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Lupus Nephritis in Children: Novel Perspectives

Childhood-onset systemic lupus erythematosus is an inflammatory and autoimmune condition characterized by heterogeneous multisystem involvement and a chronic course with unpredictable flares. Kidney involvement, commonly called lupus nephritis, mainly presents with immune complex-mediated glomerulon...

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Detalles Bibliográficos
Autores principales: Pennesi, Marco, Benvenuto, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607957/
https://www.ncbi.nlm.nih.gov/pubmed/37893559
http://dx.doi.org/10.3390/medicina59101841
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author Pennesi, Marco
Benvenuto, Simone
author_facet Pennesi, Marco
Benvenuto, Simone
author_sort Pennesi, Marco
collection PubMed
description Childhood-onset systemic lupus erythematosus is an inflammatory and autoimmune condition characterized by heterogeneous multisystem involvement and a chronic course with unpredictable flares. Kidney involvement, commonly called lupus nephritis, mainly presents with immune complex-mediated glomerulonephritis and is more frequent and severe in adults. Despite a considerable improvement in long-term renal prognosis, children and adolescents with lupus nephritis still experience significant morbidity and mortality. Moreover, current literature often lacks pediatric-specific data, leading clinicians to rely exclusively on adult therapeutic approaches. This review aims to describe pediatric lupus nephritis and provide an overview of the novel perspectives on the pathogenetic mechanisms, histopathological classification, therapeutic approach, novel biomarkers, and follow-up targets in children and adolescents with lupus nephritis.
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spelling pubmed-106079572023-10-28 Lupus Nephritis in Children: Novel Perspectives Pennesi, Marco Benvenuto, Simone Medicina (Kaunas) Review Childhood-onset systemic lupus erythematosus is an inflammatory and autoimmune condition characterized by heterogeneous multisystem involvement and a chronic course with unpredictable flares. Kidney involvement, commonly called lupus nephritis, mainly presents with immune complex-mediated glomerulonephritis and is more frequent and severe in adults. Despite a considerable improvement in long-term renal prognosis, children and adolescents with lupus nephritis still experience significant morbidity and mortality. Moreover, current literature often lacks pediatric-specific data, leading clinicians to rely exclusively on adult therapeutic approaches. This review aims to describe pediatric lupus nephritis and provide an overview of the novel perspectives on the pathogenetic mechanisms, histopathological classification, therapeutic approach, novel biomarkers, and follow-up targets in children and adolescents with lupus nephritis. MDPI 2023-10-16 /pmc/articles/PMC10607957/ /pubmed/37893559 http://dx.doi.org/10.3390/medicina59101841 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pennesi, Marco
Benvenuto, Simone
Lupus Nephritis in Children: Novel Perspectives
title Lupus Nephritis in Children: Novel Perspectives
title_full Lupus Nephritis in Children: Novel Perspectives
title_fullStr Lupus Nephritis in Children: Novel Perspectives
title_full_unstemmed Lupus Nephritis in Children: Novel Perspectives
title_short Lupus Nephritis in Children: Novel Perspectives
title_sort lupus nephritis in children: novel perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607957/
https://www.ncbi.nlm.nih.gov/pubmed/37893559
http://dx.doi.org/10.3390/medicina59101841
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