Cargando…

Complete Blood Count Alterations Prior to the Diagnosis of Colorectal Cancer May Help in the Detection of Synchronous Liver Metastases

Background and Aims: Colorectal cancer (CRC) represents 10% of all cancers worldwide with the highest incidence in developed countries; its incidence is also increasing in middle- and low-income countries. Population screening programs facilitate early diagnosis of the disease. When the diagnosis is...

Descripción completa

Detalles Bibliográficos
Autores principales: Sala, Rafael J., Ery, John, Cuesta-Peredo, David, Muedra, Vicente, Rodilla, Vicent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607722/
https://www.ncbi.nlm.nih.gov/pubmed/37892677
http://dx.doi.org/10.3390/jcm12206540
_version_ 1785127608792383488
author Sala, Rafael J.
Ery, John
Cuesta-Peredo, David
Muedra, Vicente
Rodilla, Vicent
author_facet Sala, Rafael J.
Ery, John
Cuesta-Peredo, David
Muedra, Vicente
Rodilla, Vicent
author_sort Sala, Rafael J.
collection PubMed
description Background and Aims: Colorectal cancer (CRC) represents 10% of all cancers worldwide with the highest incidence in developed countries; its incidence is also increasing in middle- and low-income countries. Population screening programs facilitate early diagnosis of the disease. When the diagnosis is carried out in advanced stages, approximately 80% of patients with liver metastases (LM) are considered unresectable at the time of diagnosis. In our study, variations in blood counts prior to CRC diagnosis were analyzed to assess whether they could be useful in identifying smaller, more manageable metastases at earlier stages for more effective treatment. Methods: A study was carried out using complete blood counts (CBCs) from CRC patients, obtained from primary health centers and the La Ribera University Hospital within La Ribera Health Department, Valencian Community, Spain, between July 2012 and September 2020. Data from CRC patients who presented synchronous liver metastasis (CRLM) were compared with those with CRC without LM at diagnosis (CRC patients). Results: Our analysis shows that at least 15 months before CRC diagnosis, a progressive alteration was observed in CBC parameters in both groups. A higher incidence of anemia (p < 0.001) was observed among CRLM patients in the three months prior to CRC diagnosis than in CRC patients showing no LM. Conclusions: A statistically significant deterioration of CBC was observed in patients with advanced-stage CRC and synchronous or early LM (CRLM) in the three months prior to diagnosis. The primary goal of incorporating CBC variations into predictive models is to identify individuals who are at a greater risk of developing metastatic colon cancer, leading to early diagnosis. Our research improves these models by highlighting a more pronounced and rapid decline in hemoglobin levels among CRLM patients. Identification of metastases at an earlier stage when they are smaller, more manageable, and more amenable to treatment may be a valuable tool to prevent their further progression.
format Online
Article
Text
id pubmed-10607722
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106077222023-10-28 Complete Blood Count Alterations Prior to the Diagnosis of Colorectal Cancer May Help in the Detection of Synchronous Liver Metastases Sala, Rafael J. Ery, John Cuesta-Peredo, David Muedra, Vicente Rodilla, Vicent J Clin Med Article Background and Aims: Colorectal cancer (CRC) represents 10% of all cancers worldwide with the highest incidence in developed countries; its incidence is also increasing in middle- and low-income countries. Population screening programs facilitate early diagnosis of the disease. When the diagnosis is carried out in advanced stages, approximately 80% of patients with liver metastases (LM) are considered unresectable at the time of diagnosis. In our study, variations in blood counts prior to CRC diagnosis were analyzed to assess whether they could be useful in identifying smaller, more manageable metastases at earlier stages for more effective treatment. Methods: A study was carried out using complete blood counts (CBCs) from CRC patients, obtained from primary health centers and the La Ribera University Hospital within La Ribera Health Department, Valencian Community, Spain, between July 2012 and September 2020. Data from CRC patients who presented synchronous liver metastasis (CRLM) were compared with those with CRC without LM at diagnosis (CRC patients). Results: Our analysis shows that at least 15 months before CRC diagnosis, a progressive alteration was observed in CBC parameters in both groups. A higher incidence of anemia (p < 0.001) was observed among CRLM patients in the three months prior to CRC diagnosis than in CRC patients showing no LM. Conclusions: A statistically significant deterioration of CBC was observed in patients with advanced-stage CRC and synchronous or early LM (CRLM) in the three months prior to diagnosis. The primary goal of incorporating CBC variations into predictive models is to identify individuals who are at a greater risk of developing metastatic colon cancer, leading to early diagnosis. Our research improves these models by highlighting a more pronounced and rapid decline in hemoglobin levels among CRLM patients. Identification of metastases at an earlier stage when they are smaller, more manageable, and more amenable to treatment may be a valuable tool to prevent their further progression. MDPI 2023-10-15 /pmc/articles/PMC10607722/ /pubmed/37892677 http://dx.doi.org/10.3390/jcm12206540 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sala, Rafael J.
Ery, John
Cuesta-Peredo, David
Muedra, Vicente
Rodilla, Vicent
Complete Blood Count Alterations Prior to the Diagnosis of Colorectal Cancer May Help in the Detection of Synchronous Liver Metastases
title Complete Blood Count Alterations Prior to the Diagnosis of Colorectal Cancer May Help in the Detection of Synchronous Liver Metastases
title_full Complete Blood Count Alterations Prior to the Diagnosis of Colorectal Cancer May Help in the Detection of Synchronous Liver Metastases
title_fullStr Complete Blood Count Alterations Prior to the Diagnosis of Colorectal Cancer May Help in the Detection of Synchronous Liver Metastases
title_full_unstemmed Complete Blood Count Alterations Prior to the Diagnosis of Colorectal Cancer May Help in the Detection of Synchronous Liver Metastases
title_short Complete Blood Count Alterations Prior to the Diagnosis of Colorectal Cancer May Help in the Detection of Synchronous Liver Metastases
title_sort complete blood count alterations prior to the diagnosis of colorectal cancer may help in the detection of synchronous liver metastases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607722/
https://www.ncbi.nlm.nih.gov/pubmed/37892677
http://dx.doi.org/10.3390/jcm12206540
work_keys_str_mv AT salarafaelj completebloodcountalterationspriortothediagnosisofcolorectalcancermayhelpinthedetectionofsynchronouslivermetastases
AT eryjohn completebloodcountalterationspriortothediagnosisofcolorectalcancermayhelpinthedetectionofsynchronouslivermetastases
AT cuestaperedodavid completebloodcountalterationspriortothediagnosisofcolorectalcancermayhelpinthedetectionofsynchronouslivermetastases
AT muedravicente completebloodcountalterationspriortothediagnosisofcolorectalcancermayhelpinthedetectionofsynchronouslivermetastases
AT rodillavicent completebloodcountalterationspriortothediagnosisofcolorectalcancermayhelpinthedetectionofsynchronouslivermetastases