Cargando…

Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014

(1) Background: Epidemiological studies on the relationship between serum copper and hypertension are contradictory. We assessed the relationship between serum copper and blood pressure among adults in the United States. (2) Methods: We divided hypertension into two categories: treated hypertension...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Ruo-Nan, Zhang, Yue, Xu, Xin, Li, Xu, He, Lan, Feng, Qiang, Yang, Yong-Hai, He, Yang, Ma, Xiao, He, Yong-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607875/
https://www.ncbi.nlm.nih.gov/pubmed/37887879
http://dx.doi.org/10.3390/jcdd10100432
_version_ 1785127646327209984
author Xu, Ruo-Nan
Zhang, Yue
Xu, Xin
Li, Xu
He, Lan
Feng, Qiang
Yang, Yong-Hai
He, Yang
Ma, Xiao
He, Yong-Ming
author_facet Xu, Ruo-Nan
Zhang, Yue
Xu, Xin
Li, Xu
He, Lan
Feng, Qiang
Yang, Yong-Hai
He, Yang
Ma, Xiao
He, Yong-Ming
author_sort Xu, Ruo-Nan
collection PubMed
description (1) Background: Epidemiological studies on the relationship between serum copper and hypertension are contradictory. We assessed the relationship between serum copper and blood pressure among adults in the United States. (2) Methods: We divided hypertension into two categories: treated hypertension and untreated hypertension. Linear or logistic regression analysis was applied to investigate the association between serum copper concentrations and blood pressure levels. (3) Results: As compared to quartile 1, the odds ratios (ORs) for untreated hypertension in quartiles 2, 3, and 4 were 1.02 (0.74–1.42), 1.23 (0.88–1.72), and 1.08 (0.74–1.58), respectively, in multivariable analysis (all p > 0.05). In non-hypertension, as compared with quartile 1, the β (95% CI) of systolic blood pressure for quartiles 2, 3, and 4 was −0.92 (−2.07–0.23), −0.05 (−1.30–1.20), and −0.48 (−1.83–0.88), respectively, in multivariable analysis (all p > 0.05). As compared to quartile 1, the ORs for treated hypertension in quartiles 2, 3, and 4 were 1.36 (0.88–2.10), 1.35 (0.87–2.09), and 1.56 (0.98–2.47), respectively, upon multivariable analysis including antihypertensive medication use as a covariate (all p > 0.05). Furthermore, 1SD increase in serum copper was non-significantly associated with 1.16 (0.97–1.37)-fold increased risk of hypertension in multivariable analysis (p = 0.096). (4) Conclusion: In the present study, we discovered that the serum copper concentration was not related with hypertension or blood pressure levels. Antihypertensive drug use may distort the correlation between copper and blood pressure levels. Information on antihypertensive drug use may be taken into account when identifying new risk factors for hypertension.
format Online
Article
Text
id pubmed-10607875
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-106078752023-10-28 Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014 Xu, Ruo-Nan Zhang, Yue Xu, Xin Li, Xu He, Lan Feng, Qiang Yang, Yong-Hai He, Yang Ma, Xiao He, Yong-Ming J Cardiovasc Dev Dis Article (1) Background: Epidemiological studies on the relationship between serum copper and hypertension are contradictory. We assessed the relationship between serum copper and blood pressure among adults in the United States. (2) Methods: We divided hypertension into two categories: treated hypertension and untreated hypertension. Linear or logistic regression analysis was applied to investigate the association between serum copper concentrations and blood pressure levels. (3) Results: As compared to quartile 1, the odds ratios (ORs) for untreated hypertension in quartiles 2, 3, and 4 were 1.02 (0.74–1.42), 1.23 (0.88–1.72), and 1.08 (0.74–1.58), respectively, in multivariable analysis (all p > 0.05). In non-hypertension, as compared with quartile 1, the β (95% CI) of systolic blood pressure for quartiles 2, 3, and 4 was −0.92 (−2.07–0.23), −0.05 (−1.30–1.20), and −0.48 (−1.83–0.88), respectively, in multivariable analysis (all p > 0.05). As compared to quartile 1, the ORs for treated hypertension in quartiles 2, 3, and 4 were 1.36 (0.88–2.10), 1.35 (0.87–2.09), and 1.56 (0.98–2.47), respectively, upon multivariable analysis including antihypertensive medication use as a covariate (all p > 0.05). Furthermore, 1SD increase in serum copper was non-significantly associated with 1.16 (0.97–1.37)-fold increased risk of hypertension in multivariable analysis (p = 0.096). (4) Conclusion: In the present study, we discovered that the serum copper concentration was not related with hypertension or blood pressure levels. Antihypertensive drug use may distort the correlation between copper and blood pressure levels. Information on antihypertensive drug use may be taken into account when identifying new risk factors for hypertension. MDPI 2023-10-18 /pmc/articles/PMC10607875/ /pubmed/37887879 http://dx.doi.org/10.3390/jcdd10100432 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Xu, Ruo-Nan
Zhang, Yue
Xu, Xin
Li, Xu
He, Lan
Feng, Qiang
Yang, Yong-Hai
He, Yang
Ma, Xiao
He, Yong-Ming
Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014
title Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014
title_full Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014
title_fullStr Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014
title_full_unstemmed Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014
title_short Serum Copper Concentrations, Effect Modifiers and Blood Pressure: Insights from NHANES 2011–2014
title_sort serum copper concentrations, effect modifiers and blood pressure: insights from nhanes 2011–2014
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607875/
https://www.ncbi.nlm.nih.gov/pubmed/37887879
http://dx.doi.org/10.3390/jcdd10100432
work_keys_str_mv AT xuruonan serumcopperconcentrationseffectmodifiersandbloodpressureinsightsfromnhanes20112014
AT zhangyue serumcopperconcentrationseffectmodifiersandbloodpressureinsightsfromnhanes20112014
AT xuxin serumcopperconcentrationseffectmodifiersandbloodpressureinsightsfromnhanes20112014
AT lixu serumcopperconcentrationseffectmodifiersandbloodpressureinsightsfromnhanes20112014
AT helan serumcopperconcentrationseffectmodifiersandbloodpressureinsightsfromnhanes20112014
AT fengqiang serumcopperconcentrationseffectmodifiersandbloodpressureinsightsfromnhanes20112014
AT yangyonghai serumcopperconcentrationseffectmodifiersandbloodpressureinsightsfromnhanes20112014
AT heyang serumcopperconcentrationseffectmodifiersandbloodpressureinsightsfromnhanes20112014
AT maxiao serumcopperconcentrationseffectmodifiersandbloodpressureinsightsfromnhanes20112014
AT heyongming serumcopperconcentrationseffectmodifiersandbloodpressureinsightsfromnhanes20112014