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Lipid-Lowering Therapy after Acute Coronary Syndrome in Outpatient Practice—How to Achieve Goal

Background: Secondary prevention of cardiovascular disease involves the use of optimal pharmacological treatment and modification of risk factors through lifestyle changes. Recent evidence demonstrates that the major initiating event in atherogenesis is the storage of low-density lipoproteins. Objec...

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Autores principales: Rajtar-Salwa, Renata, Bobrowska, Beata, Batko, Jakub, Bartuś, Stanisław, Petkow-Dimitrow, Paweł, Krawczyk-Ożóg, Agata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607515/
https://www.ncbi.nlm.nih.gov/pubmed/37892717
http://dx.doi.org/10.3390/jcm12206579
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author Rajtar-Salwa, Renata
Bobrowska, Beata
Batko, Jakub
Bartuś, Stanisław
Petkow-Dimitrow, Paweł
Krawczyk-Ożóg, Agata
author_facet Rajtar-Salwa, Renata
Bobrowska, Beata
Batko, Jakub
Bartuś, Stanisław
Petkow-Dimitrow, Paweł
Krawczyk-Ożóg, Agata
author_sort Rajtar-Salwa, Renata
collection PubMed
description Background: Secondary prevention of cardiovascular disease involves the use of optimal pharmacological treatment and modification of risk factors through lifestyle changes. Recent evidence demonstrates that the major initiating event in atherogenesis is the storage of low-density lipoproteins. Objectives: We aimed to compare the efficacy in achieving the therapeutic lipid target in relation to the frequency of follow-up at selected time points and to determine the safety and tolerability of cholesterol-lowering drugs (statins, ezetimibe). Methods: This was a prospective analysis of 72 consecutive patients hospitalized for acute coronary syndrome: ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI). Patients were consecutively divided into two groups: first, with follow-up and laboratory tests at 1, 3, 6 and 12 months after hospital discharge, including 32 patients; second, including 40 patients with follow-up and laboratory tests 12 months after hospital discharge. Results: A significant reduction in LDL-C level was observed at 12 months in both groups. LDL-C level was significantly lower in group 1 than in group 2 after 12 months (p = 0.02). Total cholesterol level was significantly lower in group 1 than in group 2 after 12 months. After 12 months of therapy, 21 (65.6%) patients in group 1 and 17 (42.5%) in group 2 had LDL-C < 1.4 mmol/L. In group 1, we observed a significant decrease in LDL-C, triglyceride, and total cholesterol levels at 1, 3, 6 and 12 months (p < 0.05). Conclusions: The group of patients with more frequent follow-up visits showed a greater reduction in LDL-C level than the group with only one visit after a 12-month hospital discharge.
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spelling pubmed-106075152023-10-28 Lipid-Lowering Therapy after Acute Coronary Syndrome in Outpatient Practice—How to Achieve Goal Rajtar-Salwa, Renata Bobrowska, Beata Batko, Jakub Bartuś, Stanisław Petkow-Dimitrow, Paweł Krawczyk-Ożóg, Agata J Clin Med Article Background: Secondary prevention of cardiovascular disease involves the use of optimal pharmacological treatment and modification of risk factors through lifestyle changes. Recent evidence demonstrates that the major initiating event in atherogenesis is the storage of low-density lipoproteins. Objectives: We aimed to compare the efficacy in achieving the therapeutic lipid target in relation to the frequency of follow-up at selected time points and to determine the safety and tolerability of cholesterol-lowering drugs (statins, ezetimibe). Methods: This was a prospective analysis of 72 consecutive patients hospitalized for acute coronary syndrome: ST-elevation myocardial infarction (STEMI) and non-ST-elevation myocardial infarction (NSTEMI). Patients were consecutively divided into two groups: first, with follow-up and laboratory tests at 1, 3, 6 and 12 months after hospital discharge, including 32 patients; second, including 40 patients with follow-up and laboratory tests 12 months after hospital discharge. Results: A significant reduction in LDL-C level was observed at 12 months in both groups. LDL-C level was significantly lower in group 1 than in group 2 after 12 months (p = 0.02). Total cholesterol level was significantly lower in group 1 than in group 2 after 12 months. After 12 months of therapy, 21 (65.6%) patients in group 1 and 17 (42.5%) in group 2 had LDL-C < 1.4 mmol/L. In group 1, we observed a significant decrease in LDL-C, triglyceride, and total cholesterol levels at 1, 3, 6 and 12 months (p < 0.05). Conclusions: The group of patients with more frequent follow-up visits showed a greater reduction in LDL-C level than the group with only one visit after a 12-month hospital discharge. MDPI 2023-10-17 /pmc/articles/PMC10607515/ /pubmed/37892717 http://dx.doi.org/10.3390/jcm12206579 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rajtar-Salwa, Renata
Bobrowska, Beata
Batko, Jakub
Bartuś, Stanisław
Petkow-Dimitrow, Paweł
Krawczyk-Ożóg, Agata
Lipid-Lowering Therapy after Acute Coronary Syndrome in Outpatient Practice—How to Achieve Goal
title Lipid-Lowering Therapy after Acute Coronary Syndrome in Outpatient Practice—How to Achieve Goal
title_full Lipid-Lowering Therapy after Acute Coronary Syndrome in Outpatient Practice—How to Achieve Goal
title_fullStr Lipid-Lowering Therapy after Acute Coronary Syndrome in Outpatient Practice—How to Achieve Goal
title_full_unstemmed Lipid-Lowering Therapy after Acute Coronary Syndrome in Outpatient Practice—How to Achieve Goal
title_short Lipid-Lowering Therapy after Acute Coronary Syndrome in Outpatient Practice—How to Achieve Goal
title_sort lipid-lowering therapy after acute coronary syndrome in outpatient practice—how to achieve goal
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607515/
https://www.ncbi.nlm.nih.gov/pubmed/37892717
http://dx.doi.org/10.3390/jcm12206579
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