Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells

Five new eudensamane-type sesquiterpene lactones, clasamanes A–E (1–5), three new dolabellane-type diterpenes, clabellanes A–C (6–8), and fifteen known compounds (9–23) were isolated from the ethanolic extract of Taiwanese soft coral Clavularia spp. The structures of all undescribed components (1–8)...

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Autores principales: Cheng, Ming-Ya, Chuang, Ya-Ting, Chang, Hsueh-Wei, Lin, Zheng-Yu, Chen, Ching-Yeu, Cheng, Yuan-Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608145/
https://www.ncbi.nlm.nih.gov/pubmed/37888464
http://dx.doi.org/10.3390/md21100529
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author Cheng, Ming-Ya
Chuang, Ya-Ting
Chang, Hsueh-Wei
Lin, Zheng-Yu
Chen, Ching-Yeu
Cheng, Yuan-Bin
author_facet Cheng, Ming-Ya
Chuang, Ya-Ting
Chang, Hsueh-Wei
Lin, Zheng-Yu
Chen, Ching-Yeu
Cheng, Yuan-Bin
author_sort Cheng, Ming-Ya
collection PubMed
description Five new eudensamane-type sesquiterpene lactones, clasamanes A–E (1–5), three new dolabellane-type diterpenes, clabellanes A–C (6–8), and fifteen known compounds (9–23) were isolated from the ethanolic extract of Taiwanese soft coral Clavularia spp. The structures of all undescribed components (1–8) were determined by analysis of IR, mass, NMR, and UV spectroscopic data. The absolute configuration of new compounds was determined by using circular dichroism and DP4+ calculations. The cytotoxic activities of all isolated marine natural products were evaluated. Compound 7 showed a significant cytotoxic effect against oral cancer cell line (Ca9-22) with an IC(50) value of 7.26 ± 0.17 μg/mL.
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spelling pubmed-106081452023-10-28 Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells Cheng, Ming-Ya Chuang, Ya-Ting Chang, Hsueh-Wei Lin, Zheng-Yu Chen, Ching-Yeu Cheng, Yuan-Bin Mar Drugs Article Five new eudensamane-type sesquiterpene lactones, clasamanes A–E (1–5), three new dolabellane-type diterpenes, clabellanes A–C (6–8), and fifteen known compounds (9–23) were isolated from the ethanolic extract of Taiwanese soft coral Clavularia spp. The structures of all undescribed components (1–8) were determined by analysis of IR, mass, NMR, and UV spectroscopic data. The absolute configuration of new compounds was determined by using circular dichroism and DP4+ calculations. The cytotoxic activities of all isolated marine natural products were evaluated. Compound 7 showed a significant cytotoxic effect against oral cancer cell line (Ca9-22) with an IC(50) value of 7.26 ± 0.17 μg/mL. MDPI 2023-10-08 /pmc/articles/PMC10608145/ /pubmed/37888464 http://dx.doi.org/10.3390/md21100529 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Ming-Ya
Chuang, Ya-Ting
Chang, Hsueh-Wei
Lin, Zheng-Yu
Chen, Ching-Yeu
Cheng, Yuan-Bin
Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells
title Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells
title_full Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells
title_fullStr Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells
title_full_unstemmed Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells
title_short Chemical Constituents from Soft Coral Clavularia spp. Demonstrate Antiproliferative Effects on Oral Cancer Cells
title_sort chemical constituents from soft coral clavularia spp. demonstrate antiproliferative effects on oral cancer cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10608145/
https://www.ncbi.nlm.nih.gov/pubmed/37888464
http://dx.doi.org/10.3390/md21100529
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