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Lupus Nephritis in Children: Novel Perspectives
Childhood-onset systemic lupus erythematosus is an inflammatory and autoimmune condition characterized by heterogeneous multisystem involvement and a chronic course with unpredictable flares. Kidney involvement, commonly called lupus nephritis, mainly presents with immune complex-mediated glomerulon...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607957/ https://www.ncbi.nlm.nih.gov/pubmed/37893559 http://dx.doi.org/10.3390/medicina59101841 |
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author | Pennesi, Marco Benvenuto, Simone |
author_facet | Pennesi, Marco Benvenuto, Simone |
author_sort | Pennesi, Marco |
collection | PubMed |
description | Childhood-onset systemic lupus erythematosus is an inflammatory and autoimmune condition characterized by heterogeneous multisystem involvement and a chronic course with unpredictable flares. Kidney involvement, commonly called lupus nephritis, mainly presents with immune complex-mediated glomerulonephritis and is more frequent and severe in adults. Despite a considerable improvement in long-term renal prognosis, children and adolescents with lupus nephritis still experience significant morbidity and mortality. Moreover, current literature often lacks pediatric-specific data, leading clinicians to rely exclusively on adult therapeutic approaches. This review aims to describe pediatric lupus nephritis and provide an overview of the novel perspectives on the pathogenetic mechanisms, histopathological classification, therapeutic approach, novel biomarkers, and follow-up targets in children and adolescents with lupus nephritis. |
format | Online Article Text |
id | pubmed-10607957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106079572023-10-28 Lupus Nephritis in Children: Novel Perspectives Pennesi, Marco Benvenuto, Simone Medicina (Kaunas) Review Childhood-onset systemic lupus erythematosus is an inflammatory and autoimmune condition characterized by heterogeneous multisystem involvement and a chronic course with unpredictable flares. Kidney involvement, commonly called lupus nephritis, mainly presents with immune complex-mediated glomerulonephritis and is more frequent and severe in adults. Despite a considerable improvement in long-term renal prognosis, children and adolescents with lupus nephritis still experience significant morbidity and mortality. Moreover, current literature often lacks pediatric-specific data, leading clinicians to rely exclusively on adult therapeutic approaches. This review aims to describe pediatric lupus nephritis and provide an overview of the novel perspectives on the pathogenetic mechanisms, histopathological classification, therapeutic approach, novel biomarkers, and follow-up targets in children and adolescents with lupus nephritis. MDPI 2023-10-16 /pmc/articles/PMC10607957/ /pubmed/37893559 http://dx.doi.org/10.3390/medicina59101841 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Pennesi, Marco Benvenuto, Simone Lupus Nephritis in Children: Novel Perspectives |
title | Lupus Nephritis in Children: Novel Perspectives |
title_full | Lupus Nephritis in Children: Novel Perspectives |
title_fullStr | Lupus Nephritis in Children: Novel Perspectives |
title_full_unstemmed | Lupus Nephritis in Children: Novel Perspectives |
title_short | Lupus Nephritis in Children: Novel Perspectives |
title_sort | lupus nephritis in children: novel perspectives |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10607957/ https://www.ncbi.nlm.nih.gov/pubmed/37893559 http://dx.doi.org/10.3390/medicina59101841 |
work_keys_str_mv | AT pennesimarco lupusnephritisinchildrennovelperspectives AT benvenutosimone lupusnephritisinchildrennovelperspectives |