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Histopathological Gap in Aortic Diseases: A Prospective Analysis

Aortic dissection (AD) is a critical cardiovascular condition with the potential for devastating consequences. This study evaluated the histological changes in the aorta wall in patients with AD and aortic aneurysm (AA) who received surgical aortic replacement. Histopathological data showed that mod...

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Autores principales: Banceu, Cosmin Marian, Gurzu, Simona, Satala, Catalin-Bogdan, Ghiga, Dana, Neamtu, Mihai Halic, Voth, Vladimir, Liebrich, Markus, Suciu, Horatiu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607681/
https://www.ncbi.nlm.nih.gov/pubmed/37895149
http://dx.doi.org/10.3390/ijms242015470
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author Banceu, Cosmin Marian
Gurzu, Simona
Satala, Catalin-Bogdan
Ghiga, Dana
Neamtu, Mihai Halic
Voth, Vladimir
Liebrich, Markus
Suciu, Horatiu
author_facet Banceu, Cosmin Marian
Gurzu, Simona
Satala, Catalin-Bogdan
Ghiga, Dana
Neamtu, Mihai Halic
Voth, Vladimir
Liebrich, Markus
Suciu, Horatiu
author_sort Banceu, Cosmin Marian
collection PubMed
description Aortic dissection (AD) is a critical cardiovascular condition with the potential for devastating consequences. This study evaluated the histological changes in the aorta wall in patients with AD and aortic aneurysm (AA) who received surgical aortic replacement. Histopathological data showed that modifications of the media layer (p = 0.0197), myxomatous aspect (p = 0.0001), and subendothelial layer degeneration (p = 0.0107) were more frequently seen in AA versus AD samples. Patients with AA were approximately twice as likely to develop histological changes than those with AD (p = 0.0037). Patients with moderate or severe medial degeneration had a higher chance of developing AD (p = 0.0001). Because the histopathological score proved to be a predictor of both in-hospital and overall mortality, its evaluation should become the standard of care in any patients who undergo aortic replacement. Individualized postoperative management might be influenced by the histopathological aspect of the aortic layer.
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spelling pubmed-106076812023-10-28 Histopathological Gap in Aortic Diseases: A Prospective Analysis Banceu, Cosmin Marian Gurzu, Simona Satala, Catalin-Bogdan Ghiga, Dana Neamtu, Mihai Halic Voth, Vladimir Liebrich, Markus Suciu, Horatiu Int J Mol Sci Article Aortic dissection (AD) is a critical cardiovascular condition with the potential for devastating consequences. This study evaluated the histological changes in the aorta wall in patients with AD and aortic aneurysm (AA) who received surgical aortic replacement. Histopathological data showed that modifications of the media layer (p = 0.0197), myxomatous aspect (p = 0.0001), and subendothelial layer degeneration (p = 0.0107) were more frequently seen in AA versus AD samples. Patients with AA were approximately twice as likely to develop histological changes than those with AD (p = 0.0037). Patients with moderate or severe medial degeneration had a higher chance of developing AD (p = 0.0001). Because the histopathological score proved to be a predictor of both in-hospital and overall mortality, its evaluation should become the standard of care in any patients who undergo aortic replacement. Individualized postoperative management might be influenced by the histopathological aspect of the aortic layer. MDPI 2023-10-23 /pmc/articles/PMC10607681/ /pubmed/37895149 http://dx.doi.org/10.3390/ijms242015470 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Banceu, Cosmin Marian
Gurzu, Simona
Satala, Catalin-Bogdan
Ghiga, Dana
Neamtu, Mihai Halic
Voth, Vladimir
Liebrich, Markus
Suciu, Horatiu
Histopathological Gap in Aortic Diseases: A Prospective Analysis
title Histopathological Gap in Aortic Diseases: A Prospective Analysis
title_full Histopathological Gap in Aortic Diseases: A Prospective Analysis
title_fullStr Histopathological Gap in Aortic Diseases: A Prospective Analysis
title_full_unstemmed Histopathological Gap in Aortic Diseases: A Prospective Analysis
title_short Histopathological Gap in Aortic Diseases: A Prospective Analysis
title_sort histopathological gap in aortic diseases: a prospective analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607681/
https://www.ncbi.nlm.nih.gov/pubmed/37895149
http://dx.doi.org/10.3390/ijms242015470
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