Cargando…

Synthesis, Cytotoxic Activity and In Silico Study of Novel Dihydropyridine Carboxylic Acids Derivatives

To aid the possible prevention of multidrug resistance in tumors and cause lower toxicity, a set of sixteen novel dihydropyridine carboxylic acids derivatives 3a–p were produced; thus, the activation of various ynones with triflic anhydride was performed, involving a nucleophilic addition of several...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ballinas-Indilí, Ricardo, Nicolás-Vázquez, María Inés, Martínez, Joel, Ramírez-Apan, María Teresa, Álvarez-Toledano, Cecilio, Toscano, Alfredo, Hernández-Rodríguez, Maricarmen, Mera Jiménez, Elvia, Miranda Ruvalcaba, René
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607468/ https://www.ncbi.nlm.nih.gov/pubmed/37895094 http://dx.doi.org/10.3390/ijms242015414

Ejemplares similares

Drug Repurposing to Inhibit Histamine N-Methyl Transferase
por: Jiménez, Elvia Mera, et al.
Publicado: (2023)

Computational Studies of Aflatoxin B(1) (AFB(1)): A Review
por: Martínez, Joel, et al.
Publicado: (2023)

New Development of Membrane Base Optoelectronic Devices
por: Hamui, Leon, et al.
Publicado: (2017)

In silico Study of the Pharmacologic Properties and Cytotoxicity Pathways in Cancer Cells of Various Indolylquinone Analogues of Perezone
por: Escobedo-González, René, et al.
Publicado: (2017)

Synthesis, Molecular Docking, and Antimycotic Evaluation of Some 3-Acyl Imidazo[1,2-a]pyrimidines
por: Gómez-García, Omar, et al.
Publicado: (2018)

In Silico Study of Novel Cyclodextrin Inclusion Complexes of Polycaprolactone and Its Correlation with Skin Regeneration
por: Escobedo-González, René Gerardo, et al.
Publicado: (2023)

Inhibition of Astrocytic Histamine N-Methyltransferase as a Possible Target for the Treatment of Alzheimer’s Disease
por: Flores-Clemente, Cecilia, et al.
Publicado: (2021)

In Vitro and Computational Studies of Perezone and Perezone Angelate as Potential Anti-Glioblastoma Multiforme Agents
por: Hernández-Rodríguez, Maricarmen, et al.
Publicado: (2022)

Direct Aminolysis of Ethoxycarbonylmethyl 1,4-Dihydropyridine-3-carboxylates
por: Vigante, Brigita, et al.
Publicado: (2015)

Three-Component Synthesis of 2-Amino-3-cyano-4H-chromenes, In Silico Analysis of Their Pharmacological Profile, and In Vitro Anticancer and Antifungal Testing
por: Feliciano, Alberto, et al.
Publicado: (2021)

An isoxazole strategy for the synthesis of 4-oxo-1,4-dihydropyridine-3-carboxylates
por: Zanakhov, Timur O, et al.
Publicado: (2022)

Ethyl 4-oxo-1,4-dihydropyridine-3-carboxylate
por: Gao, Jun, et al.
Publicado: (2021)

The Ability of Chlorophyll to Trap Carcinogen Aflatoxin B(1): A Theoretical Approach
por: Vázquez-Durán, Alma, et al.
Publicado: (2022)

Cytotoxic Effect of Some 1, 4-Dihydropyridine Derivatives Containing Nitroimidazole Moiety
por: Miri, Ramin, et al.
Publicado: (2011)

2-Amino-5-methylpyridinium 6-oxo-1,6-dihydropyridine-2-carboxylate
por: Thanigaimani, Kaliyaperumal, et al.
Publicado: (2012)

Antimicrobial, anticoagulant, and cytotoxic evaluation of multidrug resistance of new 1,4-dihydropyridine derivatives
por: Ahamed, Anis, et al.
Publicado: (2018)

Data for the cytotoxicity, self-assembling properties and synthesis of 4-pyridinium-1,4-dihydropyridines
por: Pajuste, Klavs, et al.
Publicado: (2020)

Virtual and In Vitro Screens Reveal a Potential Pharmacophore that Avoids the Fibrillization of Aβ(1–42)
por: Hernández-Rodríguez, Maricarmen, et al.
Publicado: (2015)

2-Amino-5-bromopyridinium 6-oxo-1,6-dihydropyridine-2-carboxylate monohydrate
por: Hemamalini, Madhukar, et al.
Publicado: (2010)

Synthesis and Cytotoxic Effect of Some Novel 1,2-Dihydropyridin-3-carbonitrile and Nicotinonitrile Derivatives
por: M. Flefel, Eman, et al.
Publicado: (2015)

Cytotoxic and Infection-Controlled Investigations of Novel Dihydropyridine Hybrids: An Efficient Synthesis and Molecular-Docking Studies
por: Guda, Mallikarjuna R., et al.
Publicado: (2023)

Green Synthesis and Anticancer Potential of 1,4-Dihydropyridines-Based Triazole Derivatives: In Silico and In Vitro Study
por: Bijani, Sabera, et al.
Publicado: (2022)

Synthesis of Non-Cytotoxic Poly(Ester-Amine) Dendrimers as Potential Solubility Enhancers for Drugs: Methotrexate as a Case Study
por: Soto-Castro, Delia, et al.
Publicado: (2010)

3,5-Bis(ethoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylic acid
por: Wu, De-Hong, et al.
Publicado: (2009)

Comparison between 1,2-Dihydropyridine and 1,4-Dihydropyridine on Hydride-Donating Ability and Activity
por: Zhang, Jin-Ye, et al.
Publicado: (2022)

Assessment of the Cytotoxic Effect of a Series of 1,4-Dihydropyridine Derivatives Against Human Cancer Cells
por: Razzaghi-Asl, Nima, et al.
Publicado: (2016)

First Gallium and Indium Crystal Structures of Curcuminoid Homoleptic Complexes: All-Different Ligand Stereochemistry and Cytotoxic Potential
por: Meza-Morales, William, et al.
Publicado: (2023)

2-Amino-5-chloropyridinium 6-oxo-1,6-dihydropyridine-2-carboxylate 0.85-hydrate
por: Hemamalini, Madhukar, et al.
Publicado: (2010)

Design, synthesis and in silico evaluation of newer 1,4-dihydropyridine based amlodipine bio-isosteres as promising antihypertensive agents
por: Takkar, Priya, et al.
Publicado: (2023)

New generations of dihydropyridines for treatment of hypertension
por: Wang, Angela L, et al.
Publicado: (2017)

Substituted Dihydropyridine Synthesis by Dearomatization of Pyridines
por: Heusler, Arne, et al.
Publicado: (2021)

In vitro evaluation of dihydropyridine-3-carbonitriles as potential cytotoxic agents through PIM-1 protein kinase inhibition
por: Abnous, Khalil, et al.
Publicado: (2017)

Synthesis of Fluorinated 3,6-Dihydropyridines and 2-(Fluoromethyl)pyridines by Electrophilic Fluorination of 1,2-Dihydropyridines with Selectfluor(®)
por: Pikun, Nadiia V., et al.
Publicado: (2020)

Diethyl 4-(biphenyl-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
por: Steiger, Scott A., et al.
Publicado: (2014)

A Theoretical Study of the Adsorption Process of B-aflatoxins Using Pyracantha koidzumii (Hayata) Rehder Biomasses
por: Méndez-Albores, Abraham, et al.
Publicado: (2020)

Green Approach—Multicomponent Production of Boron—Containing Hantzsch and Biginelli Esters
por: Martínez, Joel, et al.
Publicado: (2013)

Trisnor-Euphane-Type Triterpenoid and Other Constituents Isolated from Euphorbia tanquahuete Sessé & Moc.: Preparation and Cytotoxic Evaluation of Semisynthetic Derivatives of Euphol
por: Romero-Morán, Luis J., et al.
Publicado: (2022)

Influence of pHo on calcium channel block by amlodipine, a charged dihydropyridine compound. Implications for location of the dihydropyridine receptor
Publicado: (1989)

Novel 1,4-Dihydropyridine Derivatives as Mineralocorticoid Receptor Antagonists
por: Pérez-Gordillo, Felipe Luis, et al.
Publicado: (2023)

Synthesis of Curcuminoids and Evaluation of Their Cytotoxic and Antioxidant Properties
por: Lozada-García, María Concepción, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_gvo55l3h0p4sk7orf9km7dosuf