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Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement

Recipients of uterus transplantation have unique factors that may increase their risk of cervical insufficiency. This report describes a uterus transplant recipient with cervical insufficiency resulting in two second-trimester miscarriages. After McDonald cerclages (one that failed), she underwent a...

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Autores principales: Johannesson, Liza, Anderson, Sophie, Putman, J. Michael, Gunby, Robert T., Zhang, Lilly, Testa, Giuliano, Gregg, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607750/
https://www.ncbi.nlm.nih.gov/pubmed/37892602
http://dx.doi.org/10.3390/jcm12206463
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author Johannesson, Liza
Anderson, Sophie
Putman, J. Michael
Gunby, Robert T.
Zhang, Lilly
Testa, Giuliano
Gregg, Anthony R.
author_facet Johannesson, Liza
Anderson, Sophie
Putman, J. Michael
Gunby, Robert T.
Zhang, Lilly
Testa, Giuliano
Gregg, Anthony R.
author_sort Johannesson, Liza
collection PubMed
description Recipients of uterus transplantation have unique factors that may increase their risk of cervical insufficiency. This report describes a uterus transplant recipient with cervical insufficiency resulting in two second-trimester miscarriages. After McDonald cerclages (one that failed), she underwent an interval transabdominal cerclage and delivered a healthy term child in her third pregnancy. The longitudinal information of this case provides observations from which we can propose testable hypotheses that address venous outflow and inflammation. This case also suggests that there could be a role for prophylactic cerclage placement at the time of transplantation.
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spelling pubmed-106077502023-10-28 Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement Johannesson, Liza Anderson, Sophie Putman, J. Michael Gunby, Robert T. Zhang, Lilly Testa, Giuliano Gregg, Anthony R. J Clin Med Case Report Recipients of uterus transplantation have unique factors that may increase their risk of cervical insufficiency. This report describes a uterus transplant recipient with cervical insufficiency resulting in two second-trimester miscarriages. After McDonald cerclages (one that failed), she underwent an interval transabdominal cerclage and delivered a healthy term child in her third pregnancy. The longitudinal information of this case provides observations from which we can propose testable hypotheses that address venous outflow and inflammation. This case also suggests that there could be a role for prophylactic cerclage placement at the time of transplantation. MDPI 2023-10-11 /pmc/articles/PMC10607750/ /pubmed/37892602 http://dx.doi.org/10.3390/jcm12206463 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Johannesson, Liza
Anderson, Sophie
Putman, J. Michael
Gunby, Robert T.
Zhang, Lilly
Testa, Giuliano
Gregg, Anthony R.
Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement
title Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement
title_full Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement
title_fullStr Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement
title_full_unstemmed Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement
title_short Persistence Pays Off: Live Birth after Uterus Transplant, Overcoming Recurrent Pregnancy Loss with Cerclage Placement
title_sort persistence pays off: live birth after uterus transplant, overcoming recurrent pregnancy loss with cerclage placement
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607750/
https://www.ncbi.nlm.nih.gov/pubmed/37892602
http://dx.doi.org/10.3390/jcm12206463
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