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The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review

Background: Several studies have been conducted to prove the bidirectional relationship between cardiovascular disease (CVD) and depression. These two major illnesses share several common risk factors such that the development of either condition may increase the risk of the occurrence of the other....

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Autores principales: Fioranelli, Massimo, Roccia, Maria Grazia, Przybylek, Bianca, Garo, Maria Luisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608007/
https://www.ncbi.nlm.nih.gov/pubmed/37895349
http://dx.doi.org/10.3390/life13101967
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author Fioranelli, Massimo
Roccia, Maria Grazia
Przybylek, Bianca
Garo, Maria Luisa
author_facet Fioranelli, Massimo
Roccia, Maria Grazia
Przybylek, Bianca
Garo, Maria Luisa
author_sort Fioranelli, Massimo
collection PubMed
description Background: Several studies have been conducted to prove the bidirectional relationship between cardiovascular disease (CVD) and depression. These two major illnesses share several common risk factors such that the development of either condition may increase the risk of the occurrence of the other. Brain-derived neurotrophic factor (BDNF) has been suggested as a reliable biomarker for depression and a strong predictor of CVD because it plays an important role in neuron survival and growth, serves as a neurotransmitter modulator, and promotes neuronal plasticity. The aim of this systematic review was to examine the bidirectional relationship between CVD and depression, focusing on the potential role of low serum BDNF levels in the development of either disease in the presence of the other. Methods: A systematic search strategy was developed using PRISMA guidelines. Results: Six studies (comprising 1251 patients) were identified, all of which examined the association between CVD and depression. Conclusions: It was found that there may be a strong association between low serum BDNF levels and the risk of post-stroke depression. However, the studies on the role of altered serum BDNF levels and other types of CVD are few. Therefore, the inverse association between depression and CVD cannot be proven.
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spelling pubmed-106080072023-10-28 The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review Fioranelli, Massimo Roccia, Maria Grazia Przybylek, Bianca Garo, Maria Luisa Life (Basel) Systematic Review Background: Several studies have been conducted to prove the bidirectional relationship between cardiovascular disease (CVD) and depression. These two major illnesses share several common risk factors such that the development of either condition may increase the risk of the occurrence of the other. Brain-derived neurotrophic factor (BDNF) has been suggested as a reliable biomarker for depression and a strong predictor of CVD because it plays an important role in neuron survival and growth, serves as a neurotransmitter modulator, and promotes neuronal plasticity. The aim of this systematic review was to examine the bidirectional relationship between CVD and depression, focusing on the potential role of low serum BDNF levels in the development of either disease in the presence of the other. Methods: A systematic search strategy was developed using PRISMA guidelines. Results: Six studies (comprising 1251 patients) were identified, all of which examined the association between CVD and depression. Conclusions: It was found that there may be a strong association between low serum BDNF levels and the risk of post-stroke depression. However, the studies on the role of altered serum BDNF levels and other types of CVD are few. Therefore, the inverse association between depression and CVD cannot be proven. MDPI 2023-09-26 /pmc/articles/PMC10608007/ /pubmed/37895349 http://dx.doi.org/10.3390/life13101967 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Systematic Review
Fioranelli, Massimo
Roccia, Maria Grazia
Przybylek, Bianca
Garo, Maria Luisa
The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review
title The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review
title_full The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review
title_fullStr The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review
title_full_unstemmed The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review
title_short The Role of Brain-Derived Neurotrophic Factor (BDNF) in Depression and Cardiovascular Disease: A Systematic Review
title_sort role of brain-derived neurotrophic factor (bdnf) in depression and cardiovascular disease: a systematic review
topic Systematic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608007/
https://www.ncbi.nlm.nih.gov/pubmed/37895349
http://dx.doi.org/10.3390/life13101967
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