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The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy

Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease. Recently, several retinal layers in PSP compared to healthy controls. were found to be thinner. However, no studies evaluating the correlation between retinal layers and cerebral white matter changes, nor eventual choroidal ch...

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Autores principales: De Bernardo, Maddalena, Diana, Francesco, Gioia, Marco, De Luca, Martina, Tepedino, Maria Francesca, Pellecchia, Maria Teresa, Rosa, Nicola, Barone, Paolo, Picillo, Marina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607459/
https://www.ncbi.nlm.nih.gov/pubmed/37892809
http://dx.doi.org/10.3390/jcm12206671
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author De Bernardo, Maddalena
Diana, Francesco
Gioia, Marco
De Luca, Martina
Tepedino, Maria Francesca
Pellecchia, Maria Teresa
Rosa, Nicola
Barone, Paolo
Picillo, Marina
author_facet De Bernardo, Maddalena
Diana, Francesco
Gioia, Marco
De Luca, Martina
Tepedino, Maria Francesca
Pellecchia, Maria Teresa
Rosa, Nicola
Barone, Paolo
Picillo, Marina
author_sort De Bernardo, Maddalena
collection PubMed
description Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease. Recently, several retinal layers in PSP compared to healthy controls. were found to be thinner. However, no studies evaluating the correlation between retinal layers and cerebral white matter changes, nor eventual choroidal changes in PSP, have been conducted so far. The goals of the present study were to explore potential differences in choroidal structure between PSP and healthy controls, and to describe the relationship between retinal layers’ thickness and volume, using spectral-domain optical coherence tomography (SD-OCT) and age-related white matter change scores (ARWMC) using magnetic resonance imaging (MRI) of the brain. Choroidal structures of 26 PSP patients and 26 healthy controls using standard SD-OCT with an enhanced depth imaging (EDI) approach were analyzed; then, retinal the structures of 16 of these PSP patients using standard SD-OCT were examined; finally, the same patients underwent brain MRI, and their cerebral white matter changes were calculated. Non-statistically significant differences between PSP patients’ and healthy controls’ choroidal structure were found. On the contrary, PSP patients’ inner retinal layers (INR), retinal pigmented epithelium (RPE) and all retinal layers’ thicknesses in the macular region were found to be significantly correlated with ARWMC, independently from age and axial length (AL). PSP patients’ neurological alterations go hand in hand with retinal ones, independently from age and axial length. Our results suggest a mutual relationship between cerebral and retinal structure pathological alterations. On the other hand, no significant differences in the choroidal evaluation compared to healthy controls have been found.
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spelling pubmed-106074592023-10-28 The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy De Bernardo, Maddalena Diana, Francesco Gioia, Marco De Luca, Martina Tepedino, Maria Francesca Pellecchia, Maria Teresa Rosa, Nicola Barone, Paolo Picillo, Marina J Clin Med Article Progressive supranuclear palsy (PSP) is a rare neurodegenerative disease. Recently, several retinal layers in PSP compared to healthy controls. were found to be thinner. However, no studies evaluating the correlation between retinal layers and cerebral white matter changes, nor eventual choroidal changes in PSP, have been conducted so far. The goals of the present study were to explore potential differences in choroidal structure between PSP and healthy controls, and to describe the relationship between retinal layers’ thickness and volume, using spectral-domain optical coherence tomography (SD-OCT) and age-related white matter change scores (ARWMC) using magnetic resonance imaging (MRI) of the brain. Choroidal structures of 26 PSP patients and 26 healthy controls using standard SD-OCT with an enhanced depth imaging (EDI) approach were analyzed; then, retinal the structures of 16 of these PSP patients using standard SD-OCT were examined; finally, the same patients underwent brain MRI, and their cerebral white matter changes were calculated. Non-statistically significant differences between PSP patients’ and healthy controls’ choroidal structure were found. On the contrary, PSP patients’ inner retinal layers (INR), retinal pigmented epithelium (RPE) and all retinal layers’ thicknesses in the macular region were found to be significantly correlated with ARWMC, independently from age and axial length (AL). PSP patients’ neurological alterations go hand in hand with retinal ones, independently from age and axial length. Our results suggest a mutual relationship between cerebral and retinal structure pathological alterations. On the other hand, no significant differences in the choroidal evaluation compared to healthy controls have been found. MDPI 2023-10-22 /pmc/articles/PMC10607459/ /pubmed/37892809 http://dx.doi.org/10.3390/jcm12206671 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
De Bernardo, Maddalena
Diana, Francesco
Gioia, Marco
De Luca, Martina
Tepedino, Maria Francesca
Pellecchia, Maria Teresa
Rosa, Nicola
Barone, Paolo
Picillo, Marina
The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy
title The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy
title_full The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy
title_fullStr The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy
title_full_unstemmed The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy
title_short The Correlation between Retinal and Choroidal Thickness with Age-Related White Matter Hyperintensities in Progressive Supranuclear Palsy
title_sort correlation between retinal and choroidal thickness with age-related white matter hyperintensities in progressive supranuclear palsy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607459/
https://www.ncbi.nlm.nih.gov/pubmed/37892809
http://dx.doi.org/10.3390/jcm12206671
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