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Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014
(1) Background: Epidemiological studies on the relationship between serum copper and hypertension are contradictory. We assessed the relationship between serum copper and blood pressure among adults in the United States. (2) Methods: We divided hypertension into two categories: treated hypertension...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607875/ https://www.ncbi.nlm.nih.gov/pubmed/37887879 http://dx.doi.org/10.3390/jcdd10100432 |
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author | Xu, Ruo-Nan Zhang, Yue Xu, Xin Li, Xu He, Lan Feng, Qiang Yang, Yong-Hai He, Yang Ma, Xiao He, Yong-Ming |
author_facet | Xu, Ruo-Nan Zhang, Yue Xu, Xin Li, Xu He, Lan Feng, Qiang Yang, Yong-Hai He, Yang Ma, Xiao He, Yong-Ming |
author_sort | Xu, Ruo-Nan |
collection | PubMed |
description | (1) Background: Epidemiological studies on the relationship between serum copper and hypertension are contradictory. We assessed the relationship between serum copper and blood pressure among adults in the United States. (2) Methods: We divided hypertension into two categories: treated hypertension and untreated hypertension. Linear or logistic regression analysis was applied to investigate the association between serum copper concentrations and blood pressure levels. (3) Results: As compared to quartile 1, the odds ratios (ORs) for untreated hypertension in quartiles 2, 3, and 4 were 1.02 (0.74–1.42), 1.23 (0.88–1.72), and 1.08 (0.74–1.58), respectively, in multivariable analysis (all p > 0.05). In non-hypertension, as compared with quartile 1, the β (95% CI) of systolic blood pressure for quartiles 2, 3, and 4 was −0.92 (−2.07–0.23), −0.05 (−1.30–1.20), and −0.48 (−1.83–0.88), respectively, in multivariable analysis (all p > 0.05). As compared to quartile 1, the ORs for treated hypertension in quartiles 2, 3, and 4 were 1.36 (0.88–2.10), 1.35 (0.87–2.09), and 1.56 (0.98–2.47), respectively, upon multivariable analysis including antihypertensive medication use as a covariate (all p > 0.05). Furthermore, 1SD increase in serum copper was non-significantly associated with 1.16 (0.97–1.37)-fold increased risk of hypertension in multivariable analysis (p = 0.096). (4) Conclusion: In the present study, we discovered that the serum copper concentration was not related with hypertension or blood pressure levels. Antihypertensive drug use may distort the correlation between copper and blood pressure levels. Information on antihypertensive drug use may be taken into account when identifying new risk factors for hypertension. |
format | Online Article Text |
id | pubmed-10607875 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106078752023-10-28 Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014 Xu, Ruo-Nan Zhang, Yue Xu, Xin Li, Xu He, Lan Feng, Qiang Yang, Yong-Hai He, Yang Ma, Xiao He, Yong-Ming J Cardiovasc Dev Dis Article (1) Background: Epidemiological studies on the relationship between serum copper and hypertension are contradictory. We assessed the relationship between serum copper and blood pressure among adults in the United States. (2) Methods: We divided hypertension into two categories: treated hypertension and untreated hypertension. Linear or logistic regression analysis was applied to investigate the association between serum copper concentrations and blood pressure levels. (3) Results: As compared to quartile 1, the odds ratios (ORs) for untreated hypertension in quartiles 2, 3, and 4 were 1.02 (0.74–1.42), 1.23 (0.88–1.72), and 1.08 (0.74–1.58), respectively, in multivariable analysis (all p > 0.05). In non-hypertension, as compared with quartile 1, the β (95% CI) of systolic blood pressure for quartiles 2, 3, and 4 was −0.92 (−2.07–0.23), −0.05 (−1.30–1.20), and −0.48 (−1.83–0.88), respectively, in multivariable analysis (all p > 0.05). As compared to quartile 1, the ORs for treated hypertension in quartiles 2, 3, and 4 were 1.36 (0.88–2.10), 1.35 (0.87–2.09), and 1.56 (0.98–2.47), respectively, upon multivariable analysis including antihypertensive medication use as a covariate (all p > 0.05). Furthermore, 1SD increase in serum copper was non-significantly associated with 1.16 (0.97–1.37)-fold increased risk of hypertension in multivariable analysis (p = 0.096). (4) Conclusion: In the present study, we discovered that the serum copper concentration was not related with hypertension or blood pressure levels. Antihypertensive drug use may distort the correlation between copper and blood pressure levels. Information on antihypertensive drug use may be taken into account when identifying new risk factors for hypertension. MDPI 2023-10-18 /pmc/articles/PMC10607875/ /pubmed/37887879 http://dx.doi.org/10.3390/jcdd10100432 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Xu, Ruo-Nan Zhang, Yue Xu, Xin Li, Xu He, Lan Feng, Qiang Yang, Yong-Hai He, Yang Ma, Xiao He, Yong-Ming Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014 |
title | Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014 |
title_full | Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014 |
title_fullStr | Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014 |
title_full_unstemmed | Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014 |
title_short | Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014 |
title_sort | serum copper concentrations, effect modifiers and blood pressure: insights from nhanes 2011–2014 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607875/ https://www.ncbi.nlm.nih.gov/pubmed/37887879 http://dx.doi.org/10.3390/jcdd10100432 |
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