our study reveals that, currently, no single technology fully meets the essential requirements for effective cartilage healing while remaining easily applicable during surgical procedures. Nevertheless, numerous methods are available, and the choice of treatment should consider factors such as the location and size of the cartilage lesion, patient preferences, and whether it is chondral or osteochondral in nature. Promising directions for the future include tissue engineering, stem cell therapies, and the development of pre-formed scaffolds from hyaline cartilage, offering hope for improved outcomes. MDPI 2023-10-10 /pmc/articles/PMC10607427/ /pubmed/37892577 http://dx.doi.org/10.3390/jcm12206434 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Jarecki, Jaromir Waśko, Marcin Krzysztof Widuchowski, Wojciech Tomczyk-Warunek, Agnieszka Wójciak, Magdalena Sowa, Ireneusz Blicharski, Tomasz Knee Cartilage Lesion Management—Current Trends in Clinical Practice |
title | Knee Cartilage Lesion Management—Current Trends in Clinical Practice |
title_full | Knee Cartilage Lesion Management—Current Trends in Clinical Practice |
title_fullStr | Knee Cartilage Lesion Management—Current Trends in Clinical Practice |
title_full_unstemmed | Knee Cartilage Lesion Management—Current Trends in Clinical Practice |
title_short | Knee Cartilage Lesion Management—Current Trends in Clinical Practice |
title_sort | knee cartilage lesion management—current trends in clinical practice |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607427/ https://www.ncbi.nlm.nih.gov/pubmed/37892577 http://dx.doi.org/10.3390/jcm12206434 |
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