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The Performance of Flash Replenishment Contrast-Enhanced Ultrasound for the Qualitative Assessment of Kidney Lesions in Patients with Chronic Kidney Disease

We investigated the accuracy of CEUS for characterizing cystic and solid kidney lesions in patients with chronic kidney disease (CKD). Cystic lesions are assessed using Bosniak criteria for computed tomography (CT) and magnetic resonance imaging (MRI); however, in patients with moderate to severe ki...

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Autores principales: Walmer, Rachel W., Ritter, Victor S., Sridharan, Anush, Kasoji, Sandeep K., Altun, Ersan, Lee, Ellie, Olinger, Kristen, Wagner, Sean, Radhakrishna, Roshni, Johnson, Kennita A., Rathmell, W. Kimryn, Qaqish, Bahjat, Dayton, Paul A., Chang, Emily H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607866/
https://www.ncbi.nlm.nih.gov/pubmed/37892632
http://dx.doi.org/10.3390/jcm12206494
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author Walmer, Rachel W.
Ritter, Victor S.
Sridharan, Anush
Kasoji, Sandeep K.
Altun, Ersan
Lee, Ellie
Olinger, Kristen
Wagner, Sean
Radhakrishna, Roshni
Johnson, Kennita A.
Rathmell, W. Kimryn
Qaqish, Bahjat
Dayton, Paul A.
Chang, Emily H.
author_facet Walmer, Rachel W.
Ritter, Victor S.
Sridharan, Anush
Kasoji, Sandeep K.
Altun, Ersan
Lee, Ellie
Olinger, Kristen
Wagner, Sean
Radhakrishna, Roshni
Johnson, Kennita A.
Rathmell, W. Kimryn
Qaqish, Bahjat
Dayton, Paul A.
Chang, Emily H.
author_sort Walmer, Rachel W.
collection PubMed
description We investigated the accuracy of CEUS for characterizing cystic and solid kidney lesions in patients with chronic kidney disease (CKD). Cystic lesions are assessed using Bosniak criteria for computed tomography (CT) and magnetic resonance imaging (MRI); however, in patients with moderate to severe kidney disease, CT and MRI contrast agents may be contraindicated. Contrast-enhanced ultrasound (CEUS) is a safe alternative for characterizing these lesions, but data on its performance among CKD patients are limited. We performed flash replenishment CEUS in 60 CKD patients (73 lesions). Final analysis included 53 patients (63 lesions). Four readers, blinded to true diagnosis, interpreted each lesion. Reader evaluations were compared to true lesion classifications. Performance metrics were calculated to assess malignant and benign diagnoses. Reader agreement was evaluated using Bowker’s symmetry test. Combined reader sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for diagnosing malignant lesions were 71%, 75%, 45%, and 90%, respectively. Sensitivity (81%) and specificity (83%) were highest in CKD IV/V patients when grouped by CKD stage. Combined reader sensitivity, specificity, PPV, and NPV for diagnosing benign lesions were 70%, 86%, 91%, and 61%, respectively. Again, in CKD IV/V patients, sensitivity (81%), specificity (95%), and PPV (98%) were highest. Inter-reader diagnostic agreement varied from 72% to 90%. In CKD patients, CEUS is a potential low-risk option for screening kidney lesions. CEUS may be particularly beneficial for CKD IV/V patients, where kidney preservation techniques are highly relevant.
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spelling pubmed-106078662023-10-28 The Performance of Flash Replenishment Contrast-Enhanced Ultrasound for the Qualitative Assessment of Kidney Lesions in Patients with Chronic Kidney Disease Walmer, Rachel W. Ritter, Victor S. Sridharan, Anush Kasoji, Sandeep K. Altun, Ersan Lee, Ellie Olinger, Kristen Wagner, Sean Radhakrishna, Roshni Johnson, Kennita A. Rathmell, W. Kimryn Qaqish, Bahjat Dayton, Paul A. Chang, Emily H. J Clin Med Article We investigated the accuracy of CEUS for characterizing cystic and solid kidney lesions in patients with chronic kidney disease (CKD). Cystic lesions are assessed using Bosniak criteria for computed tomography (CT) and magnetic resonance imaging (MRI); however, in patients with moderate to severe kidney disease, CT and MRI contrast agents may be contraindicated. Contrast-enhanced ultrasound (CEUS) is a safe alternative for characterizing these lesions, but data on its performance among CKD patients are limited. We performed flash replenishment CEUS in 60 CKD patients (73 lesions). Final analysis included 53 patients (63 lesions). Four readers, blinded to true diagnosis, interpreted each lesion. Reader evaluations were compared to true lesion classifications. Performance metrics were calculated to assess malignant and benign diagnoses. Reader agreement was evaluated using Bowker’s symmetry test. Combined reader sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) for diagnosing malignant lesions were 71%, 75%, 45%, and 90%, respectively. Sensitivity (81%) and specificity (83%) were highest in CKD IV/V patients when grouped by CKD stage. Combined reader sensitivity, specificity, PPV, and NPV for diagnosing benign lesions were 70%, 86%, 91%, and 61%, respectively. Again, in CKD IV/V patients, sensitivity (81%), specificity (95%), and PPV (98%) were highest. Inter-reader diagnostic agreement varied from 72% to 90%. In CKD patients, CEUS is a potential low-risk option for screening kidney lesions. CEUS may be particularly beneficial for CKD IV/V patients, where kidney preservation techniques are highly relevant. MDPI 2023-10-12 /pmc/articles/PMC10607866/ /pubmed/37892632 http://dx.doi.org/10.3390/jcm12206494 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Walmer, Rachel W.
Ritter, Victor S.
Sridharan, Anush
Kasoji, Sandeep K.
Altun, Ersan
Lee, Ellie
Olinger, Kristen
Wagner, Sean
Radhakrishna, Roshni
Johnson, Kennita A.
Rathmell, W. Kimryn
Qaqish, Bahjat
Dayton, Paul A.
Chang, Emily H.
The Performance of Flash Replenishment Contrast-Enhanced Ultrasound for the Qualitative Assessment of Kidney Lesions in Patients with Chronic Kidney Disease
title The Performance of Flash Replenishment Contrast-Enhanced Ultrasound for the Qualitative Assessment of Kidney Lesions in Patients with Chronic Kidney Disease
title_full The Performance of Flash Replenishment Contrast-Enhanced Ultrasound for the Qualitative Assessment of Kidney Lesions in Patients with Chronic Kidney Disease
title_fullStr The Performance of Flash Replenishment Contrast-Enhanced Ultrasound for the Qualitative Assessment of Kidney Lesions in Patients with Chronic Kidney Disease
title_full_unstemmed The Performance of Flash Replenishment Contrast-Enhanced Ultrasound for the Qualitative Assessment of Kidney Lesions in Patients with Chronic Kidney Disease
title_short The Performance of Flash Replenishment Contrast-Enhanced Ultrasound for the Qualitative Assessment of Kidney Lesions in Patients with Chronic Kidney Disease
title_sort performance of flash replenishment contrast-enhanced ultrasound for the qualitative assessment of kidney lesions in patients with chronic kidney disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607866/
https://www.ncbi.nlm.nih.gov/pubmed/37892632
http://dx.doi.org/10.3390/jcm12206494
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