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Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers

Breast cancer (BC), one of the most widespread and devastating diseases affecting women worldwide, presents a significant public health challenge. This review explores the emerging frontiers of research focused on deciphering the intricate interplay between BC cells and the immune microenvironment....

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Autores principales: Kotsifaki, Amalia, Alevizopoulos, Nektarios, Dimopoulou, Vassiliki, Armakolas, Athanasios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607694/
https://www.ncbi.nlm.nih.gov/pubmed/37895012
http://dx.doi.org/10.3390/ijms242015332
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author Kotsifaki, Amalia
Alevizopoulos, Nektarios
Dimopoulou, Vassiliki
Armakolas, Athanasios
author_facet Kotsifaki, Amalia
Alevizopoulos, Nektarios
Dimopoulou, Vassiliki
Armakolas, Athanasios
author_sort Kotsifaki, Amalia
collection PubMed
description Breast cancer (BC), one of the most widespread and devastating diseases affecting women worldwide, presents a significant public health challenge. This review explores the emerging frontiers of research focused on deciphering the intricate interplay between BC cells and the immune microenvironment. Understanding the role of the immune system in BC is critical as it holds promise for novel therapeutic approaches and precision medicine strategies. This review delves into the current literature regarding the immune microenvironment’s contribution to BC initiation, progression, and metastasis. It examines the complex mechanisms by which BC cells interact with various immune cell populations, including tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). Furthermore, this review highlights the impact of immune-related factors, such as cytokines and immune checkpoint molecules. Additionally, this comprehensive analysis sheds light on the potential biomarkers associated with the immune response in BC, enabling early diagnosis and prognostic assessment. The therapeutic implications of targeting the immune microenvironment are also explored, encompassing immunotherapeutic strategies and combination therapies to enhance treatment efficacy. The significance of this review lies in its potential to pave the way for novel therapeutic interventions, providing clinicians and researchers with essential knowledge to design targeted and personalized treatment regimens for BC patients.
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spelling pubmed-106076942023-10-28 Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers Kotsifaki, Amalia Alevizopoulos, Nektarios Dimopoulou, Vassiliki Armakolas, Athanasios Int J Mol Sci Review Breast cancer (BC), one of the most widespread and devastating diseases affecting women worldwide, presents a significant public health challenge. This review explores the emerging frontiers of research focused on deciphering the intricate interplay between BC cells and the immune microenvironment. Understanding the role of the immune system in BC is critical as it holds promise for novel therapeutic approaches and precision medicine strategies. This review delves into the current literature regarding the immune microenvironment’s contribution to BC initiation, progression, and metastasis. It examines the complex mechanisms by which BC cells interact with various immune cell populations, including tumor-infiltrating lymphocytes (TILs) and tumor-associated macrophages (TAMs). Furthermore, this review highlights the impact of immune-related factors, such as cytokines and immune checkpoint molecules. Additionally, this comprehensive analysis sheds light on the potential biomarkers associated with the immune response in BC, enabling early diagnosis and prognostic assessment. The therapeutic implications of targeting the immune microenvironment are also explored, encompassing immunotherapeutic strategies and combination therapies to enhance treatment efficacy. The significance of this review lies in its potential to pave the way for novel therapeutic interventions, providing clinicians and researchers with essential knowledge to design targeted and personalized treatment regimens for BC patients. MDPI 2023-10-18 /pmc/articles/PMC10607694/ /pubmed/37895012 http://dx.doi.org/10.3390/ijms242015332 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kotsifaki, Amalia
Alevizopoulos, Nektarios
Dimopoulou, Vassiliki
Armakolas, Athanasios
Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers
title Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers
title_full Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers
title_fullStr Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers
title_full_unstemmed Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers
title_short Unveiling the Immune Microenvironment’s Role in Breast Cancer: A Glimpse into Promising Frontiers
title_sort unveiling the immune microenvironment’s role in breast cancer: a glimpse into promising frontiers
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607694/
https://www.ncbi.nlm.nih.gov/pubmed/37895012
http://dx.doi.org/10.3390/ijms242015332
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