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Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities
Three new polyketides (penidihydrocitrinins A–C, 1–3) and fourteen known compounds (4–17) were isolated from the deep-sea-derived Penicillium citrinum W17. Their structures were elucidated by comprehensive analyses of 1D and 2D NMR, HRESIMS, and ECD calculations. Compounds 1–17 were evaluated for th...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608093/ https://www.ncbi.nlm.nih.gov/pubmed/37888473 http://dx.doi.org/10.3390/md21100538 |
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author | Zhang, Yong Xie, Chun-Lan Wang, Yuan He, Xi-Wen Xie, Ming-Min Li, You Zhang, Kai Zou, Zheng-Biao Yang, Long-He Xu, Ren Yang, Xian-Wen |
author_facet | Zhang, Yong Xie, Chun-Lan Wang, Yuan He, Xi-Wen Xie, Ming-Min Li, You Zhang, Kai Zou, Zheng-Biao Yang, Long-He Xu, Ren Yang, Xian-Wen |
author_sort | Zhang, Yong |
collection | PubMed |
description | Three new polyketides (penidihydrocitrinins A–C, 1–3) and fourteen known compounds (4–17) were isolated from the deep-sea-derived Penicillium citrinum W17. Their structures were elucidated by comprehensive analyses of 1D and 2D NMR, HRESIMS, and ECD calculations. Compounds 1–17 were evaluated for their anti-inflammatory and anti-osteoporotic bioactivities. All isolates exhibited significant inhibitory effects on LPS-stimulated nitric oxide production in murine brain microglial BV-2 cells in a dose-response manner. Notably, compound 14 displayed the strongest effect with the IC(50) value of 4.7 µM. Additionally, compounds 6, 7, and 8 significantly enhanced osteoblast mineralization, which was comparable to that of the positive control, purmorphamine. Furthermore, these three compounds also suppressed osteoclastogenesis in a dose-dependent manner under the concentrations of 2.5 μM, 5.0 μM, and 10 μM. |
format | Online Article Text |
id | pubmed-10608093 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-106080932023-10-28 Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities Zhang, Yong Xie, Chun-Lan Wang, Yuan He, Xi-Wen Xie, Ming-Min Li, You Zhang, Kai Zou, Zheng-Biao Yang, Long-He Xu, Ren Yang, Xian-Wen Mar Drugs Article Three new polyketides (penidihydrocitrinins A–C, 1–3) and fourteen known compounds (4–17) were isolated from the deep-sea-derived Penicillium citrinum W17. Their structures were elucidated by comprehensive analyses of 1D and 2D NMR, HRESIMS, and ECD calculations. Compounds 1–17 were evaluated for their anti-inflammatory and anti-osteoporotic bioactivities. All isolates exhibited significant inhibitory effects on LPS-stimulated nitric oxide production in murine brain microglial BV-2 cells in a dose-response manner. Notably, compound 14 displayed the strongest effect with the IC(50) value of 4.7 µM. Additionally, compounds 6, 7, and 8 significantly enhanced osteoblast mineralization, which was comparable to that of the positive control, purmorphamine. Furthermore, these three compounds also suppressed osteoclastogenesis in a dose-dependent manner under the concentrations of 2.5 μM, 5.0 μM, and 10 μM. MDPI 2023-10-14 /pmc/articles/PMC10608093/ /pubmed/37888473 http://dx.doi.org/10.3390/md21100538 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhang, Yong Xie, Chun-Lan Wang, Yuan He, Xi-Wen Xie, Ming-Min Li, You Zhang, Kai Zou, Zheng-Biao Yang, Long-He Xu, Ren Yang, Xian-Wen Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities |
title | Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities |
title_full | Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities |
title_fullStr | Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities |
title_full_unstemmed | Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities |
title_short | Penidihydrocitrinins A–C: New Polyketides from the Deep-Sea-Derived Penicillium citrinum W17 and Their Anti-Inflammatory and Anti-Osteoporotic Bioactivities |
title_sort | penidihydrocitrinins a–c: new polyketides from the deep-sea-derived penicillium citrinum w17 and their anti-inflammatory and anti-osteoporotic bioactivities |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608093/ https://www.ncbi.nlm.nih.gov/pubmed/37888473 http://dx.doi.org/10.3390/md21100538 |
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